Prediction of Impending Rupture in Aneurysms Using 4D-CTA: Histopathological Verification of a Real-Time Minimally Invasive Tool in Unruptured Aneurysms

Kato, Yōkō; Hayakawa, Masayuki; Sano, Hirotoshi; Sunil, M; Imizu, Shuei; Yoneda, Minoru; Watanabe, Sadayoshi; Abe, Mitsunori; Kanno, Toru

doi:10.1055/s-2004-818492

Cited by 22 publications

(17 citation statements)

References 7 publications

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“…It is thought that the interaction between haemodynamics and wall mechanics plays a critical role in the formation, growth and rupture of aneurysms. The quantification of wall motion in aneurysms is becoming important since its likely connection with rupture [2,3,4] and its importance for incorporating patient-specific boundary conditions in CFD simulations [5].…”

Section: Introductionmentioning

confidence: 99%

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Wall motion estimation in intracranial aneurysms

et al. 2010

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Abstract. The quantification of wall motion in cerebral aneurysms is becoming important owing to its potential connection to rupture, and as a way to incorporate the effects of vascular compliance in computational fluid dynamics (CFD) simulations. Most of papers report values obtained with experimental phantoms, simulated images, or animal models, but the information for real patients is limited. In this paper, we have combined non-rigid registration (IR) with signal processing techniques to measure pulsation in real patients from high frame rate digital subtraction angiography (DSA). We have obtained physiological meaningful waveforms with amplitudes in the range 0mm-0.3mm for a population of 18 patients including ruptured and unruptured aneurysms. Statistically significant differences in pulsation were found according to the rupture status, in agreement with differences in biomechanical properties reported in the literature.

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Section: Introductionmentioning

confidence: 99%

“…We have applied the technique to quantify wall motion in 15 patients and found a correlation between rupture and regional differences in pulsation. [4] 4D-CTA in vivo All U 2/15 no Yaghmai et al [6] 4D-CTA phantom --yes Boecher-S. et al…”

Section: Introductionmentioning

confidence: 99%

Wall motion estimation in intracranial aneurysms

et al. 2010

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“…However, such techniques only consider static morphological information such as size and aspect ratio. On the other hand, it has been observed that aneurysms pulsate over the cardiac cycle [6]- [8] and rupture sites coincide with the areas of pulsation [9]- [11]. If such correlation exists, the availability of a robust morphodynamic analysis tool has the potential of impacting treatment selection and preoperative planning of cerebral aneurysms.…”

Section: Introductionmentioning

confidence: 99%

Morphodynamic Analysis of Cerebral Aneurysm Pulsation From Time-Resolved Rotational Angiography

Zhang

Villa‐Uriol²,

Craene³

et al. 2009

IEEE Trans. Med. Imaging

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Abstract-This paper presents a technique to estimate and model patient-specific pulsatility of cerebral aneurysms over one cardiac cycle, using 3D rotational X-ray angiography (3DRA) acquisitions. Aneurysm pulsation is modeled as a time varying -spline tensor field representing the deformation applied to a reference volume image, thus producing the instantaneous morphology at each time point in the cardiac cycle. The estimated deformation is obtained by matching multiple simulated projections of the deforming volume to their corresponding original projections. A weighting scheme is introduced to account for the relevance of each original projection for the selected time point. The wide coverage of the projections, together with the weighting scheme, ensures motion consistency in all directions. The technique has been tested on digital and physical phantoms that are realistic and clinically relevant in terms of geometry, pulsation and imaging conditions. Results from digital phantom experiments demonstrate that the proposed technique is able to recover subvoxel pulsation with an error lower than 10% of the maximum pulsation in most cases. The experiments with the physical phantom allowed demonstrating the feasibility of pulsation estimation as well as identifying different pulsation regions under clinical conditions. Index Terms-Image registration, motion analysis, three-dimensional rotational angiography, X-ray imaging.

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“…This means that at the moment there is no reliable means of predicting the rupture. Since observations during surgery shows that the aneurysms pulse ([4]-[8]), medical researchers are keen to study the relationship between the pulsatility and the rupture ( [9]- [11]). However, there is no existing reliable method to detect this motion.…”

Section: Introductionmentioning

confidence: 99%

A realistic Computed Tomography simulator for small motion analysis of cerebral aneurysms

Sepehri

Zouaoui

Thiran

2013

2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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Abstract² This paper describes a realistic simulator for the Computed Tomography (CT) scan process for motion analysis. In fact, we are currently developing a new framework to find small motion from the CT scan. In order to prove the fidelity of this framework, or potentially any other algorithm, we present in this paper a simulator to simulate the whole CT acquisition process with a priori known parameters. In other words, it is a digital phantom for the motion analysis that can be used to compare the results of any related algorithm with the groundtruth realistic analytical model. Such a simulator can be used by the community to test different algorithms in the biomedical imaging domain. The most important features of this simulator are its different considerations to simulate the best the real acquisition process and its generality.

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Prediction of Impending Rupture in Aneurysms Using 4D-CTA: Histopathological Verification of a Real-Time Minimally Invasive Tool in Unruptured Aneurysms

Cited by 22 publications

References 7 publications

Wall motion estimation in intracranial aneurysms

Wall motion estimation in intracranial aneurysms

Morphodynamic Analysis of Cerebral Aneurysm Pulsation From Time-Resolved Rotational Angiography

A realistic Computed Tomography simulator for small motion analysis of cerebral aneurysms

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