Prediction of in vitro fertilization rates from semen variables

Duncan, William W.; Glew, Mary J.; Wang, Xinjun; Flaherty, Sean P.; Matthews, Colin D.

doi:10.1016/s0015-0282(16)55982-2

Cited by 51 publications

(8 citation statements)

References 23 publications

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“…In particular, information on factors that may influence fertilization and pregnancy outcomes such as sperm morphology [19][20][21] and total progressive motile sperm count [22,23] was not available in this study. In addition, the sample size was limited by the small number of donor spermatozoa IVF cycles available for analysis.…”

Section: Discussionmentioning

confidence: 99%

Optimization of IVF pregnancy outcomes with donor spermatozoa

Wang

Douglas

Prosser

et al. 2009

J Assist Reprod Genet

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Purpose To identify risk factors for suboptimal IVF outcomes using insemination with donor spermatozoa and to define a lower threshold that may signal a conversion to fertilization by ICSI rather than insemination. Method Retrospective, age-matched, case-control study of women undergoing non-donor oocyte IVF cycles using either freshly ejaculated (N=138) or cryopreserved donor spermatozoa (N=69). Associations between method of fertilization, semen sample parameters, and pregnancy rates were analyzed. Results In vitro fertilization of oocytes with donor spermatozoa by insemination results in equivalent fertilization and pregnancy rates compared to those of freshly ejaculated spermatozoa from men with normal semen analyses when the post-processing motility is greater than or equal to 88%. IVF by insemination with donor spermatozoa when the post-processing motility is less than 88% is associated with a 5-fold reduction in pregnancy rates when compared to those of donor spermatozoa above this motility threshold. When the post-processing donor spermatozoa motility is low, fertilization by ICSI is associated with significantly higher pregnancy rates compared to those of insemination. Conclusion While ICSI does not need to be categorically instituted when using donor spermatozoa in IVF, patients should be counseled that conversion from insemination to ICSI may be recommended based on low post-processing motility.

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Section: Discussionmentioning

confidence: 99%

Optimization of IVF pregnancy outcomes with donor spermatozoa

Wang

Douglas

Prosser

et al. 2009

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…The role of traditional semen parameters (including sperm concentration, motility and morphology) as described in the World Health Organization (WHO, 1992) manual15 had only a limited predictive value as there is a lack of information on the sperm fertilization capacity for the in vivo situation 16…”

Section: Discussionmentioning

confidence: 99%

Correlation of Post Swim-Up Acrosome Index with in-vitro Fertilization Outcomes

2009

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PurposeA prospective study was planned to determine the relationship between post swim-up acrosome index (AI) evaluation and fertilization outcomes in an in vitro fertilization (IVF) program.Materials and MethodsInfertile couples who have applied to IVF were admitted into this study when the male partner's sperm concentration was > 20×106/mL and motility > 30%. Pre- and post swim-up semen quality parameters including concentration, motility, sperm morphology and AI were evaluated in a prospective, randomized and blinded fashion. The couples were divided prospectively into 2 groups. In group I (25 couples) 50 000 sperm per oocyte were used for insemination considering post swim-up acrosome index, and in group II (25 couples) 50 000 sperm per oocyte were used for insemination without considering post swim-up acrosome index.ResultsPre- and post swim-up AI were 30.8 ± 3.4 and 17.8 ± 4.5 in group I, and 31.4 ± 3.6 and 16.3 ± 4.7 in group II (p > 0.05) respectively. The significant improvement in morphology and motility after double wash swim-up procedure has been observed. However, double wash swim-up procedure could not eliminate head and especially acrosomal defects which would directly effect fertilization capacity in conventional IVF program. In group I, 85.3% of oocytes were fertilized, with a 48% pregnancy rate; in group II, 71.0% of oocytes were fertilized, with a pregnancy rate of 20%. Fertilization and pregnancy rates were significantly different (p < 0.05) between the two groups.ConclusionWe have concluded that it could be useful to consider post swim-up AI of sperm inseminated in conventional IVF cycles, which correlates with high fertilization and pregnancy rates.

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“…Although today many treatment units perform ICSI indifferently in all cases (Jain and Gupta 2007), the fertilization rates obtained with IVF have been shown to be similar to those observed after ICSI in couples with normal seminal parameters ( (Duncan et al 1993).…”

Section: In Vitro Fertilization (Ivf)mentioning

confidence: 90%