2003
DOI: 10.1001/archneur.60.10.1406
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Prediction of Incident Neurocognitive Impairment by Plasma HIV RNA and CD4 Levels Early After HIV Seroconversion

Abstract: Neurocognitive outcomes in HIV are strongly influenced by very early systemic virological and immunological events. Patients with high plasma levels of HIV RNA and low CD4 counts early after infection should be aggressively treated to prevent immunological decline and NP deterioration.

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Cited by 68 publications
(46 citation statements)
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“…Within 5 years of estimated seroconversion, approximately 10% of those patients whose study baseline CD4 þ cell counts were greater than 400 cells/ml had developed HIV-related neurocognitive impairment. Conversely, 40% of those patients whose CD4 þ cell counts were less than 400 cells/ml at study baseline became neurocognitively impaired over the same time period [46]. Plasma viral loads greater than 30 000 copies/ml also independently predicted more rapid neurocognitive decline.…”
Section: Early Hiv Infection Of the Brainmentioning
confidence: 97%
See 1 more Smart Citation
“…Within 5 years of estimated seroconversion, approximately 10% of those patients whose study baseline CD4 þ cell counts were greater than 400 cells/ml had developed HIV-related neurocognitive impairment. Conversely, 40% of those patients whose CD4 þ cell counts were less than 400 cells/ml at study baseline became neurocognitively impaired over the same time period [46]. Plasma viral loads greater than 30 000 copies/ml also independently predicted more rapid neurocognitive decline.…”
Section: Early Hiv Infection Of the Brainmentioning
confidence: 97%
“…Predictors of clinical neurocognitive disease progression in early HIV disease have been described in one longitudinal study from the pre-HAART era of 76 patients who seroconverted a median of 11 months (range, 1 month-4 years) prior to study entry [46]. Within 5 years of estimated seroconversion, approximately 10% of those patients whose study baseline CD4 þ cell counts were greater than 400 cells/ml had developed HIV-related neurocognitive impairment.…”
Section: Early Hiv Infection Of the Brainmentioning
confidence: 99%
“…In general, higher CD4 cell counts, lower CD8 cell counts, and higher CD4:CD8 ratios have been associated with better neurobehavioral functioning [16]. However, contradictory data for adults [17] and children [18] have been presented.…”
Section: H I V / a I D S M A J O R A R T I C L Ementioning
confidence: 99%
“…HIV patients perform poorly on measures of complex attention, information processing speed and verbal memory, mental flexibility, motor speed, and verbal fluency [31][32][33][34][35][36][37][38]. This profile is typical of a "subcortical pattern" of brain injury [39] and is consistent with evidence of white matter and basal ganglia involvement found in neuropathologic studies.…”
Section: The Impact Of Hiv Monoinfection On Neuropsychological Outcomementioning
confidence: 58%