Prediction of paroxysmal atrial fibrillation using new heart rate variability features

Parsi, Ashkan; Glavin, Martin; Jones, Edward; Byrne, Dallan

doi:10.1016/j.compbiomed.2021.104367

Cited by 45 publications

(23 citation statements)

References 58 publications

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“…The importance of feature selection increases with the number of requirements for the classification performance of a model. In [ 44 , 45 ], both studies extracted HRV relative features as the model input, and showed an excellent performance. However, the number of subjects in their training set and test set was insufficient.…”

Section: Discussionmentioning

confidence: 99%

A Classification and Prediction Hybrid Model Construction with the IQPSO-SVM Algorithm for Atrial Fibrillation Arrhythmia

Wang

Yan

Yang

et al. 2021

Sensors

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Atrial fibrillation (AF) is the most common cardiovascular disease (CVD), and most existing algorithms are usually designed for the diagnosis (i.e., feature classification) or prediction of AF. Artificial intelligence (AI) algorithms integrate the diagnosis of AF electrocardiogram (ECG) and predict the possibility that AF will occur in the future. In this paper, we utilized the MIT-BIH AF Database (AFDB), which is composed of data from normal people and patients with AF and onset characteristics, and the AFPDB database (i.e., PAF Prediction Challenge Database), which consists of data from patients with Paroxysmal AF (PAF; the records contain the ECG preceding an episode of PAF), and subjects who do not have documented AF. We extracted the respective characteristics of the databases and used them in modeling diagnosis and prediction. In the aspect of model construction, we regarded diagnosis and prediction as two classification problems, adopted the traditional support vector machine (SVM) algorithm, and combined them. The improved quantum particle swarm optimization support vector machine (IQPSO-SVM) algorithm was used to speed the training time. During the verification process, the clinical FZU-FPH database created by Fuzhou University and Fujian Provincial Hospital was used for hybrid model testing. The data were obtained from the Holter monitor of the hospital and encrypted. We proposed an algorithm for transforming the PDF ECG waveform images of hospital examination reports into digital data. For the diagnosis model and prediction model trained using the training set of the AFDB and AFPDB databases, the sensitivity, specificity, and accuracy measures were 99.2% and 99.2%, 99.2% and 93.3%, and 91.7% and 92.5% for the test set of the AFDB and AFPDB databases, respectively. Moreover, the sensitivity, specificity, and accuracy were 94.2%, 79.7%, and 87.0%, respectively, when tested using the FZU-FPH database with 138 samples of the ECG composed of two labels. The composite classification and prediction model using a new water-fall ensemble method had a total accuracy of approximately 91% for the test set of the FZU-FPH database with 80 samples with 120 segments of ECG with three labels.

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Section: Discussionmentioning

confidence: 99%

A Classification and Prediction Hybrid Model Construction with the IQPSO-SVM Algorithm for Atrial Fibrillation Arrhythmia

Wang

Yan

Yang

et al. 2021

Sensors

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“…The most challenging recent application using HRV features is atrial fibrillation (AFIB) detection (e.g., Smisek et al, 2018 ; Murat et al, 2021a ). Timely prediction of paroxysmal AFIB episodes using seven novel Poincaré map features achieves the accuracy over 86% for different ML models and even higher accuracy (98%) when combining with standard HRV features ( Parsi et al, 2021b ). McCann et al (2021) studied ECG records from patients undergoing catheter ablation.…”

Section: Ecg Analysismentioning

confidence: 98%

Golden Standard or Obsolete Method? Review of ECG Applications in Clinical and Experimental Context

et al. 2022

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Cardiovascular system and its functions under both physiological and pathophysiological conditions have been studied for centuries. One of the most important steps in the cardiovascular research was the possibility to record cardiac electrical activity. Since then, numerous modifications and improvements have been introduced; however, an electrocardiogram still represents a golden standard in this field. This paper overviews possibilities of ECG recordings in research and clinical practice, deals with advantages and disadvantages of various approaches, and summarizes possibilities of advanced data analysis. Special emphasis is given to state-of-the-art deep learning techniques intensely expanded in a wide range of clinical applications and offering promising prospects in experimental branches. Since, according to the World Health Organization, cardiovascular diseases are the main cause of death worldwide, studying electrical activity of the heart is still of high importance for both experimental and clinical cardiology.

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“…In this work, we chose the discretized Poincaré plot to perform such a conversion for its easy construction, modification, and interpretation. In addition, it has been related to HRV physiology [38,39] and adopted for HRV analysis on PAF prediction for decades [11,13,[40][41][42]. However, most of the previous works used features that measure only a certain facet of the plot and thus the information carried in the plot is not fully utilized.…”

Section: Feature Matrices Conversionmentioning

confidence: 99%

A Heart Rate Variability-Based Paroxysmal Atrial Fibrillation Prediction System

et al. 2022

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Atrial fibrillation (AF) is characterized by totally disorganized atrial depolarizations without effective atrial contraction. It is the most common form of cardiac arrhythmia, affecting more than 46.3 million people worldwide and its incidence rate remains increasing. Although AF itself is not life-threatening, its complications, such as strokes and heart failure, are lethal. About 25% of paroxysmal AF (PAF) patients become chronic for an observation period of more than one year. For long-term and real-time monitoring, a PAF prediction system was developed with four objectives: (1) high prediction accuracy, (2) fast computation, (3) small data storage, and (4) easy medical interpretations. The system takes a 400-point heart rate variability (HRV) sequence containing no AF episodes as the input and outputs whether the corresponding subject will experience AF episodes in the near future (i.e., 30 min). It first converts an input HRV sequence into four image matrices via extended Poincaré plots to capture inter- and intra-person features. Then, the system employs a convolutional neural network (CNN) to perform feature selection and classification based on the input image matrices. Some design issues of the system, including feature conversion and classifier structure, were formulated as a binary optimization problem, which was then solved via a genetic algorithm (GA). A numerical study involving 6085 400-point HRV sequences excerpted from three PhysioNet databases showed that the developed PAF prediction system achieved 87.9% and 87.2% accuracy on the validation and the testing datasets, respectively. The performance is competitive with that of the leading PAF prediction system in the literature, yet our system is much faster and more intensively tested. Furthermore, from the designed inter-person features, we found that PAF patients often possess lower (~60 beats/min) or higher (~100 beats/min) heart rates than non-PAF subjects. On the other hand, from the intra-person features, we observed that PAF patients often exhibit smaller variations (≤5 beats/min) in heart rate than non-PAF subjects, but they may experience short bursts of large heart rate changes sometimes, probably due to abnormal beats, such as premature atrial beats. The other findings warrant further investigations for their medical implications about the onset of PAF.

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Prediction of paroxysmal atrial fibrillation using new heart rate variability features

Cited by 45 publications

References 58 publications

A Classification and Prediction Hybrid Model Construction with the IQPSO-SVM Algorithm for Atrial Fibrillation Arrhythmia

A Classification and Prediction Hybrid Model Construction with the IQPSO-SVM Algorithm for Atrial Fibrillation Arrhythmia

Golden Standard or Obsolete Method? Review of ECG Applications in Clinical and Experimental Context

A Heart Rate Variability-Based Paroxysmal Atrial Fibrillation Prediction System

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