Prediction of Postoperative Ileus in Patients With Colorectal Cancer by Preoperative Gut Microbiota

Geng, Rui; Liu, Yang; Liu, Lujia; Jin, Xiangren; Zhao, Fuya; Feng, Jing; Wei, Yunwei

doi:10.3389/fonc.2020.526009

Cited by 19 publications

(18 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, very few clinical studies have linked gut microbiota with SSI or POI-related bacteria in CRC patients after surgery. Only one recent clinical study reported Faecalibacterium in mucosal samples from CRC patients as a possible predictive biomarker of POI [ 98 ]. Ohigashi et al is the only clinical report to identify causative fecal bacteria enriched in SSI after CRC surgery: S. aureus , P. aeruginosa , and Enterococcus spp.…”

Section: Gut Microbiota Biomarkers Predicting Prognosis And/or Treatment Responsementioning

confidence: 99%

Gut Microbiota as Potential Biomarker and/or Therapeutic Target to Improve the Management of Cancer: Focus on Colibactin-Producing Escherichia coli in Colorectal Cancer

Véziant

Villéger

Barnich

et al. 2021

Cancers

View full text Add to dashboard Cite

The gut microbiota is crucial for physiological development and immunological homeostasis. Alterations of this microbial community called dysbiosis, have been associated with cancers such colorectal cancers (CRC). The pro-carcinogenic potential of this dysbiotic microbiota has been demonstrated in the colon. Recently the role of the microbiota in the efficacy of anti-tumor therapeutic strategies has been described in digestive cancers and in other cancers (e.g., melanoma and sarcoma). Different bacterial species seem to be implicated in these mechanisms: F. nucleatum, B. fragilis, and colibactin-associated E. coli (CoPEC). CoPEC bacteria are prevalent in the colonic mucosa of patients with CRC and they promote colorectal carcinogenesis in susceptible mouse models of CRC. In this review, we report preclinical and clinical data that suggest that CoPEC could be a new factor predictive of poor outcomes that could be used to improve cancer management. Moreover, we describe the possibility of using these bacteria as new therapeutic targets.

show abstract

Section: Gut Microbiota Biomarkers Predicting Prognosis And/or Treatment Responsementioning

confidence: 99%

Gut Microbiota as Potential Biomarker and/or Therapeutic Target to Improve the Management of Cancer: Focus on Colibactin-Producing Escherichia coli in Colorectal Cancer

Véziant

Villéger

Barnich

et al. 2021

Cancers

View full text Add to dashboard Cite

show abstract

“…Despite standard administration of perioperative antibiotics, significant changes of gut microbiota can be observed in surgical patients: bowel obstruction, for example due to colorectal carcinoma, is associated with a change of gut microbiota composition [43,44]. The aforementioned study by Hegde et al observed that the diversity measured by Shannon Index was higher in rats with bowel obstruction than in rats without.…”

Section: Research Question 1: Changes Of Gut Microbiota In Surgical Patientsmentioning

confidence: 99%

“…Another trial by Jin et al reported the results of a prospective cohort study evaluating the gut microbiota of colorectal cancer patients with pre-or post-operative ileus compared to patients with no ileus [44]. They found significant differences of diversity measured by Shannon Index and UniFrac in patients with and without ileus.…”

Section: Research Question 1: Changes Of Gut Microbiota In Surgical Patientsmentioning

confidence: 99%

“…Patients with ileus had lower levels of Firmicutes (43% vs. 57%), Bacteroidetes (23% vs. 77%), and Fusobacteria (20% vs. 80%), but higher levels of Proteobacteria (71% vs. 29%) and Actinobacteria (61% vs. 39%) compared to patients without ileus. The risk of postoperative ileus was significantly increased when Faecalibacterium was depleted preoperatively [44]. The results of the trial by Jin et al are interesting naming a potentially predictive microbial species for prevention of postoperative ileus, but the study validity is limited due to missing data about antibiotic treatment of included patients.…”

Section: Research Question 1: Changes Of Gut Microbiota In Surgical Patientsmentioning

confidence: 99%

See 1 more Smart Citation

Current Insights: The Impact of Gut Microbiota on Postoperative Complications in Visceral Surgery—A Narrative Review

et al. 2021

View full text Add to dashboard Cite

Postoperative complications are a major problem occurring in up to 50% of patients undergoing major abdominal surgery. Occurrence of postoperative complications is associated with a significantly higher morbidity and mortality in affected patients. The most common postoperative complications are caused by an infectious genesis and include anastomotic leakage in case of gastrointestinal anastomosis and surgical site infections. Recent research highlighted the importance of gut microbiota in health and disease. It is plausible that the gut microbiota also plays a pivotal role in the development of postoperative complications. This narrative review critically summarizes results of recent research in this particular field. The review evaluates the role of gut microbiota alteration in postoperative complications, including postoperative ileus, anastomotic leakage, and surgical site infections in visceral surgery. We tried to put a special focus on a potential diagnostic value of pre- and post-operative gut microbiota sampling showing that recent data are inhomogeneous to identify a high-risk microbial profile for development of postoperative complications.

show abstract

“…Similar to existing studies [24][25][26][27][28] , 16S rRNA gene (V3-V4 region) sequencing was used to investigate the microbiota content, although it may not be possible to achieve specieslevel differentiation. We formalized the task of CRC or adenoma prediction as a classification problem and focused on operational classification units (OTUs).…”

Section: /31mentioning

confidence: 99%

Accurate Five-category Classification for Colorectal Cancer Using Gut Microbiome 16S rRNA Sequencing

Zhang¹,

Zhu²,

Ding³

et al. 2021

Preprint

View full text Add to dashboard Cite

The association between the gut microbiome and the five stages of colorectal cancer (CRC) (healthy, polyposis, nonadvanced adenoma, advanced adenoma, and cancer) remains unclear. We performed 16S rRNA sequencing of the V3-V4 amplicon from 999 samples from subjects at various stages of CRC development and constructed an accurate predictive random forest model for CRC development. In the testing set, our five-category CRC prediction classifier had accuracies of 0.84 and 0.74 using the relative operational taxonomic unit (OTU) abundances and relative genus abundances, respectively. Specifically, the OTU-based classifier had a sensitivity of 0.97 and specificity of 0.97 for CRC samples, and the genus-based classifier had a sensitivity of 0.97 and specificity of 0.95 for CRC samples. Meanwhile, the gut microbiota was found to differ at all stages of CRC development. The differential abundances of closely related bacteria were used to accurately classify the five stages of CRC development. Additionally, both unannotated and annotated OTUs played important roles in classifier modelling. Our work not only provides valuable 16S rRNA sequencing data from patients and healthy individuals on a large scale but also identifies reproducible gut microbiome biomarkers for CRC staging and highlights their potential applications as noninvasive microbiome biomarkers for diagnosis and as predictive CRC screening tests.

show abstract

Prediction of Postoperative Ileus in Patients With Colorectal Cancer by Preoperative Gut Microbiota

Cited by 19 publications

References 49 publications

Gut Microbiota as Potential Biomarker and/or Therapeutic Target to Improve the Management of Cancer: Focus on Colibactin-Producing Escherichia coli in Colorectal Cancer

Gut Microbiota as Potential Biomarker and/or Therapeutic Target to Improve the Management of Cancer: Focus on Colibactin-Producing Escherichia coli in Colorectal Cancer

Current Insights: The Impact of Gut Microbiota on Postoperative Complications in Visceral Surgery—A Narrative Review

Accurate Five-category Classification for Colorectal Cancer Using Gut Microbiome 16S rRNA Sequencing

Contact Info

Product

Resources

About