Prediction of Residual Disease or Distant Metastasis After Resection of Locally Recurrent Rectal Cancer

Abstract

It was possible to preoperatively identify patients at high risk of relapse or residual disease. This system might be used on an individual basis to select patients with locally recurrent rectal cancer for chemotherapy or radiotherapy before surgical intervention with curative intent.

Meta‐analysis of survival based on resection margin status following surgery for recurrent rectal cancer

“…Sacrectomy was described in 16% (213 ⁄ 1307) of cases. From nine centres which offered intra-operative radiotherapy, 55% of patients received it with a range in individual studies of 8-100% [7,8,[14][15][16][17][18][19][20].…”

“…Median blood loss, described by three studies [7,17,19], was 2500 ml with a range of 0-34 000 ml. Median operating time was 375 min with a range of 32-1101 min [7,17,19].…”

“…Median blood loss, described by three studies [7,17,19], was 2500 ml with a range of 0-34 000 ml. Median operating time was 375 min with a range of 32-1101 min [7,17,19]. The overall 30-day mortality following surgery, as reported in 10 studies, was 4% (26 ⁄ 670) with a range of 0-16% for individual studies [7,15,16,18,19,[21][22][23][24][25].…”

“…The overall 30-day mortality following surgery, as reported in 10 studies, was 4% (26 ⁄ 670) with a range of 0-16% for individual studies [7,15,16,18,19,[21][22][23][24][25]. The median length of stay from four studies was 14.5 days (range 4-466 days) [16][17][18][19]. The major complication rate was 51% (370 ⁄ 729), with a rate varying from 27 to 81% from individual studies [7,[15][16][17]19,21,[23][24][25].…”

“…The median length of stay from four studies was 14.5 days (range 4-466 days) [16][17][18][19]. The major complication rate was 51% (370 ⁄ 729), with a rate varying from 27 to 81% from individual studies [7,[15][16][17]19,21,[23][24][25]. There were insufficient data to meta-analyse the differences in these variables between resection margin status.…”