Prediction of short-term prognosis in elderly patients with spontaneous intracerebral hemorrhage

Batista, Antônio M.; Osório, Rui; Varela, Ana Verónica; Guilherme, Patrı́cia; Marreiros, Ana; Pais, Sandra; Nzwalo, Hipólito

doi:10.1007/s41999-021-00529-w

Cited by 8 publications

(6 citation statements)

References 21 publications

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“…On admission, the enrolled patients had moderate and severe symptoms based on the NIHSS score and mRS, respectively, which alone might indicate a poor prognosis. High hospital (39.1%) and 3 month mortality figures (46.5%) have been similar to those in recently published studies ( 4 , 5 ).…”

Section: Discussionsupporting

confidence: 91%

“…On admission, most of our patients were severely disabled (mRS 5), but by day 14 and over 3 months, their disabilities improved, although mortality was high, but the independent favorable (mRS 0-2) patients' number increased within the survivor group. The mortality rate was different in the different examinations, but mostly similar to our findings (3)(4)(5)37).…”

Section: Neurophysiological Examinations and Outcomesupporting

confidence: 90%

“…Therefore, methods that may predict the outcome play an important role in daily clinical routine. Most studies in this field investigate clinical and radiographic predictors of ICH outcome, for example, age, premorbid functional state, initial GCS score, blood pressure, hematoma location, and volume ( 3 , 4 , 19 , 28 – 30 ). So far, many factors are known, but little has been published about the importance of neurophysiological examinations such as EEG and evoked potentials, which give information about function and prognosis, and at which time point it is most relevant.…”

Section: Discussionmentioning

confidence: 99%

“…Although non-Traumatic intracerebral hemorrhage (ICH) affects 1 in 10 patients, case fatality and severe disability are very high among them (1)(2)(3). The incidence and the 30-day mortality of ICH are high (∼40%), in elderly patients (4,5). In addition, hemorrhage in the brain stem, intraventricular dissection, hematoma volume ≥30 cm 3 and Glasgow Coma Scale (GCS) score < 5 are also poor prognostic factors (5,6).…”

Section: Introductionmentioning

confidence: 99%

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Neurophysiological Examinations as Adjunctive Tool to Imaging Techniques in Spontaneous Intracerebral Hemorrhage: IRONHEART Study

et al. 2021

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Introduction: Intracerebral hemorrhage (ICH) is a devastating disease, which may lead to severe disability or even death. Although many factors may influence the outcome, neurophysiological examinations might also play a role in its course. Our aim was to examine whether the findings of electroencephalography (EEG) and transcranial magnetic stimulation (TMS) can predict the prognosis of these patients.Methods: Between June 1 2017 and June 15 2021, 116 consecutive patients with ICH were enrolled prospectively in our observational study. Clinical examinations and non-Contrast computed tomography (NCCT) scan were done on admission for ICH; follow-up NCCT scans were taken at 14 ± 2 days and at 3 months ± 7 days after stroke onset. EEG and TMS examinations were also carried out.Results: Of the patients in the study, 65.5% were male, and the mean age of the study population was 70 years. Most patients had a history of hypertension, 50.8% of whom had been untreated. In almost 20% of the cases, excessive hypertension was measured on admission, accompanied with >10 mmol/L blood glucose level, whereas their Glasgow Coma Scale was 12 on average. Presence of blood in the ventricles or subarachnoid space and high blood and perihematomal volumes meant poor prognosis. Pathological EEG was prognostic of a worse outcome. With TMS examination at 14 days, it might be possible to estimate outcome in a univariate model and the absence, or reduction of the amplitude of the motor evoked potentials was associated with poor prognosis.Conclusion: Together with the clinical symptoms, the volume of bleeding, perihematomal edema (or their combined volume), and neurophysiological examinations like EEG and TMS play an important role in the neurological outcome of patients with ICH. This might affect the patients' rehabilitation plans in the future, since with the help of the examinations the subset of patients with potential for recovery could be identified.

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Section: Discussionsupporting

confidence: 91%

Section: Neurophysiological Examinations and Outcomesupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neurophysiological Examinations as Adjunctive Tool to Imaging Techniques in Spontaneous Intracerebral Hemorrhage: IRONHEART Study

et al. 2021

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“…To this end, brain herniation in the young group, and low GCS scores, renal or heart disease, and leukocytosis in the elderly were associated with higher 1-month mortality ( Yang et al, 2020 ). Also, studies on elderly patients with age ≥75 years demonstrated that a hematoma volume ≥30 ml, or a prior history of ICH was associated with a higher likelihood of short-term death ( Batista et al, 2021 ). Apart from these, blood-derived inflammation markers could serve as prognostic indicators.…”

Section: Introductionmentioning

confidence: 99%

Intracerebral Hemorrhage: The Effects of Aging on Brain Injury

Watson

Bonsack

Sukumari‐Ramesh

2022

Front. Aging Neurosci.

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Intracerebral hemorrhage (ICH) is a devastating subtype of stroke with high rates of mortality and morbidity. ICH patients often suffer devastating and debilitating neurological impairments, from which the majority of victims are unable to fully recover to functional independence. Unfortunately, there is no established medical therapy for ICH, which is partly attributed to the lack of understanding of the complex pathology of the disorder. Despite advanced age being a major risk factor of ICH, most preclinical studies on ICH employed young animal subjects. Due to this discrepancy, the molecular level changes in the aging brain after ICH are largely unknown, limiting the translation of preclinical studies into potential human treatments. The purpose of this review is to highlight the effects of advanced age on ICH- induced brain injury and recovery and to draw attention to current knowledge gaps, which warrant further investigation.

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Risk factors for unfavorable outcome after spontaneous intracerebral hemorrhage in elderly patients

Zeiser,

Khalaveh,

Cho

et al. 2024

Clinical Neurology and Neurosurgery

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Prediction of short-term prognosis in elderly patients with spontaneous intracerebral hemorrhage

Cited by 8 publications

References 21 publications

Neurophysiological Examinations as Adjunctive Tool to Imaging Techniques in Spontaneous Intracerebral Hemorrhage: IRONHEART Study

Neurophysiological Examinations as Adjunctive Tool to Imaging Techniques in Spontaneous Intracerebral Hemorrhage: IRONHEART Study

Intracerebral Hemorrhage: The Effects of Aging on Brain Injury

Risk factors for unfavorable outcome after spontaneous intracerebral hemorrhage in elderly patients

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