Prediction of the course of diverticular disease in its combination with adenomatous polyps and colorectal cancer in the context of clinical and instrumental data  and expression of Ki-67 and α-SMA in the intestinal mucosa

Осадчук, М А; Svistunov, Andrey; Zolotovitskaya, Alexandra; Решетников, В. А.; Kozlov, Vasiliy; Mironova, Ekaterina D.; Ogibenina, Ekaterina Sergeevna

doi:10.14300/mnnc.2019.14152

Medical news of the North Caucasus

2019

DOI: 10.14300/mnnc.2019.14152

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Prediction of the course of diverticular disease in its combination with adenomatous polyps and colorectal cancer in the context of clinical and instrumental data and expression of Ki-67 and α-SMA in the intestinal mucosa

М А Осадчук¹,

Andrey Svistunov²,

Alexandra Zolotovitskaya³

et al.

Abstract: изучена роль клинико-инструментальных данных, экспрессии Ki-67 и α-гладкомышечного актина (α-SMA) в слизистой оболочке толстого кишечника у больных с дивертикулярной болезнью толстого кишечника (ДБтК) и при ее сочетании с аденоматозными полипами кишечника (аПК) и колоректальным раком (Крр). В исследование были включены 190 больных с ДБтК (120 человек; 1-я группа), при ее сочетании с аПК (55 пациентов; 2-я группа) и с Крр (15 больных; 3-я группа). Контрольная группа была представлена 28 пациентами с синдромом р… Show more

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2024

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Expression of motilin and vasoactive intestinal peptide in diverticular disease of the colon

Osadchuk,

Mironova,

Krylova

et al. 2024

Terapevticheskii arkhiv

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Aim. To determine the role of the expression of motilin and vasoactive intestinal peptide (VIP) in diverticular disease of the large intestine (DD). Materials and methods. Examined 45 patients with DD. The comparison group consisted of 30 practically healthy people. Patients and healthy people were examined according to a single program, including clinical, instrumental (colonoscopy and ultrasound examination of the abdominal cavity and), laboratory (blood glucose, cholesterol, alanine aminotransferase and aspartate aminotransferase) and immunomorphological research methods – use of primary antibodies to motilin (PA5-76926, Invitrogen, USA) and VIP (Ab22736, 1:800, Abcam, UK). Results. For DD, clinical symptoms are characteristic, mainly fit into the manifestations of functional disorders (constipation, pain along the colon, bloating and increased gas formation). In patients with DD, an increase in body mass index, cholesterol and glucose levels was found. In this category of patients, examinations often verify diabetes mellitus (40%), arterial hypertension (64.4%), cholelithiasis (44.4%), non-alcoholic fatty liver disease (55.5%), gastroesophageal reflux disease (60%). In the group of patients with DD, a significant decrease in the expression of VIP and motilin in the mucous membrane of the large intestine was recorded compared with the group of healthy people (17.31 vs 34.67; p0.05 and 64.42 vs 76.50; p0.05 respectively). Conclusion. The obtained results give grounds to conclude that a decrease in the expression of VIP and motilin in the mucosa of the sigmoid colon is accompanied by hypotension of the colon, which directly and indirectly leads to a violation of the regeneration of the mucosa, which leads to the manifestation of DD.

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Expression of motilin and vasoactive intestinal peptide in diverticular disease of the colon

Osadchuk,

Mironova,

Krylova

et al. 2024

Terapevticheskii arkhiv

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show abstract

Clinical, endoscopic, laboratory and immunomorphological parameters in predicting the occurrence of colorectal cancer in patients with diverticular disease of the colon

Svistunov,

Osadchuk,

Mironova

et al. 2024

Terapevticheskii arkhiv

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Aim. To define the role of clinical, endoscopic, laboratory and immunomorphological parameters in predicting the occurrence and course of colorectal cancer (CRC) in patients with diverticular disease of the colon (DDC). Materials and methods. One hundred and seventy five people with DDC were examined, divided into 3 groups: group 1 – 85 patients with DDC; group 2 – 45 with DDC in combination with adenomatous polyps (AP); 3rd group – 45 with DDC with established CRC (I or II stage). The control group consisted of 30 practically healthy people. Patients and healthy people were examined according to a single program: clinical, laboratory, instrumental data and immunomorphological research methods [use of primary antibodies to p53 (mAb clone DO-7 product no. PA0057, Leica Biosystems, Leica Bond III) and Ki-67 (Ab16667, Abcam, UK)]. Results. Among the main complaints in patients with DDC and CRC, constipation was more common than in patients with DDC and DDC with AP (p0.05). In patients with DDC and colorectal neoplasia, a positive reaction to occult blood in the feces was more often verified, compared with the group with DDC (p0.05). Higher levels of glucose and cholesterol in blood plasma, as well as body mass index were found in patients with DDC with AP and CRC, compared with the DDC group (p0.05). A higher level of expression of Ki-67 and p53 was found in patients with DDC combined with AP and CRC, compared with patients with DDC without colorectal neoplasia (p0.05). At the same time, in patients with DDC with CRC, the expression level of Ki-67 and p53 was higher than in patients with DDC with AP (p0.05) Conclusion. In patients with DDC combined with AP and CRC, higher levels of glucose, plasma cholesterol, as well as body mass index were observed compared to the group of patients with DDC alone (p0.05). Of note, the results of the determination of Ki-67 and p53 in the mucous membrane of the colon should be considered important prognostic markers for the development of CRC in patients with DDC.

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Prediction of the course of diverticular disease in its combination with adenomatous polyps and colorectal cancer in the context of clinical and instrumental data and expression of Ki-67 and α-SMA in the intestinal mucosa

Cited by 2 publications

References 10 publications

Expression of motilin and vasoactive intestinal peptide in diverticular disease of the colon

Expression of motilin and vasoactive intestinal peptide in diverticular disease of the colon

Clinical, endoscopic, laboratory and immunomorphological parameters in predicting the occurrence of colorectal cancer in patients with diverticular disease of the colon

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