Prediction of the Inelastic Behaviour of Radius Segments: Damage-based Nonlinear Micro Finite Element Simulation vs Pistoia Criterion

Stipsitz, Monika; Zysset, Philippe; Pahr, Dieter H.

doi:10.1016/j.jbiomech.2020.110205

Cited by 8 publications

(1 citation statement)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, nonlinear models could be implemented to account for local damage and localization of deformation in tibia from OVX and treated bones. Nonlinear microFE models have been recently applied to the human radius from lower resolution images 65 and future applications in preclinical studies to evaluate the bone strength in the mouse tibia could be explored, after proper validation versus experiments and improvement of microFE model efficiency.…”

Section: Discussionmentioning

confidence: 99%

Combining PTH(1‐34) and mechanical loading has increased benefit to tibia bone mechanics in ovariectomised mice

Roberts,

Cheong,

Oliviero

et al. 2024

Journal Orthopaedic Research

View full text Add to dashboard Cite

Combined treatment with PTH(1‐34) and mechanical loading confers increased structural benefits to bone than monotherapies. However, it remains unclear how this longitudinal adaptation affects the bone mechanics. This study quantified the individual and combined longitudinal effects of PTH(1‐34) and mechanical loading on the bone stiffness and strengthe evaluated in vivo with validated micro‐finite element (microFE) models. C57BL/6 mice were ovariectomised at 14‐weeks‐old and treated either with injections of PTH(1‐34), compressive tibia loading or both interventions concurrently. Right tibiae were in vivo microCT‐scanned every two weeks from 14 until 24‐weeks‐old. MicroCT images were rigidly registered to reference tibia and the cortical organ (whole bone) and tissue‐level (midshaft) morphometric properties and bone mineral content were quantified. MicroCT images were converted into voxel‐based homogeneous, linear elastic microFE models to estimate the bone stiffness and strength. This approach allowed us for the first time to quantify the longitudinal changes in mechanical properties induced by combined treatments in a model of accelerated bone resorption. Both changes of stiffness and strength were higher with co‐treatment than with individual therapies, consistent with increased benefits with the tibia bone mineral content and cortical area – properties strongly associated with the tibia mechanics. The longitudinal data shows thatthe two bone anabolics, both individually and combined, had persistent benefit on estimated mechanical properties, and that benefits (increased stiffness and strength) remained after treatment was withdrawn.This article is protected by copyright. All rights reserved.

show abstract

Section: Discussionmentioning

confidence: 99%

Combining PTH(1‐34) and mechanical loading has increased benefit to tibia bone mechanics in ovariectomised mice

Roberts,

Cheong,

Oliviero

et al. 2024

Journal Orthopaedic Research

View full text Add to dashboard Cite

show abstract

A Density-Dependent Target Stimulus for Inverse Bone (Re)modeling with Homogenized Finite Element Models

2022

Self Cite

View full text Add to dashboard Cite

Inverse bone (re)modeling (IBR) can infer physiological loading conditions from the bone microstructure. IBR scales unit loads, imposed on finite element (FE) models of a bone, such that the trabecular microstructure is homogeneously loaded and the difference to a target stimulus is minimized. Micro-FE (µFE) analyses are typically used to model the microstructure, but computationally more efficient, homogenized FE (hFE) models, where the microstructure is replaced by an equivalent continuum, could be used instead. However, also the target stimulus has to be translated from the tissue to the continuum level. In this study, a new continuum-level target stimulus relating relative bone density and strain energy density is proposed. It was applied using different types of hFE models to predict the physiological loading of 21 distal radii sections, which was subsequently compared to µFE-based IBR. The hFE models were able to correctly identify the dominant load direction and showed a high correlation of the predicted forces, but mean magnitude errors ranged from − 14.7 to 26.6% even for the best models. While µFE-based IBR can still be regarded as a gold standard, hFE-based IBR enables faster predictions, the usage of more sophisticated boundary conditions, and the usage of clinical images.

show abstract

HR-pQCT parameters of the distal radius correlate with the bending strength of the radial diaphysis

Uppuganti

Ketsiri

Zhang

et al. 2022

Bone

View full text Add to dashboard Cite

Prediction of the Inelastic Behaviour of Radius Segments: Damage-based Nonlinear Micro Finite Element Simulation vs Pistoia Criterion

Cited by 8 publications

References 24 publications

Combining PTH(1‐34) and mechanical loading has increased benefit to tibia bone mechanics in ovariectomised mice

Combining PTH(1‐34) and mechanical loading has increased benefit to tibia bone mechanics in ovariectomised mice

A Density-Dependent Target Stimulus for Inverse Bone (Re)modeling with Homogenized Finite Element Models

HR-pQCT parameters of the distal radius correlate with the bending strength of the radial diaphysis

Contact Info

Product

Resources

About