Prediction of the Presence of Fluid Accumulation in the Subcutaneous Tissue in BCRL Using Texture Analysis of Ultrasound Images

Niwa, Shiori; Mawaki, Ayana; Hisano, Fumiya; Nakanishi, Keisuke; Watanabe, Sachiyo; Fukuyama, Atsushi; Kikumori, Toyone; Shimamoto, Kazuhiro; Fujimoto, Etsuko; Oshima, Chika

doi:10.1089/lrb.2020.0121

Cited by 4 publications

(5 citation statements)

References 19 publications

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“…We are exploring quantitative measures to capture the water distribution in lymphedema using only US equipment. In a previous study, seven features of texture analysis were found to be effective in detecting fluid accumulation in lymphedema, 11 while in the present one, significant difference in complexity were found in fractal analysis using the virtual volume technique, which showed results similar to visual perception, suggesting that it is possible to assess the distribution of water in lymphedema.…”

Section: Discussionsupporting

confidence: 40%

“…As in our previous study, 11 the elbow heads of both arms were used as landmarks. Four points were scanned: (1) 5 cm proximal outside, (2) 5 cm proximal inside, (3) 5 cm distal outside, and (4) 5 cm distal inside to the olecranon in both arms of each patient.…”

Section: Methodsmentioning

confidence: 99%

“…Similar to that in previous studies, 7 , 9 , 11 the region of interest (ROI) was set in the entire subcutaneous tissue (480 pixels horizontally, arbitrary vertical direction) on each US image using ImageJ (ImageJ, FIJI) image processing software. The size of the ROI was set to enclose the entire subcutaneous tissue because this analysis method is characterized by the ability to view the entire image information within the ROI regardless of its size.…”

Section: Methodsmentioning

confidence: 99%

“…Two-dimensional MRI analysis was used by a panel of five experienced observers to determine the presence or absence of hyperintense areas, defined as follows: (1) a hyperintense area was noticed in the subcutaneous tissue around the virtual cross section in which the probe was placed; (2) the form of the hyperintense area did not matter (punctate, macular filamentous, and various other shapes); and (3) we assumed that there is no signal increase if the subcutaneous tissue does not exhibit one, even when the skin presents a signal increase. 11 …”

Section: Methodsmentioning

confidence: 99%

“…We have previously investigated fluid accumulation of subcutaneous tissue using texture analysis to evaluate it on US images. 11 Texture analysis is excellent for reproducibility and quantitative evaluation 12 , 13 ; however, it is not yet fully understood how the obtained values relate to the actual visual evaluation. Therefore, this study focuses on fractal analysis using virtual volumes, which has the characteristic of delivering results similar to human visual cognition.…”

Section: Introductionmentioning

confidence: 99%

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Exploring Indicators of Subcutaneous Tissue Fluid Accumulation in Breast Cancer-Related Lymphedema Patients Using Fractal Analysis with Virtual Volume

Niwa

Hisano

Mawaki

et al. 2023

Lymphatic Research and Biology

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Background: Breast cancer treatment sometimes causes a chronic swelling of the arm called breast cancer-related lymphedema (BCRL). Its progression is believed to be irreversible and is accompanied by tissue fibrosis and lipidosis, so preventing lymphedema from progressing by appropriate intervention at the site of fluid accumulation at an early stage is crucial. The tissue structure can be evaluated in real time by ultrasonography, and this study aims at assessing the ability of fractal analysis using virtual volume in detecting fluid accumulation within BCRL subcutaneous tissue via ultrasound imaging. Methods and Results: We worked with 21 women who developed BCRL (International Society of Lymphology stage II) after unilateral breast cancer treatment. Their subcutaneous tissues were scanned with an ultrasound system (Sonosite Edge II; Sonosite, Inc., FUJIFILM) using a 6- to 15-MHz linear transducer. Then, a 3-Tesla MR system was used to confirm fluid accumulation in the corresponding area of the ultrasound system. Significant differences in both H + 2 and complexity were observed among the three groups (with hyperintense area, without hyperintense area, and unaffected side) ( p < 0.05). Post hoc analysis (Mann–Whitney U test; Bonferroni correction p < 0.0167) revealed a significant difference for “complexity.” The evaluation of the distribution in Euclidean space showed that the variation of the distribution decreased in the order of unaffected, without hyperintense area, and with hyperintense area. Conclusion: The “complexity” of the fractal using virtual volume seems to be an effective indicator of the presence or absence of subcutaneous tissue fluid accumulation in BCRL.

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Section: Discussionsupporting

confidence: 40%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Exploring Indicators of Subcutaneous Tissue Fluid Accumulation in Breast Cancer-Related Lymphedema Patients Using Fractal Analysis with Virtual Volume

Niwa

Hisano

Mawaki

et al. 2023

Lymphatic Research and Biology

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Ultrassonografia como instrumento de avaliação do linfedema secundário ao câncer de mama: revisão sistemática

Rezende,

Piloni,

Kempa

et al. 2023

J. vasc. bras.

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Resumo O linfedema é uma doença crônica e progressiva caracterizada pelo acúmulo de fluidos, provocando edema tecidual em decorrência de um sistema linfático comprometido. A ultrassonografia diagnóstica (USD) é um método capaz de avaliar as características dos tecidos moles, podendo ser utilizada de maneira confiável para o diagnóstico do linfedema, além de mensurar a complacência tecidual em um cenário clínico. Esta é uma revisão sistemática, objetivando avaliar artigos que fizessem o uso da USD na abordagem do linfedema secundário ao câncer de mama. Foram selecionados 565 artigos, que foram exportados para o programa de revisão Rayyan QCRI e, em seguida, triados por dois pesquisadores. Dessa busca, foram obtidos 25 artigos selecionados após consenso entre os autores e que foram catalogados quanto aos seus resultados principais. A USD foi identificada como um método vantajoso por ser seguro, pouco invasivo, de baixo custo, sem uso de radiação, além de ser útil para avaliar a eficácia de terapias no tratamento do linfedema.

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Ultrasonography as an instrument to evaluate lymphedema secondary to breast cancer: systematic review

Rezende,

Piloni,

Kempa

et al. 2023

J. vasc. bras.

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Lymphedema is a chronic and progressive disease characterized by fluid accumulation, causing tissue edema as a result of a compromised lymphatic system. Diagnostic ultrasound (DUS) is a method capable of assessing soft tissue characteristics that can be used reliably to diagnose lymphedema as well as for measuring tissue compliance in a clinical setting. This is a systematic review, aiming to evaluate articles that made use of DUS in management of lymphedema secondary to breast cancer. A total of 570 articles were selected, exported to the Rayyan QCRI review program, and then screened by two researchers. From this search, 25 articles were selected after the authors reached consensus and were catalogued as to their main results. Diagnostic ultrasound was identified as an advantageous method that is safe, minimally invasive, low cost, and radiation free and is useful for evaluating the efficacy of therapies used in lymphedema treatment.

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Prediction of the Presence of Fluid Accumulation in the Subcutaneous Tissue in BCRL Using Texture Analysis of Ultrasound Images

Cited by 4 publications

References 19 publications

Exploring Indicators of Subcutaneous Tissue Fluid Accumulation in Breast Cancer-Related Lymphedema Patients Using Fractal Analysis with Virtual Volume

Exploring Indicators of Subcutaneous Tissue Fluid Accumulation in Breast Cancer-Related Lymphedema Patients Using Fractal Analysis with Virtual Volume

Ultrassonografia como instrumento de avaliação do linfedema secundário ao câncer de mama: revisão sistemática

Ultrasonography as an instrument to evaluate lymphedema secondary to breast cancer: systematic review

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