Prediction of the progression of diabetic retinopathy based on hemodynamic data

Abstract

Background. Diabetic retinopathy (DR) is a vascular complication of diabetes, leading to vision loss and blindness in people of any age. This highlights the need for monitoring and predicting the course of DR to start early timely treatment and to prevent progression to the proliferative stages of the disease. Purpose. To study the features of ocular hemodynamics and develop the progression risk index for DR. Material and Methods. One hundred and sixty-five patients with non-proliferative diabetic retinopathy (NPDR) were randomly allocated to receive traditional treatment (control group), daily tablets of Tanakan (TT group), or daily endonasal electrophoresis of Tanakan (TE group) within ten days. The stages of DR were determined using the severity scale of the Early Treatment Diabetic Retinopathy Study (ETDRS). The main outcome measures were changes in DR severity (DRS), Doppler ultrasound imaging at months 1, 3, and 6. Results. Moderate negative correlations were found between peak systolic velocity (PSV) of the central retinal artery (CRA) and DRS, end-diastolic velocity (EDV) of CRA and DRS, PSV of central retinal vein (CRV) and DRS, PSV of the short posterior ciliary artery (SPCA) and DRS. Developed diabetic retinopathy progression risk index (DRPRI) wasless than 1,0 in the TE group that enabled us to predict DR stability or improvement. Conclusions. This validation study demonstrated that PSV and DRS are correlated, and PSV can be used to diagnose the stages of DR. Developed DRPRI can be used to assess the effectiveness of treatment and to predict DR, which is essential for determining further patient management tactics.

Functional and Hemodynamic Efficacy of Non-Poliferative Diabetic Retinopathy Treatment by Endonasal Electrophoresis of Tanakan

“…As previously reported, examination of the fundus revealed a decrease in the number of hemorrhages, foci of soft and hard exudates, the disappearance of macular edema by 24.1% in the main group, and by 8.2% in the control group from baseline [15,18].…”

“…Age ranged from 20 to 75 years, women -43, men -23. The exclusion criteria were eye diseases such as inflammatory eye diseases, eye injury or intraocular surgery, glaucoma, retinal dystrophies, as well as severe somatic diseases such as glucose-galactose malabsorption, kidney or liver failure, hypertensive crisis [15].…”

Tear and serum levels of the neuromarker BDNF in type 2 diabetes mellitus patients with and without diabetic retinopathy

“…Tear BDNF levels and serum BDNF levels may be used as biomarkers of disease severity in patients with DR and as prognostic biomarkers of DR onset. We have previously studied correlations of ocular hemodynamics parameters and tear antioxidant protection with the stage of DR [13,14]. Our further research will study correlations of serum and tear levels of BDNF with the severity of DR.…”

Взаимосвязь Показателей Антиоксидантной Защиты Слезной Жидкости И Стадий Диабетической Ретинопатии

“…Для выяснения взаимосвязей между содержанием оксида азота и показателями ПОЛ-АОС нами был вычислен коэффициент корреляции [14]. У практически здоровых лиц выявлено наличие положительной умеренной корреляции между уровнем оксида азота и МДА (r=0.58) и отрицательной связи с активностью каталазы (r=0.63), а также положительные связи между активностью ферментов каталазы и СОД (r=0.55).…”