Prediction of treatment responses to neoadjuvant chemotherapy in breast cancer using contrast-enhanced ultrasound

Huang, Yao Qi; Jian, Le; Miao, Aiyu; Zhi, Wenxiang; Wang, Fen; Chen, Yaling; Zhou, Shichong; Chang, Cai

doi:10.21037/gs-20-836

Cited by 14 publications

(13 citation statements)

References 39 publications

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“…Jia et al demonstrated that CEUS provides useful information regarding tumor blood perfusion changes and distribution features 24,25 . The capability of CEUS to accurately estimate tumor response after NAC in patients with breast cancer has been previously reported 26,27 .…”

Section: Discussionmentioning

confidence: 98%

“…Jia et al demonstrated that CEUS provides useful information regarding tumor blood perfusion changes and distribution features. 24 , 25 The capability of CEUS to accurately estimate tumor response after NAC in patients with breast cancer has been previously reported. 26 , 27 In the present study, CEUS predicted the pathological response after NAC with AUC value of 0.848, demonstrating significant potential as a detection method for pCR.…”

Section: Discussionmentioning

confidence: 99%

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Prediction of pathological complete response to neoadjuvant chemotherapy in patients with breast cancer using a combination of contrast‐enhanced ultrasound and dynamic contrast‐enhanced magnetic resonance imaging

et al. 2022

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This study aimed to evaluate the value of dynamic contrast‐enhanced ultrasound (CEUS) combined with dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) in predicting pathological complete response (pCR) in patients with breast cancer receiving neoadjuvant chemotherapy (NAC). Fifty‐seven female patients with breast cancer (mean age, 50.46 years; range, 32–66 years) scheduled for NAC were recruited. CEUS and DCE‐MRI were performed before and after NAC. Imaging features and their changes were compared with postoperative pathological results. After the clinical differences were balanced using propensity score matching, univariate and multiple logistic regression analyses were used to derive the characteristics independently associated with pCR. Receiver operating characteristic curve analysis was performed to assess diagnostic performance. After six to eight cycles of NAC, 24 (42.1%) patients achieved pCR, while 33 (57.9%) did not. Multivariate analysis showed that enhancement order on CEUS and DCE‐MRI before NAC, reduction in diameter and enhancement shape on CEUS, maximum diameter on DCE‐MRI, and the type of progressive dynamic contrast enhancement after NAC were independently associated with pCR after NAC. The area under the receiver operating characteristic curve for CEUS+DCE‐MRI was 0.911 (95% confidence interval, 0.826–0.997), and the specificity and positive predictive values were 87.0% and 87.5%. CEUS and DCE‐MRI have the potential for assessing the pathological response to NAC in patients with breast cancer; their combination showed the best diagnostic performance. CEUS+DCE‐MRI has proved beneficial for comprehensive assessment and personalizing treatment strategies for patients with breast cancer.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Prediction of pathological complete response to neoadjuvant chemotherapy in patients with breast cancer using a combination of contrast‐enhanced ultrasound and dynamic contrast‐enhanced magnetic resonance imaging

et al. 2022

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“…BC patients who obtained pRC after complete NAC showed a significant decrease in peak intensity (PI) [19] [20], ascending slope (AS) [20], time to peak (TTP) [19] and another index, mean transition time(MTT) [20]was significantly increased, on time intensity curve analysis. Some investigators, in order to predict NAC efficacy early, found that BC patients who obtained a good response group (Miller-Payne score 4 or 5) after the first NAC cycle had significantly lower PI [21] and significantly higher TTP [22] and rasing time (RT) [22], and lesions had reduced blood supply and tumor neovascularization after one NAC cycle.…”

Section: Contrast-enhanced Ultrasonography For Response Evaluation To...mentioning

confidence: 99%

Application Progress of Conventional and New Techniques of Ultrasound in Prediction of Neoadjuvant Chemotherapy Response in Breast Cancer

2023

JCMP

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The incidence and mortality rate of breast cancer in women currently ranks first worldwide. Neoadjuvant chemotherapy is increasingly used to improve the feasibility and success rate of breast conserving surgery, but neoadjuvant chemotherapy is ineffective to some patients. Ineffective neoadjuvant chemotherpy may delay surgical treatment. At present, various ultrasound techniques have been widely used in prediction of neoadjuvant chemotherapy response in breast cancer. This paper reviews the role and development of conventional and new ultrasound techniques in the efficacy evaluation of neoadjuvant chemotherapy for breast cancer.

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“…Huang et al. ( 34 ) also identified CEUS as a potential tool for predicting NAC response in locally advanced breast cancer patients. Compared with other molecular subtypes, triple-negative and HER2+/ER- subtypes responded better to NAC.…”

Section: Evaluation Of the Efficacy Of Ultrasound On Nac In Breast Ca...mentioning

confidence: 99%

Advances in Imaging in Evaluating the Efficacy of Neoadjuvant Chemotherapy for Breast Cancer

Kong

Zhang

et al. 2022

Front. Oncol.

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Neoadjuvant chemotherapy (NAC) is increasingly widely used in breast cancer treatment, and accurate evaluation of its response provides essential information for treatment and prognosis. Thus, the imaging tools used to quantify the disease response are critical in evaluating and managing patients treated with NAC. We discussed the recent progress, advantages, and disadvantages of common imaging methods in assessing the efficacy of NAC for breast cancer.

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Prediction of treatment responses to neoadjuvant chemotherapy in breast cancer using contrast-enhanced ultrasound

Cited by 14 publications

References 39 publications

Prediction of pathological complete response to neoadjuvant chemotherapy in patients with breast cancer using a combination of contrast‐enhanced ultrasound and dynamic contrast‐enhanced magnetic resonance imaging

Prediction of pathological complete response to neoadjuvant chemotherapy in patients with breast cancer using a combination of contrast‐enhanced ultrasound and dynamic contrast‐enhanced magnetic resonance imaging

Application Progress of Conventional and New Techniques of Ultrasound in Prediction of Neoadjuvant Chemotherapy Response in Breast Cancer

Advances in Imaging in Evaluating the Efficacy of Neoadjuvant Chemotherapy for Breast Cancer

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