Concrete filled steel tubes (CFSTs) show advantageous applications in the field of construction, especially for a high axial load capacity. The challenge in using such structure lies in the selection of many parameters constituting CFST, which necessitates defining complex relationships between the components and the corresponding properties. The axial capacity (P u ) of CFST is among the most important mechanical properties. In this study, the possibility of using a feedforward neural network (FNN) to predict P u was investigated. Furthermore, an evolutionary optimization algorithm, namely invasive weed optimization (IWO), was used for tuning and optimizing the FNN weights and biases to construct a hybrid FNN-IWO model and improve its prediction performance. The results showed that the FNN-IWO algorithm is an excellent predictor of P u , with a value of R 2 of up to 0.979. The advantage of FNN-IWO was also pointed out with the gains in accuracy of 47.9%, 49.2%, and 6.5% for root mean square error (RMSE), mean absolute error (MAE), and R 2 , respectively, compared with simulation using the single FNN. Finally, the performance in predicting the P u in the function of structural parameters such as depth/width ratio, thickness of steel tube, yield stress of steel, concrete compressive strength, and slenderness ratio was investigated and discussed.Materials 2020, 13, 1205 2 of 25 larger energy absorption capacity [7], convenient construction [11], economy of materials [12][13][14], and excellent seismic and refractory performance [15]. In particular, this type of structure can reduce the environmental burden by removing formwork [16], reusing steel pipes, and using high quality concrete with recycled aggregate [17]. The characteristics of CFST are that the steel material is located far from the central axis so the rigidity of the column is very large, and thus it also contributes to increasing the moment of inertia of the structure [5,18]. The ideal form of concrete core works against the compressive load and hinders the local buckling state of the steel pipe. Therefore, the CFST structures are often used in locations subject to large compressive loads [9,15,19]. The CFST columns are mainly divided into square columns, round columns, and rectangular columns, based on different cross-sectional forms [15]. In particular, the square and rectangular CFST columns have the advantage of easy connection and reliable work with other structural members such as beams, walls, and panels [20]. Compared with square CFST columns, rectangular columns have irregular bending stiffness along different axes, so this type of column is suitable for the mechanical behavior of members including arch ribs, pillars, abutments, and piers, and other structural members under load actions vary greatly from vertical to horizontal [6]. Because the scope of application of rectangular CFST columns is quite wide and this column is mainly subjected to compression, the main purpose of the paper is to analyze and evaluate the ultimate bearing capacity of...