Prediction of wall stress and oxygen flow in patient-specific abdominal aortic aneurysms: the role of intraluminal thrombus

The mechanism and therapy of aortic aneurysms

“…Overall, the effect of ILT on AA remains pathological rather than protective. 127 , 133 Therefore, anticoagulant treatment could reduce ILT assessment and demonstration, but whether it can reduce the possibility of AAA rupture requires further study. 134 Because of the property of ILT to promote AA rupture, several studies have shown that ILT measurement by CT or three-dimensional contrast-enhanced ultrasound can predict the risk of AAA rupture and could be used for clinical purposes.…”

Analyzing the contribution of vasa vasorum in oxygenation of the aneurysmal wall: A computational study

“…Additionally, the aortic wall concentration decreases significantly at the portion that is in contact with the ILT. By comparing the simulated results for the baseline case with the previous in situ and in vitro measurements of wall oxygenation, we have previously validated the oxygen transport model in [18] . Specifically, comparisons are made with measurements of oxygen tension in surgically removed AAA wall specimens [13] and the partial pressures of oxygen in a dog’s abdominal aorta [50] .…”

“…Additionally, in prior studies on the importance of hypoxia in vascular mechanics and its potential link to aneurysm progression, the significance of various oxygen transport parameters in AAA context are quantified [14] , [16] , [17] . In particular, using a fluid-structure interaction (FSI) methodology, the impact of the ILT presence on oxygen flow in patient-specific aneurysm models is identified in [18] , while the relationship between ILT and aneurysm geometrical variations with localized oxygen starvation in idealized AAA models is demonstrated in [19] . A similar study was performed in [20] on a patient-specific AAA geometry to observe the effects of ILT porosity and its permeability on oxygen delivery.…”

“…The open-source software Gmsh [47] is adopted to discretize the three computational domains, namely, blood, ILT and the aneurysmal wall; using linear tetrahedral elements. To ensure an optimally sized discretization, mesh convergence analysis is carried out in the same manner to the previous research in [18] . Particularly, the sensitivity test is accomplished by increasing the number of elements and conducting the simulations with refined grid density until the re-calculated model predictions agreed well with that from the original mesh.…”

Rupture risk parameters upon biomechanical analysis independently change from vessel geometry during abdominal aortic aneurysm growth

“… 22 A large movement of the point of the maximum ILT thickness during aneurysm growth might, therefore, be linked to an increase in risk of rupture based on previous similar speculations. 9 , 21 , 23 …”