Predictions and associations of fatigue syndromes and mood disorders that occur after infectious mononucleosis

Predictors of fatigue following the onset of infectious mononucleosis

“…Buchwald and colleagues (2000) found self-report of non-recovery at 2 months was best determined by biological factors, whereas the 6 months predictors represented a more complex mix of psychological and social factors. In White and colleagues' cohort the most reliable predictor of fatigue syndrome to 6 months after onset was poorer physical fitness (White et al 2001), a variable we did not test in the present study. These studies explored different predictors and outcomes, but like us they both found that the predictors of poor outcome depended on when the outcome was measured.…”

“…There are a number of possible mechanisms that could explain this association. Psycho-behavioural mechanisms have been postulated for fatigue following severe infections, and there is some evidence that individuals who have a history of previous psychiatric disorder (Hotopf et al 1996) ; physical attributional style (Cope et al 1994) ; greater adverse life events (Buchwald et al 2000) ; greater family support (Buchwald et al 2000) ; and lower fitness (White et al 2001) are at greater risk of poorer outcomes. In a recent systematic review the most consistent factor found for delayed recovery in IM was reduced physical functioning (Candy et al 2003).…”

Routine Epstein-Barr Virus Diagnostics from the Laboratory Perspective: Still Challenging after 35 Years

“…Formerly, EBV was suspected to be the major cause of chronic fatigue syndrome on the basis of a "highly unusual serologic profile" (29). However, no authentic link of chronic fatigue syndrome to EBV infection has been shown (29) and additional cofactors and potential causes are being discussed (36). Therefore, the diagnosis of primary or acute infection is relevant.…”

Chronisch-vermoeidheidssyndroom

“…106 The possibility that CFS is associated with an infection has been established. 107,108 In their systematic review, Bagnall et al 1 included RCTs which investigated the effects of different immunological or antiviral treatments on CFS patients: antihistamine (oral Terfenadine 109 ), antiviral (Acyclovir, 110 Gancyclovir, 111 Inosine Pranobex 112 ), immunomodulators (Immunoglobulin, [113][114][115] Interferon, 116 Alpha Interferon, 117 leucocyte extract, 85 Ampligen 118 ) and vaccine (Staphylococcus toxoid 119,120 ).…”