Predictive Ability of Blood Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Gastrointestinal Stromal Tumors

Racz, Jennifer M.; Cleghorn, Michelle C.; Jimenez, M. Carolina; Atenafu, Eshetu G.; Jackson, Timothy; Okrainec, Allan; Venkatraghavan, Lakshmikumar; Quereshy, Fayez A.

doi:10.1245/s10434-014-4265-6

Cited by 52 publications

(56 citation statements)

References 34 publications

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“…The results in our present study showed that high level of PLR was associated with poor prognosis of GISTs. This was consistent with the studies reported by Racz et al 14 and Goh et al 16 …”

Section: Discussionsupporting

confidence: 93%

“…Among them, Perez et al 12 Atila et al, 13 Kargin et al, 15 and Goh et al 16 showed that high level of NLR was correlated with poor prognosis of GISTs. No correlation between NLR and prognosis of GISTs was found in the study reported by Racz et al 14 This may attribute to the relatively small sample size of the study. In our present study, we also found that high NLR was associated with poor prognosis of GISTs.…”

Section: Discussionmentioning

confidence: 59%

“…14 Furthermore, superiority of PLR over NLR as an independent prognostic factor has been demonstrated in ovarian, 27 colon, 28 and esophageal cancer. 29 However, these studies did not provide a reasonable explanation for the results.…”

Section: Discussionmentioning

confidence: 99%

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Combination of PLR, MLR, MWR, and Tumor Size Could Significantly Increase the Prognostic Value for Gastrointestinal Stromal Tumors

et al. 2016

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Systemic inflammation and immune response were associated with prognosis of tumors. However, data was limited due to the relatively low incidence of gastrointestinal stromal tumors (GISTs). The aim of the present study was to investigate the predictive value of preoperative peripheral blood cells in prognosis of GISTs.From September 2008 to July 2015, a total of 274 GIST patients in our department were enrolled in the present study. Clinicopathological features of GISTs were recorded. The association between preoperative peripheral blood cells and prognosis of GISTs were analyzed.Tumor location, tumor size, mitotic index, intratumoral necrosis, and National Institutes of Health (NIH) risk category were associated with prognosis of GISTs. High neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), neutrophil-to-white blood cell ratio (NWR), monocyte-to-white blood cell ratio (MWR) and low lymphocyte-to-white blood cell ratio (LWR) was associated with poor prognosis of GISTs (76.2% vs 83.7%, P = 0.010. 70.5% vs 98.7%, P = 0.000. 65.7% vs 96.4%, P = 0.004. 78.5% vs 82.5%, P = 0.044. 73.5% vs 97.8%, P = 0.004. 76.6% vs 83.6%, P = 0.012, respectively). However, tumor size was the only independent risk factor for prognosis according to multivariate analysis (P = 0.006). Tumor location, tumor size, mitotic index, and NIH risk category were significantly correlated with the above-mentioned parameters (all P < 0.05). The prognosis of GISTs with tumor size >5 cm, high MLR, high PLR, and high MWR was significantly lower than the remnant patients (P = 0.010).The peripheral blood routine test is convenient, reproducible, and inexpensive. High NLR, MLR, PLR, NWR, MWR, and low LWR were associated with poor prognosis of GISTs. The association between the above parameters and prognosis of GISTs may be attributed to their correlation with tumor size, mitotic index, and NIH risk category. The combination of tumor size, MLR, PLR, and MWR could further increase the predictive value of prognosis of GISTs.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 59%

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Combination of PLR, MLR, MWR, and Tumor Size Could Significantly Increase the Prognostic Value for Gastrointestinal Stromal Tumors

et al. 2016

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“…Thus, a cutoff point simply determined by ROC curve in our study may not be appropriate to estimate the prognostic value of platelet counts. PLR, which take both protumor status and antitumor immune status into consideration, has emerged as an independent prognostic factor in many cancers . However, there were no studies regarding its prognostic role in NPC.…”

Section: Discussionmentioning

confidence: 99%

Pretreatment hematologic markers as prognostic factors in patients with nasopharyngeal carcinoma: Neutrophil‐lymphocyte ratio and platelet‐lymphocyte ratio

et al. 2015

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“…Therefore, in the last few years, the combination of inflammatory markers or inflammation-based prognostic scores, including the neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) 7-9, lymphocyte monocyte ratio (LMR) 10, and prognostic nutritional index (PNI) 11, have been reported to have prognostic value in patients with various cancer.…”

Section: Introductionmentioning

confidence: 99%

C-Reactive Protein/Albumin Ratio (CAR) as a Prognostic Factor in Patients with Non-Metastatic Nasopharyngeal Carcinoma

Wang

Chen

et al. 2016

J. Cancer

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Background: The C-reactive protein/albumin (CRP/ALB) ratio has recently been associated with clinical outcomes in patients suffering various types of cancer. In this retrospective study, we investigated the prognostic value of the pre-treatment CRP/ALB ratio (CAR) in non-metastatic nasopharyngeal carcinoma (NPC) patients.Methods: The cohort included 2685 patients with non-metastatic NPC. Univariate and multivariate COX proportional hazards analyses were applied to evaluate the associations of CAR with overall survival (OS), distant metastasis-free survival (DMFS), disease-free survival (DFS), and locoregional recurrence-free survival (LRRFS) in patients with NPC. Kaplan-Meier survival analyses was used to compare groups classified by CAR.Results: Patients were categorised by the CAR using a cut-off value of 0.064. Multivariate Cox proportional hazard analysis verified that high CAR level was a significant predictor for inferior OS (P = 0.003), DMFS (P = 0.035), and LRRFS (P = 0.024), but not for DFS (P = 0.093). CAR was also an independent prognostic factor for OS when stratified by Epstein-Barr virus DNA level ( ≥ 2560 or < 2560 copies ml-1).Conclusions: High CAR provides prognostication regarding OS, DMFS, DFS, and LRRFS in patients with NPC. CAR is a valuable coadjutant for Epstein-Barr virus DNA levels for identifying survival differences.

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Predictive Ability of Blood Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Gastrointestinal Stromal Tumors

Abstract: High PLR was associated with reduced RFS. The prognostic ability of PLR to predict recurrence suggests that it may play a role in risk-stratification schemes used to determine which patients will benefit from adjuvant therapy.

Cited by 52 publications

References 34 publications

Combination of PLR, MLR, MWR, and Tumor Size Could Significantly Increase the Prognostic Value for Gastrointestinal Stromal Tumors

Combination of PLR, MLR, MWR, and Tumor Size Could Significantly Increase the Prognostic Value for Gastrointestinal Stromal Tumors

Pretreatment hematologic markers as prognostic factors in patients with nasopharyngeal carcinoma: Neutrophil‐lymphocyte ratio and platelet‐lymphocyte ratio

C-Reactive Protein/Albumin Ratio (CAR) as a Prognostic Factor in Patients with Non-Metastatic Nasopharyngeal Carcinoma

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