This paper introduces a new development for designing a Multi-Input Multi-Output (MIMO) Fuzzy Optimal Model Predictive Control (FOMPC) using the Adaptive Particle Swarm Optimization (APSO) algorithm. The aim of this proposed control, called FOMPC-APSO, is to develop an efficient algorithm that is able to have good performance by guaranteeing a minimal control. This is done by determining the optimal weights of the objective function. Our method is considered an optimization problem based on the APSO algorithm. The MIMO system to be controlled is modeled by a Takagi-Sugeno (TS) fuzzy system whose parameters are identified using weighted recursive least squares method. The utility of the proposed controller is demonstrated by applying it to two nonlinear processes, Continuous Stirred Tank Reactor (CSTR) and Tank system, where the proposed approach provides better performances compared with other methods.