Predictive Effects of Inflammatory Scores in Patients with BCLC 0-A Hepatocellular Carcinoma after Hepatectomy

Huang, Pao‐Yuan; Wang, Chih‐Chi; Lin, Chen-Si; Lu, Sheng–Nan; Wang, Jing‐Houng; Hung, Chao‐Hung; Kee, Kwong‐Ming; Chen, Chien‐Hung; Chen, Kuang‐Den; Hu, Tsung–Hui; Tsai, Ming-Chao

doi:10.3390/jcm8101676

Cited by 26 publications

(29 citation statements)

References 44 publications

(45 reference statements)

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“…www.nature.com/scientificreports/ of cancer patients [16][17][18][19][20][21][22] . Malnutrition and low immune function not only affect the treatment effect of patients with malignant tumors, but also make malignant tumors more prone to relapse and metastasis 17 .…”

Section: Discussionmentioning

confidence: 99%

“…Compared with patients with normal nutritional status and immune function, the prognosis of those with poor nutritional status and immune function are also poor. A large number of studies have shown that immune nutrition status can be used as a powerful indicator to predict the survival outcome of patients with malignant tumors [19][20][21][22] . Onodera first confirmed the prognostic role of PNI in gastrointestinal surgery of malnourished cancer patients in 1984 23 .…”

Section: Discussionmentioning

confidence: 99%

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The role of prognostic nutritional index for clinical outcomes of gastric cancer after total gastrectomy

Zhao

Feiyan

Liang

et al. 2020

Sci Rep

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The purpose of this article is to evaluate the relationship between the nutrition-based microenvironment and clinicopathological information for gastric cancer patients and to investigate the prognostic value of nutrition index for gastric cancer patients undergoing total gastrectomy. We retrospectively collected clinical information of 245 gastric cancer patients who underwent total gastrectomy in our hospital between January 1st 2005 and December 30th 2015. According to the prognostic nutritional index (PNI) level, they were divided into low PNI (< 43) group and high PNI (≥ 43) group. The relationship between PNI and the disease-free survival (DFS) and overall survival (OS) were analyzed by statistical analysis. Univariate analyses demonstrated that TNM stage (p = 0.025), patients age (p = 0.042), lymph node metastasis (p = 0.028), tumor differentiation (p = 0.037) and a low PNI (p = 0.033) were closely correlated with a poor prognosis. In multivariate analysis, TNM stage (p = 0.027) and a low PNI (p = 0.041) were found to be independently associated with poor survival. Additionally, when age was considered as a stratified factor, univariate analyses demonstrated that low PNI correlated with shorter DFS in non-elderly (< 65) patients (p = 0.022) and shorter DFS (p = 0.036) and OS (p = 0.047) in elderly (≥ 65) patients. The low prognostic nutritional index is an independent risk factor associated with poor gastric cancer survival which represents the nutritional microenvironment. Patients with low pre-operative prognostic nutritional index levels should be observed more closely after surgery to prevent the occurrence of post-operative complications in the near future.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The role of prognostic nutritional index for clinical outcomes of gastric cancer after total gastrectomy

Zhao

Feiyan

Liang

et al. 2020

Sci Rep

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“…5 For the patients with early-stage HCC, predictive models based on platelet count (PLT) are effective in evaluating the recurrence after curative resection. [6][7][8] While for huge HCC (diameter over 10 cm), a tumour subgroup of intermediate-stage (BCLC-B) HCC, high PLT is associated with an increased risk of distant metastasis after transarterial chemoembolization (TACE). 9 In line with this finding, another large retrospective study showed that thrombocytopenia is associated with favourable outcomes in patients with unresectable HCC.…”

Section: Introductionmentioning

confidence: 99%

<p>Elevated Platelet Count is Associated with Poor Survival After Transarterial Chemoembolization Treatment in Patients with Hepatocellular Carcinoma: A Cohort Study</p>

Zhang

Zheng

et al. 2020

JHC

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Background: Platelet count (PLT) has been proved as an essential biomarker for the survival of hepatocellular carcinoma (HCC). However, the prognostic value of PLT change (ΔPLT) is still uncertain. The aim of this study was to explore the relationship between ΔPLT and HCC survival after transarterial chemoembolization (TACE) treatment. Methods: Cox proportional hazard regression models were used to calculate multivariableadjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for HCC. The non-linear relationship between ΔPLT and OS was estimated through a restricted cubic spline regression analysis, and a two-piece-wise Cox proportional hazard model was further performed to calculate the threshold effect. Results: A total of 597 HCC patients treated with TACE were selected for the secondary analysis. Compared with the ΔPLT within ±20 (×10 9 /L), ΔPLT≥20 (×10 9 /L) was significantly associated with an 64% increase in risk of death (HR, 1.64; 95% CI: 1.21 to 2.22) after adjustment for confounding variables, but the association was not significant in the group of ΔPLT≤-20 (HR, 1.23; 95% CI: 0.92 to 1.63). We also found a U-shape relationship between ΔPLT and HCC survival at the turning point of ΔPLT as 0 (20×10 9 /L). The HR for the death was 1.12 (95% CI: 1.06, 1.18) with ΔPLT≥0 (20×10 9 /L) while 0.95 (95% CI: 0.92, 0.98) with ΔPLT<0 (20×10 9 /L). After potential confounding factors were adjusted, the non-linear relationship between ΔPLT and OS was still significant (P=0.013). Besides, ΔPLT≥20 (×10 9 / L) was associated with new lesions (OR, 2.74; 95% CI: 1.38 to 5.45). Conclusion: Elevated PLT was associated with poor overall survival of HCC patients after TACE treatment.

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“…Seven studies (5,7,(9)(10)(11)(12)(13) reported the relationship between SII and vascular invasion (including MVI). Considering that there was significant heterogeneity (I 2 : 85.8%, P=0.000), the random effect model was adopted.…”

Section: Relationship Between Preoperative Sii and Vascular Invasionmentioning

confidence: 99%

The value of preoperative systemic immune-inflammation index in predicting vascular invasion of hepatocellular carcinoma: a meta-analysis

Shao

2021

Braz J Med Biol Res

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Vascular invasion and systemic immune-inflammation index (SII) are risk factors for the prognosis of patients with hepatocellular carcinoma. At present, the correlation between the two is not clear. This meta-analysis explored the relationship between preoperative SII and vascular invasion in patients with hepatocellular carcinoma. According to the search formula, the Pubmed, Embase, Cochrane, Web of Science, and CNKI databases were searched for the relevant research until March 2020. After the quality evaluation of the included literature, the odds ratio (OR) and its corresponding 95% confidence interval (CI) were used as the effect measure. Stata 15. 0 software was used for statistical analysis. The meta-analysis eventually included seven retrospective cohort studies of 3583 patients with hepatocellular carcinoma. The results showed that the choice of SII cutoff value affects SII's efficiency in predicting the risk of vascular invasion. In the cohort of studies with appropriate SII cutoff value, the high SII preoperative group had a higher risk of vascular invasion (OR=2.62; 95%CI: 2.07-3.32; P=0.000) and microvascular invasion (OR=1.82; 95%CI: 1.01-3.25; P=0.045) than the low SII group. The tumor diameter (OR=2.88; 95%CI: 1.73-4. 80; P=0.000) of the high SII group was larger than that of the low SII group. There was no publication bias in this study (Begg's test, P=0.368). As a routine, cheap, and easily available index, SII can provide a certain reference value for clinicians to evaluate vascular invasion before operation.

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Predictive Effects of Inflammatory Scores in Patients with BCLC 0-A Hepatocellular Carcinoma after Hepatectomy

Cited by 26 publications

References 44 publications

The role of prognostic nutritional index for clinical outcomes of gastric cancer after total gastrectomy

The role of prognostic nutritional index for clinical outcomes of gastric cancer after total gastrectomy

<p>Elevated Platelet Count is Associated with Poor Survival After Transarterial Chemoembolization Treatment in Patients with Hepatocellular Carcinoma: A Cohort Study</p>

The value of preoperative systemic immune-inflammation index in predicting vascular invasion of hepatocellular carcinoma: a meta-analysis

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