Predictive factors for local recurrence after glansectomy and neoglans reconstruction for penile squamous cell carcinoma

Albersen, Maarten; Parnham, A.; Sahdev, Varun; Christodoulidou, Michelle; Nigam, Raj; Freeman, A.; Jameson, Charles; Minhas, S.; Ralph, David; Malone, Peter R.; Muneer, A.

doi:10.1016/s1569-9056(17)30767-4

Cited by 8 publications

(11 citation statements)

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“…The NCDB does not provide information as to when the lymph node dissection was performed. While the literature shows an association between positive surgical margin status and local recurrence, no study has evaluated the relationship between surgical margin status and lymph node involvement . This might be related to the short time period between primary surgical excision of the tumour and subsequent lymph node dissection that is often standard of care.…”

Section: Discussionmentioning

confidence: 99%

A National Cancer Database‐based nomogram to predict lymph node metastasis in penile cancer

et al. 2019

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ObjectiveTo evaluate the predictive nature of several clinicopathological variables by developing a nomogram predictive for lymph node-positive disease using the National Cancer Database cohort of patients with squamous cell carcinoma of the penis. MethodsStepwise logistic regression was used to find the best-fit model; remaining clinical variables were used to create a nomogram to predict the probability of lymph node-positive disease. ResultsOn multivariate analysis, high pathological grade (3-4 vs 1: odds ratio [OR] 3.27, 95% confidence interval [CI] 1.70-6.29; 2 vs 1: OR 2.58, 95% CI 1.39-4.79 [P = 0.002]), lymphovascular invasion (OR 2.49, 95% CI 1.61-3.84 [P < 0.001]), and positive clinical lymph node status (N1 vs N0: OR 20.0, 95% CI 11.4-35.7; N2 vs N0: OR 27.8, 95% CI 14.1-55.6; N3 vs N0: OR 49.2, 95% CI 14.8-162.8 [P < 0.001]) were predictors of lymph node metastasis in penile cancer. The bootstrap-corrected concordance index of this nomogram was 0.880. ConclusionUsing tumour grade, tumour lymphovascular invasion and clinical lymph node status, we developed a nomogram highly predictive of pathologial lymph node metastasis that, after further external validation, could be helpful in the surgical decision-making process.

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Section: Discussionmentioning

confidence: 99%

A National Cancer Database‐based nomogram to predict lymph node metastasis in penile cancer

et al. 2019

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“…Therefore, patients presenting with Tis, Ta, and T1 G1-3 disease may benefit from conservative treatment. However, they have a higher risk of local recurrence, and physicians must closely monitor these patients through follow-up, especially when presenting perineural invasion, Tis, positive definitive margins, and high-grade tumors (Albersen et al 2018). Besides, organ-sparing surgery does not provide a significant difference in overall survival compared with total or partial penectomy (Lindner et al 2019;Djajadiningrat et al 2014a, b).…”

Section: T1 Tumorsmentioning

confidence: 99%

Penile cancer: a Brazilian consensus statement for low- and middle-income countries

Soares

Carvalho

Fonseca³

et al. 2020

J Cancer Res Clin Oncol

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Purpose Penile cancer is highly prevalent in low- and middle-income countries, with significant morbidity and mortality rates. The first Brazilian consensus provides support to improve penile cancer patients’ outcomes, based on expert’s opinion and evidence from medical literature. Methods Fifty-one Brazilian experts (clinical oncologists, radiation oncologists, urologists, and pathologists) assembled and voted 104 multiple-choice questions, confronted the results with the literature, and ranked the levels of evidence. Results Healthcare professionals need to deliver more effective communication about the risk factors for penile cancer. Staging and follow-up of patients include physical examination, computed tomography, and magnetic resonance imaging. Close monitoring is crucial, because most recurrences occur in the first 2–5 years. Lymph-node involvement is the most important predictive factor for survival, and management depends on the location (inguinal or pelvic) and the number of lymph nodes involved. Conservative treatment may be helpful in selected patients without compromising oncological outcomes; however, surgery yields the lowest rate of local recurrence. Conclusion This consensus provides an essential decision-making orientation regarding this challenging disease.

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“…In a retrospective study, Albersen et al identified four risk factors for LR in a univariate model: perineural invasion, carcinoma in situ, positive margins on definitive pathology, and the presence of highgrade SCC. None of these risk factors was a significant predictor of LR in multivariate cox regression 16 . These findings contrast with our results.…”

Section: Discussionmentioning

confidence: 86%

Factores asociados a recurrencia locoregional en cáncer de pene: un estudio de casos y control

Zárate-González¹,

Priego-Niño²,

Salgado-Arroyo³

et al. 2021

CIRU

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Purpose: Surgical excision of the primary tumor in penile cancer (PC) has shown good local control with a risk of locoregional recurrence (LR) of 4-8%. The magnitude of such risk and the characteristics that distinguish patients who develop LR from those who do not is controversial. Our goal was to estimate, clinical and oncological characteristics, and outcome of LR in a cohort of patients with PC. Materials and methods: A retrospective, case-control study of ten patients with LR of PC and ten controls. Using a multivariate analysis for clinical and oncological characteristics was evaluated to determine their association with LR. Results: Cases and controls were similar in regards to the prevalence of diabetes, age, grade of differentiation, presence of lymphovascular invasion (LVI), and positive margins. In our multiple logistic regression analysis clinical stage (CS), LVI and positive margins were associated with LR. Time to LR had a median of 15 months. Conclusions: Our study confirms that patients with advanced CS, LVI and positive margins after surgical excision of the primary tumor could have higher risk of LR. We believe that a close oncological follow-up should be done in patients with adverse oncological characteristics.

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Predictive factors for local recurrence after glansectomy and neoglans reconstruction for penile squamous cell carcinoma

Cited by 8 publications

References 0 publications

A National Cancer Database‐based nomogram to predict lymph node metastasis in penile cancer

A National Cancer Database‐based nomogram to predict lymph node metastasis in penile cancer

Penile cancer: a Brazilian consensus statement for low- and middle-income countries

Factores asociados a recurrencia locoregional en cáncer de pene: un estudio de casos y control

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