Predictive Factors of Deep Vein Thrombosis in Gynecologic Cancer Survivors with Lower Extremity Edema: A Single-Center and Retrospective Study

Abstract

This study was conducted to examine predictive factors of deep vein thrombosis (DVT) in gynecologic cancer survivors with lower extremity edema (LEE). In the current single-center, retrospective study, there was a total of 315 eligible patients, including 80 patients with DVT and 235 without DVT. They were therefore divided into two groups: the DVT group (n = 80) and the non-DVT group (n = 235). Then, baseline and clinical characteristics of the patients were compared between the two groups. In our study, distant organ metastasis, advanced stage, lymphadectomy, and amount of intraoperative blood loss had a positive predictive value for the occurrence of DVT in gynecologic cancer survivors presenting LEE. In conclusion, our results indicate that it is necessary to consider the possibility of LEE arising from DVT in gynecologic cancer survivors with advanced-stage cancer, distant organ metastasis, lymphadectomy, and intraoperative blood loss over 1500 mL.

Analysis of Risk Factors of Postoperative Lower Extremity Deep Venous Thrombosis in Patients With Cervical Cancer

“…However, retrospective research analyzed 135 gynecological cancer survivors and found that the incidence of DVT in lower limbs was 25.4%. 27 Undeniably, the varied study design standards and the dearth of multicenter or big sample data studies may be to blame for these differences. In addition, 14 DVT patients developed pulmonary embolism in our research.…”

The factors affecting the survivability of malignant cancer patients with deep vein thrombosis among subjects with gynecologic and non-gynecologic cancer: An ambispective cohort study

“…Thereby, after the distant metastasis, tumor cells interact with the hemostatic system, which emphasizes that hypercoagulability already exists in patients with localized cancer spread. 55 Studies have shown that detecting cancer at an early stage can significantly improve the chances of survival. However, over 50% of cancer cases are diagnosed at an advanced stage.…”

“…Studies have shown that the risk of DVT in women undergoing gynecologic surgery is estimated to be between 17-40%. 55 The relationship between gynecologic cancers and thrombotic events is believed to be linked to lymphadenectomy and venous congestion caused by tumors or enlarged lymph nodes. 70 Lymphadenectomy is a frequently utilized procedure in the evaluation of lymph node status and staging of gynecologic malignancies, as well as a therapeutic intervention for patients with gynecologic cancer.…”

“…A literature review indicates that the incidence of VTE after lymphadenectomy ranges from 0.8% to 25%. 55 A large cohort study conducted by Chew et al, revealed that the incidence of DVT in cancer patients is linked to a 3.7-fold rise in mortality risk. 71 The identification of DVT as a major risk factor has been established for decreased survival in cancer patients.…”