Predictive Factors of Treatment Outcomes for Hospital Care in Children with Acute Methadone Poisoning

Atighi, Yasamin; Eizadi-Mood, Nastaran; Mansourian, Marjan; Zamani, Amin; Saffaei, Ali; Sabzghabaee, Ali Mohammad

doi:10.4103/jrpp.jrpp_16_141

Cited by 4 publications

(2 citation statements)

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“…28,38 As mentioned previously, some Iranian MMT centers unfortunately provide take-home doses of methadone in unsafe containers, such as mineral water bottles, despite the evidence that opioids are potentially lethal substances and more than 80% of poisonings occur at home accidentally. 24,25,30,36,37,40 Although supervised daily methadone consumption is an established practice in many countries, the US and other countries have recently loosened regulations to allow for take-home doses of methadone of up to 28 days because of COVID-19 guidelines. 41 This decision seems sensible and necessary, but its impact on community-based poisoning is yet to be seen.…”

Section: Discussionmentioning

confidence: 99%

“…In both Iran and the US, the trend of pediatric opioid poisoning has increased along with access to prescribed or illicit opioids, and it is hoped that the 2 countries can learn from each other’s public health responses to this issue 28,38 . As mentioned previously, some Iranian MMT centers unfortunately provide take-home doses of methadone in unsafe containers, such as mineral water bottles, despite the evidence that opioids are potentially lethal substances and more than 80% of poisonings occur at home accidentally 24,25,30,36,37,40 . Although supervised daily methadone consumption is an established practice in many countries, the US and other countries have recently loosened regulations to allow for take-home doses of methadone of up to 28 days because of COVID-19 guidelines 41 .…”

Section: Discussionmentioning

confidence: 99%

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Fatal Outcome in Acutely Poisoned Children With Hospitalization

et al. 2021

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Background: Acute poisoning is a significant and preventable cause of mortality among children internationally. The aims of this study were to assess the case fatality rate of children admitted to an inner-city hospital for acute poisoning and to compare the demographics and source of poisoning of fatal cases.Methods: This was a retrospective review of patient data recorded in the Hospital Information System for Loghman Hakim Hospital, that is, the central referral hospital for poisoning in Tehran, Iran. We searched Hospital Information System for all admissions for poisoning in children (age, 0--12 years) over the 10-year period from March 2010 to March 2020, and all cases were included in the analysis. We determined the case fatality rate by dividing the number of fatal cases by the number of included cases.Results: Of 8158 children admitted for poisoning, 28 cases (0.3%) died, among whom 19 (67.9%) were boys and 9 (32.1%) girls. The median age was 42 months, ranging from 2 to 144 months. Twenty-two cases (78.6%) were 0 to 5 years old. The most common cause of mortality in acute poisoning was methadone (n = 13, 46.4%), followed by raw opium (n = 5, 17.9%), aluminum phosphide, carbon monoxide, and wild mushrooms (n = 2 deaths each, 7.1%). Tramadol, colchicine, and petroleum accounted for 1 death each (3.6%).Conclusions: Mortality from unintentional poisoning disproportionately affects children younger than 5 years. Opioids (ie, methadone, opium, tramadol) accounted for two thirds of deaths in our sample. Our findings highlight the importance of educating parents that any toxic materials (licit or illicit) must be stored out of reach for children.

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