Predictive indicators for adjustment in 4-year-old children whose mothers used amphetamine during pregnancy

Billing, Lars; Eriksson, Margareta; Steneroth, Gun; Zetterström, Rolf

doi:10.1016/0145-2134(88)90067-1

Cited by 40 publications

(25 citation statements)

References 12 publications

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“…The amphetamine group had more disturbed or problem children if the mother was still addicted. Also at age 4, 58 child adjustment correlated with maternal alcohol and drug use, maternal stress, and paternal criminal convictions. At age 8, 59 the extent of prenatal exposure could be related to psychometric outcome, aggression, peer problems, adjustment, and general assessment, as well as alcohol exposure and pregnancy attitudes.…”

Section: Prenatal Methamphetamine Exposurementioning

confidence: 94%

Children of Addicted Women

Lester

LaGasse

2010

Journal of Addictive Diseases

118

106

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The purpose of this article was to review follow up studies of children with prenatal drug exposure from preschool through adolescence. Specifically, the authors focus on the effects of prenatal exposure to cocaine, methamphetamine, and opiates on behavior and development. The largest number of studies have examined cocaine-exposed children. The authors identified 42 studies that suggest that there are unique effects of prenatal cocaine exposure on 4- to 13-year-old children, particularly in the areas of behavior problems, attention, language, and cognition. In addition, studies make reasonable attempts to control for possible confounding factors. Systematic research on the long-term effects of prenatal methamphetamine exposure is just beginning but seems to be showing similar effects to that of cocaine. The literature on the on the long-term effects of children with prenatal opiate exposure is more substantial than the methamphetamine literature but it is still relatively sparse and surprising in that there is little recent work. Thus, there are no studies on the current concerns with opiates used for prescription mediation. There is a growing literature using neuroimaging techniques to study the effects of prenatal drug exposure that holds promise for understanding brain/behavior relationships. In addition to pharmacological and teratogenic effects, drugs can also be viewed from a prenatal stressor model. The author discuss this “fetal origins” approach that involves fetal programming and the neuroendocrine system and the potential implications for adolescent brain and behavioral development.

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Section: Prenatal Methamphetamine Exposurementioning

confidence: 94%

Children of Addicted Women

Lester

LaGasse

2010

Journal of Addictive Diseases

118

106

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“…At present the only evidence of the long-term effects of prenatal exposure to any ATS come from an early study in Sweden that has followed the growth and development of 65 children exposed prenatally to amphetamine. [3-6,10,21,23-25]. Results using the Terman Merrill method of developmental screening showed the amphetamine exposed children at age four had lower IQ scores (103 vs 110, respectively) and more “problem children” than an unselected community sample of Swedish children.…”

Section: Introductionmentioning

confidence: 99%

Prenatal methamphetamine exposure and neurodevelopmental outcomes in children from 1 to 3years

Wouldes

LaGasse

Huestis

et al. 2014

Neurotoxicology and Teratology

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Background: Despite the evidence that women world-wide are using methamphetamine (MA) during pregnancy little is known about the neurodevelopment of their children. Design: The controlled, prospective longitudinal New Zealand (NZ) Infant Development, Environment and Lifestyle (IDEAL) study was carried out in Auckland, NZ. Participants were 103 children exposed to MA prenatally and 107 not exposed. The Mental Developmental Index (MDI) and the Psychomotor Developmental Index (PDI) of the Bayley Scales of Infant Development, Second Edition (BSID-II) measured cognitive and motor performance at ages 1, 2 and 3, and the Peabody Developmental Motor Scale, Second Edition (PDMS-II) measured gross and fine motor performance at 1 and 3. Measures of the child’s environment included the Home Observation of Measurement of the Environment and the Maternal Lifestyle Interview. The Substance Use Inventory measured maternal drug use. Results: After controlling for other drug use and contextual factors, prenatal MA exposure was associated with poorer motor performance at 1 and 2 years on the BSID-II. No differences were observed for cognitive development (MDI). Relative to non-MA exposed children, longitudinal scores on the PDI and the gross motor scale of the PDMS-2 were 4.3 and 3.2 points lower, respectively. Being male and of Maori descent predicted lower cognitive scores (MDI) and being male predicted lower fine motor scores (PDMS-2) Conclusions: Prenatal exposure to MA was associated with delayed gross motor development over the first 3 years, but not cognitive development. However, being male and of Maori descent were both associated with poorer cognitive outcomes. Males in general did more poorly on tasks related to fine motor development.

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“…Among children exposed to amphetamine continuously throughout pregnancy, emotional characteristics of autism, speech problems and signs of wariness of strangers were noted by age one [5]. By age 4, IQ was lower than a normative group of Swedish children [6] and at age 8 prenatal exposure predicted aggressive behavior and problems with peers [4]. At age 14, the children showed problems with advancement in school due to delays in math and language and had difficulties with physical fitness activities [10].…”

Section: Introductionmentioning

confidence: 99%

Prenatal methamphetamine use and neonatal neurobehavioral outcome

Smith

LaGasse²,

Derauf

et al. 2008

Neurotoxicology and Teratology

164

127

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Background-Methamphetamine (MA) use among pregnant women is an increasing problem in the United States. How prenatal MA exposure affects neonatal neurobehavior is unknown.Objective-To examine the neurobehavioral effects of prenatal MA exposure.Design-The Infant Development, Environment and Lifestyle (IDEAL) study screened 13,808 subjects and 1632 were eligible and consented. 166 (n=74 exposed) were enrolled in a longitudinal follow up. Exposure was determined by meconium assay and self-report with alcohol, marijuana, and tobacco present in both groups. The NICU Network Neurobehavioral Scale (NNNS) was administered within the first 5 days of life. Analyses conducted on NNNS summary scores included exposure group effects, heavy MA use effects, association with frequency of use by trimester, and dose-response relationships with amphetamine metabolites.Results-After adjusting for covariates, exposure to MA was associated with increased physiological stress. Heavy MA use was related to lower arousal, more lethargy, and increased physiological stress. First trimester MA use was related to elevated physiological stress. Third trimester use was related to poorer quality of movement. Higher level of amphetamine metabolites in meconium was associated with increased CNS stress.Conclusions-Prenatal MA exposure was associated with neurobehavioral patterns of decreased arousal, increased stress, and poor quality of movement. The dose response relationships may represent neurotoxic effects from MA.

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Predictive indicators for adjustment in 4-year-old children whose mothers used amphetamine during pregnancy

Cited by 40 publications

References 12 publications

Children of Addicted Women

Children of Addicted Women

Prenatal methamphetamine exposure and neurodevelopmental outcomes in children from 1 to 3years

Prenatal methamphetamine use and neonatal neurobehavioral outcome

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