Predictive markers for response to chemotherapy, organ preservation, and survival in patients with advanced laryngeal carcinoma

Abstract

These predictive markers should be included in future clinical trials of advanced laryngeal cancer to determine their usefulness prospectively.

Reversal of cisplatin resistance with a BH3 mimetic, (−)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL

“…2). These results are consistent with our observations in clinical specimens that p53 overexpression in HNSCC tumors is an independent predictor of successful organ preservation in patients with advanced laryngeal squamous cell carcinoma treated with chemotherapy (cisplatin/5-fluorouracil) followed by radiation (30). This association of wild-type p53 with cisplatin resistance was also shown in a panel of HNSCC cell lines.…”

Predictive biomarkers for combined chemotherapy with 5‑fluorouracil and cisplatin in oro‑ and hypopharyngeal cancers

“…p53 mutations occur in 40-70% of HNSCC patients, leading to extensive research on wild-type p53 as a potential therapeutic target (30). Previous reports have indicated that overexpression of the p53 protein in tumor cells is strongly associated with chemotherapy response and larynx preservation (31,32). High expression of wild-type p53 was also shown to be important for apoptotic cell death in cisplatin-treated cells (33).…”

p53, Apoptosis and Radiosensitivity – Experimental and Clinical Data

“…It appears likely that searching for mutations using sequencing is more reliable than IHC. Newer studies showing more promising results have therefore combined the sequencing for p53 mutations with the determination of additional molecular markers or cell cycle regulatory elements like Bcl-2, T-class antigen or PCNA [72,73] to predict the outcome after tumor therapy in cancer of the head and neck. …”