Predictive medicine: Severe trauma and burns

Babcock, George F.

doi:10.1002/cyto.b.10038

Cited by 15 publications

(13 citation statements)

References 47 publications

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“…In traumatised patients, both cellular and humoral immunity has been reported as being altered. [18] Defects in phagocytosis, bacterial killing, opsonisation and cytokine production have been reported after severe trauma. [19] The depression of innate immune system has been directly correlated with infections in these patients.…”

Section: Pathogenesis Of Infections In Traumatised Patientsmentioning

confidence: 99%

“…[19] The depression of innate immune system has been directly correlated with infections in these patients. [18,20] In patients of trauma, either a hyperactive or suppressed polymorphonuclear (PMN) response may be detected. Hyperresponsive changes can lead to systemic inß ammatory response and multiple organ failure which can lead to death.…”

Section: Pathogenesis Of Infections In Traumatised Patientsmentioning

confidence: 99%

“…Hyporesponsive changes can lead to infections and a variety of associated complications. [18] Studies done to determine the factors which predispose patients to infections after traumatic injury have found that a decrease in the expression of CD 11b, CD 11C, CD 16 and 18 on PMN correlates with systemic infections. [18] These receptors variously regulate the expression of heat shock proteins or are involved in the binding of PMNs.…”

Section: Pathogenesis Of Infections In Traumatised Patientsmentioning

confidence: 99%

“…[18] Studies done to determine the factors which predispose patients to infections after traumatic injury have found that a decrease in the expression of CD 11b, CD 11C, CD 16 and 18 on PMN correlates with systemic infections. [18] These receptors variously regulate the expression of heat shock proteins or are involved in the binding of PMNs. Since the percentage and absolute number of PMN expressing CD 11b and CD 16 correlates with the presence of infections and its response to treatment, it can be used for diagnostic and therapeutic purpose.…”

Section: Pathogenesis Of Infections In Traumatised Patientsmentioning

confidence: 99%

“…[17,21] Due to these immune alterations, immunotherapy in the form of G-CSF along with antibiotics has been shown to be beneÞ cial for traumatised patients in some studies. [18] …”

Section: Pathogenesis Of Infections In Traumatised Patientsmentioning

confidence: 99%

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Infections in traumatised patients: A growing medico-surgical concern

Mathur¹

2008

Indian J Med Microbiol

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Accidents and trauma are a leading global cause of mortality in young adults. Infections are one of the most important causes of death in traumatized patients. This is because of factors related to host and those due to trauma itself. Trauma jeopardizes the host's tissue integrity and immune effector mechanisms. Severely traumatized patients admitted to the ICUs are prone to get nosocomial infections due to open wounds and indwelling life saving devices. Massive blood loss also impairs the distribution of polymorphs, complement and antibiotics to the damaged tissues. Finally, diagnosis of infections in traumatized patients poses a challenge to clinicians due to various factors.

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Section: Pathogenesis Of Infections In Traumatised Patientsmentioning

confidence: 99%

Section: Pathogenesis Of Infections In Traumatised Patientsmentioning

confidence: 99%

Section: Pathogenesis Of Infections In Traumatised Patientsmentioning

confidence: 99%

Section: Pathogenesis Of Infections In Traumatised Patientsmentioning

confidence: 99%

“…[17,21] Due to these immune alterations, immunotherapy in the form of G-CSF along with antibiotics has been shown to be beneÞ cial for traumatised patients in some studies. [18] …”

Section: Pathogenesis Of Infections In Traumatised Patientsmentioning

confidence: 99%

See 3 more Smart Citations

Infections in traumatised patients: A growing medico-surgical concern

Mathur¹

2008

Indian J Med Microbiol

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Mouse Model of Burn Wound and Infection: Thermal (Hot Air) Lesion‐Induced Immunosuppression

2017

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The immunosuppression induced by thermal injury renders the burned victim susceptible to infection. A mouse model was developed to examine the immunosuppression, which was possible to induce even at a minor thermal insult of 6% total body surface area. After induction of the burn (48 hr) a depression of leukocytes in the peripheral blood was found of the burned mice. This depression was due to a reduction in the polymorphonuclear cells. The burned mice were not able to clear a Pseudomonas aeruginosa wound infection, since the infection spread to the blood as compared to mice only infected with P. aeruginosa subcutaneously. The burn model offers an opportunity to study infections under these conditions. The present model can also be used to examine new antibiotics and immune therapy. Our animal model resembling the clinical situation is useful in developing new treatments of burn wound victims. © 2017 by John Wiley & Sons, Inc.

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Systems biology and clinical cytomics: The 10th Leipziger workshop and the 3rd international workshop on slide‐based cytometry

2005

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Despite very significant technical and software improvements in flow cytometry (FCM) since the 1980's, the demand for a cytometric technology combining both quantitative cell analysis and morphological documentation in Cytomics became evident. Improvements in microtechnology and computing permit nowadays similar quantitative and stoichiometric single cell‐based high‐throughput analyses by microscopic instruments, like Slide‐Based Cytometry (SBC). SBC and related techniques offer unique tools to perform complex immunophenotyping, thereby enabling diagnostic procedures during early disease stages. Multicolor or polychromatic analysis of cells by SBC is of special importance not only as a cytomics technology platform but also because of low quantities of required reagents and biological material. The exact knowledge of the location of each cell on the slide permits repetitive restaining and reanalysis of specimens. Various separate measurements of the same specimen can be ultimately fused to one database increasing the information obtained per cell. Relocation and optical evaluation of cells as typical SBC feature, can be of integral importance for cytometric analysis, since artifacts can be excluded and morphology of measured cells can be documented. Progress in cell analytic: In the SBC, new horizons can be opened by the new techniques of structural and functional analysis with the high resolution from intracellular and membrane (confocal microscopy, nanoscopy, total internal fluorescence microscopy (TIRFM), and tissue level (tissomics), to organ and organism level (in vivo cytometry, optical whole body imaging). Predictive medicine aims at the detection of changes in patient's state prior to the manifestation of the disease or the complication. Such instances concern immune consequences of surgeries or noninfectious posttraumatic shock in intensive care patients or the pretherapeutic identification of high risk patients in cancer cytostatic therapy. Preventive anti‐infectious or anti‐shock therapy as well as curative chemotherapy in combination with stem cell transplantation may provide better survival chances for patient at concomitant cost containment. Predictive medicine‐guided optimization of therapy could lead to individualized medicine that gives significant therapeutic effect and may lower or abrogate potential therapeutic side effects. The 10th Leipziger Workshop combined with the 3rd International Workshop on SBC aimed to offer new methods in Image‐ and Slide‐Based Cytometry for solutions in clinical research. It moved towards practical applications in the clinics and the clinical laboratory. This development will be continued in 2006 at the upcoming Leipziger Workshop and the International Workshop on Slide‐Based Cytometry. © 2005 International Society for Analytical Cytology

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Predictive medicine: Severe trauma and burns

Cited by 15 publications

References 47 publications

Infections in traumatised patients: A growing medico-surgical concern

Infections in traumatised patients: A growing medico-surgical concern

Mouse Model of Burn Wound and Infection: Thermal (Hot Air) Lesion‐Induced Immunosuppression

Systems biology and clinical cytomics: The 10th Leipziger workshop and the 3rd international workshop on slide‐based cytometry

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