Predictive Power of Cardiovascular Risk Factors for Detecting Peripheral Vascular Disease

Fine, Jeffrey J.; Hall, Patrick; Richardson, J Huger

doi:10.1097/01.smj.0000141303.47034.46

Southern Medical Journal

2004

DOI: 10.1097/01.smj.0000141303.47034.46

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Predictive Power of Cardiovascular Risk Factors for Detecting Peripheral Vascular Disease

Jeffrey J. Fine¹,

Patrick Hall²,

J Huger Richardson³

Abstract: Our study establishes the following hierarchy of cardiovascular risk factors as predictors of PVD: hypertension, cardiovascular disease, hyperlipidemia, diabetes, tobacco use, obesity, stroke.

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Cited by 6 publications

References 12 publications

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Evidence-based management of peripheral vascular disease

Shammas

Dippel

2005

Curr Atheroscler Rep

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Peripheral vascular disease (PVD) is very prevalent in the United States and is part of a global vascular problem. PVD patients have a heightened inflammatory state and are at high risk of death from acute cardiovascular problems rather than from progression of PVD. Modifiable risk factors for PVD include smoking, hypertension, diabetes, hyperlipidemia, elevated high sensitivity C-reactive protein, obesity, and the metabolic syndrome. Symptomatic treatment of claudication includes smoking cessation, exercise, cilostazol, statins, and revascularization with percutaneous or surgical therapy. Antithrombotic therapy with aspirin or clopidogrel is important to reduce cardiovascular events but does not affect symptoms of claudication. Patients with rest limb ischemia or ulceration should be revascularized to minimize the chance of limb loss. Percutaneous revascularization is not without significant complications, however, and future research needs to focus on inflammation, thrombosis, and restenosis in the PVD patient. Finally, new devices that tackle difficult lesions, drug-eluting stents, and pharmacologic agents that reduce global atherosclerosis are on the horizon and are likely to become critical components in the management of the PVD patient.

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Evidence-based management of peripheral vascular disease

Shammas

Dippel

2005

Curr Atheroscler Rep

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Impact of peripheral arterial disease in patients with diabetes—Results from PROactive (PROactive 11)

Dormandy¹,

Betteridge

Schernthaner

et al. 2009

Atherosclerosis

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A 26-week, prospective, open-label, uncontrolled, multicenter study to evaluate the effect of an escalating-dose regimen of trandolapril on change in blood pressure in treatment-naive and concurrently treated adult hypertensive subjects (TRAIL)

Tytus

Burgess

Assouline

et al. 2007

Clinical Therapeutics

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Predictive Power of Cardiovascular Risk Factors for Detecting Peripheral Vascular Disease

Abstract: Our study establishes the following hierarchy of cardiovascular risk factors as predictors of PVD: hypertension, cardiovascular disease, hyperlipidemia, diabetes, tobacco use, obesity, stroke.

Cited by 6 publications

References 12 publications

Evidence-based management of peripheral vascular disease

Evidence-based management of peripheral vascular disease

Impact of peripheral arterial disease in patients with diabetes—Results from PROactive (PROactive 11)

A 26-week, prospective, open-label, uncontrolled, multicenter study to evaluate the effect of an escalating-dose regimen of trandolapril on change in blood pressure in treatment-naive and concurrently treated adult hypertensive subjects (TRAIL)

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