Predictive risk factors for Listeria monocytogenes meningitis compared to pneumococcal meningitis: a multicenter case–control study

Lim, Seungjin; Chung, Doo Ryeon; Kim, So Hyun; Sohn, Kyung Mok; Kang, Seung-Ji; Jung, Sook-In; Kim, Shin‐Woo; Chang, Hyun Ha; Lee, Seung Soon; Bae, In-Gyu; Moon, Chisook; Rhee, Ji-Young; Lee, Jin Seo; Ki, Hyun Kyun; Kim, Hyun Ah; Ryu, Seong Yeol; Yeom, Joon‐Sup; Son, Jun Seong; Moon, Soo-youn; Kwon, Ki Tae; Lee, Hyuck; Heo, Sang Taek; Kang, Cheol-In; Peck, Kyong Ran; Song, Jae-Hoon

doi:10.1007/s15010-016-0939-2

Cited by 24 publications

(19 citation statements)

References 14 publications

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“…A previous study showed that microglia are relevant target cells for Listeria in the CNS; however, microglia are significant in cerebral listeriosis to avoid pathogen dissemination in the CNS and preserve brain homeostasis (Virna et al, 2006). Moreover, CD8 + T cells are involved in the primary response and are especially important for protective immunity to Listeria infections, and intracellular bacteria-infected cells could be lysed by CD8 + T cells (Lim et al, 2017). Our results expounded that Listeria could directly stimulate microglia to produce MiETs and be entrapped and killed by MiETs without transmission from cell to cell, a phenomenon was confirmed by our results (Figure 1D).…”

Section: Discussionmentioning

confidence: 99%

The TRAPs From Microglial Vesicles Protect Against Listeria Infection in the CNS

Wang

Shi

et al. 2019

Front. Cell. Neurosci.

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Previous studies have demonstrated that T cells and microglia could fight against cerebral Listeria monocytogenes (Listeria); however, their synergistic anti-Listeria mechanisms remain unknown. Following Listeria infection in a culture system, we found that microglia, but not nerve cells, could release extracellular traps (ETs) which originated from microglial vesicles. Specific inhibitor analysis showed that extracellular DNA (eDNA), matrix metallopeptidases (MMP9 and MMP12), citrullinated histone H3, and peptidyl arginine deiminase 2 were the major components of microglial ETs (MiETs) and were also the components of vesicles. Systematic analysis indicated that Listeria-induced MiETs were cytosolic reactive oxygen species (ROS)- and NADPH oxidase (NOX)-dependent and involved ERK. MiETs were exhibited in Listeria-infected mouse brain and might protected against Listeria infection via bacterial killing in a mouse meningitis model, and MiETs existed in cerebrospinal fluid (CSF) from Listeria meningitis patients in vivo and in vitro. A dditionally, interferon-γ could induce MiET formation in Listeria-infected microglia in vitro that was mediated by NOX, and there was a positive relationship between the elevated level of IFN-γ and eDNA and nucleosomes in the brain homogenates and CSF of Listeria meningitis model mice and in the CSF before treatment in clinical Listeria meningitis patients. Together, this is the first report of MiET formation, these findings pave the way for deeper exploration of the innate immune response to pathogens in CNS.

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Section: Discussionmentioning

confidence: 99%

The TRAPs From Microglial Vesicles Protect Against Listeria Infection in the CNS

Wang

Shi

et al. 2019

Front. Cell. Neurosci.

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“…innocua, shared resistance and virulence genes with its infamous close relative L. monocytogenes, is not totally innocuous. As reports have highlighted, L. innocua and L. monocytogenes are commonly detected together in the same ecological niches (Franco et al, 1995;Wagner et al, 2007;Kim et al, 2017;Zhao et al, 2021). This implies the possibility of virulence/resistance gene transferring between these two species on the other side.…”

Section: Discussionmentioning

confidence: 85%

Whole Genome Analysis of Three Multi-Drug Resistant Listeria innocua and Genomic Insights Into Their Relatedness With Resistant Listeria monocytogenes

Yan

Fanning

et al. 2021

Front. Microbiol.

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Listeria innocua are Gram-positive rod-shaped bacteria, which are not generally infectious as opposed to Listeria monocytogenes. However, the comparatively high genomic similarity between both along with on occasion, their coexistence in similar ecological niches may present the opportunity for resistance or virulence gene transfer. In this study, three multi-drug resistant L. innocua originally cultured from food were put forward for long-read genome sequencing. Chromosome and plasmid genomes were assembled and annotated. Analysis demonstrated that the resistant phenotypes correlated well with genotypes. Three plasmids pLI42, pLI203, and pLI47-1 were identified which harbor resistance islands. Sequence alignments suggested that plasmids pLI42 and pLI203 were highly similar to a previously sequenced L. monocytogenes plasmid pLR1. Similarly, another three types of resistance gene islands were observed on chromosome, including tet(M) gene islands (transposon Tn916 orthologs), dfrG gene islands and optrA-erm(A) gene islands. All three L. innocua isolates possessed listeria pathogenicity island-4 (LIPI-4) which is linked to cases of mengitis. Further genome environment and phylogenic analysis of regions flanking LIPI-4 of L. innocua and L. monocytogenes showed that these may have common origins and with the potential to transmit from the former. Our findings raise the possible need to include both L. monocytogenes and L. innocua in food surveillance programs so as to further understand of the origins of antimicrobial resistance and virulence markers of public health importance in L. monocytogenes.

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“…The combination of ampicillin and TMP-SMX has previously been described as an effective treatment for CNS listeriosis [ 21 , 22 ]. A retrospective case-control study indicated that delaying appropriate antibiotic therapy for more than 6 h increased the risk of mortality by 2.78-fold [ 23 ]. Therefore, an early diagnosis is crucial, followed by timely treatment.…”

Section: Discussionmentioning

confidence: 99%

Detection of Listeria monocytogenes in a patient with meningoencephalitis using next-generation sequencing: a case report

Lan

Xiao

Guan³

et al. 2020

BMC Infect Dis

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Background Listeria monocytogenes (L. monocytogenes) is a facultative intracellular bacterial pathogen which can invade different mammalian cells and reach to the central nervous system (CNS), leading to meningoencephalitis and brain abscesses. In the diagnosis of L. monocytogenes meningoencephalitis (LMM), the traditional test often reports negative owing to the antibiotic treatment or a low number of bacteria in the cerebrospinal fluid. To date, timely diagnosis and accurate treatment remains a challenge for patients with listeria infections. Case presentation We present the case of a 66-year-old woman whose clinical manifestations were suspected as tuberculous meningoencephalitis, but the case was finally properly diagnosed as LMM by next-generation sequencing (NGS). The patient was successfully treated using a combined antibacterial therapy, comprising ampicillin and trimethoprim-sulfamethoxazole. Conclusion To improve the sensitivity of LMM diagnosis, we used NGS for the detection of L. monocytogenes. Hence, the clinical utility of this approach can be very helpful since it provides quickly and trust results.

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Predictive risk factors for Listeria monocytogenes meningitis compared to pneumococcal meningitis: a multicenter case–control study

Abstract: Patients with a prior history of receiving immunosuppressive therapy within 1 month and chronic liver disease have 8.1-fold and 5-fold increased risk of meningitis by L. monocytogenes compared to S. pneumoniae, respectively.

Cited by 24 publications

References 14 publications

The TRAPs From Microglial Vesicles Protect Against Listeria Infection in the CNS

The TRAPs From Microglial Vesicles Protect Against Listeria Infection in the CNS

Whole Genome Analysis of Three Multi-Drug Resistant Listeria innocua and Genomic Insights Into Their Relatedness With Resistant Listeria monocytogenes

Detection of Listeria monocytogenes in a patient with meningoencephalitis using next-generation sequencing: a case report

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