Predictive Value of C-Reactive Protein-to-Albumin Ratio for Neonatal Sepsis

Li, Tiewei; Li, Xiaojuan; Wei, Yulei; Dong, Geng; Yang, Jun; Yang, Junmei; Fang, Panpan; Qi, Minglu

doi:10.2147/jir.s321074

Cited by 31 publications

(26 citation statements)

References 43 publications

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“…Emerging studies have revealed that the platelet count is positively related to some chronic inflammatory markers ( 20 , 21 ). In addition to reflecting the nutritional status of the body, ALB is considered to be associated with inflammation ( 22 , 23 ). It is proposed that a new indicator PAR that combines the above two might be able to better reflect the body’s inflammatory state ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Platelet-to-Albumin Ratio: A Novel IgA Nephropathy Prognosis Predictor

et al. 2022

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BackgroundChronic inflammation is related to the development of IgA nephropathy (IgAN). Emerging studies have reported that platelet-related parameters including platelet (PLT), platelet-to-albumin ratio (PAR), and platelet-to-lymphocyte ratio (PLR) are proved to be novel prognostic indicators for several inflammatory diseases. Whether platelet-related parameters could serve as predictors for IgAN remains unknown.MethodsA total of 966 IgAN patients were enrolled in this retrospective study and were divided into several groups based on the optimal cut-off value of the platelet-related parameters. End-stage renal disease was used as the renal endpoint. A 1:2 propensity score (PS) match was then carried out to eliminate significant differences at baseline. The area under the receiver operating characteristic curve (AUROC), Kaplan–Meier (K-M) curve, and Cox proportional hazards analyses were performed to evaluate their predictive effect.ResultsWithout considering the effect of covariates, the K-M curve showed that PLT, PLR, and PAR were strongly correlated with the renal outcomes of IgAN. However, the AUROC revealed that the PAR and PLR had better predictive power than the PLT. Multivariate Cox regression adjusting for demographic data, pathological findings, treatment, and laboratory results indicated that compared with PLR, albumin and PLT, PAR seemed to be a better marker of adverse renal outcome, implying that PAR was the only platelet-related parameter that could be used as an independent risk factor. Notably, high PAR patients seemed to have more severe clinical manifestations and pathological lesions. However, after eliminating the influence of different baselines on outcome variables, the PAR could still predict the poor prognosis of IgAN. To more accurately evaluate the predictive power of the PAR, we analyzed the predictive effect of the PAR on patients with different clinicopathological characteristics through subgroup analysis. It was indicated that the PAR might better predict the prognosis and outcome of patients whose disease was already very severe.ConclusionPAR might be used as an independent risk factor for IgAN progression.

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Section: Discussionmentioning

confidence: 99%

Platelet-to-Albumin Ratio: A Novel IgA Nephropathy Prognosis Predictor

et al. 2022

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“…Studies have revealed that the biomarkers of infection and inflammation play an important role in predicting the presence of sepsis. 26 , 36 , 37 The total and differential leukocyte counts are the less expensive and widely utilised indicators of the inflammatory response. Among leukocytes, neutrophils and lymphocytes are the two most abundant cells in peripheral blood.…”

Section: Discussionmentioning

confidence: 99%

“…The detection methods of these laboratory indices are described in our previous studies. 25 , 26 For our dataset, CRP levels <0.8 mg/L were assigned a value of 0.7 mg/L. PCT level >100 ng/mL or <0.02 ng/mL were assigned, 101 ng/mL and 0.01 ng/mL, respectively.…”

Section: Methodsmentioning

confidence: 99%

Clinical Value of Prognostic Nutritional Index in Prediction of the Presence and Severity of Neonatal Sepsis

Li¹,

Qi²,

Dong³

et al. 2021

JIR

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Purpose The prognostic nutritional index (PNI) is a common indicator of nutritional and inflammatory status and is associated with various diseases such as cancer, cardiovascular diseases and infectious diseases. However, to date, no study has concentrated on the role of PNI in assessing and predicting the presence and severity of neonatal sepsis. Therefore, the present study aimed to explore the association of the PNI with the presence and severity of neonatal sepsis. Materials and Methods A total of 1196 neonates with suspected sepsis were enrolled in this study and their complete clinical and laboratory data were collected. PNI was calculated as serum albumin (g/L) + 5 × total lymphocyte count (10 9 /L). Multivariate logistic regression analysis was performed to identify the risk factors for the presence and severity of neonatal sepsis. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive value of PNI. All statistical analyses were performed using the statistical package SPSS 24.0. Results PNI was lower in neonates with sepsis and decreased significantly with the severity of sepsis. The correlation analysis demonstrated that the PNI was negatively correlated with the levels of the inflammatory marker procalcitonin (PCT) and C-reactive protein (CRP), and the length of hospital stay. Multivariate logistic regression analysis revealed that the PNI was independently and inversely associated with the presence and severity of neonatal sepsis. The area under the ROC curve of the PNI was 0.64 (95% confidence interval (CI): 0.61–0.67, P < 0.001) for severe sepsis and 0.69 (95% CI: 0.60–0.78, P < 0.001) for septic shock. In addition, our data revealed that PNI was also independently correlated with the length of hospital stay. Conclusion PNI is an independent predictor for the presence and severity of neonatal sepsis.

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“…7 Various studies have demonstrated the CRP is an important prognostic factor for neonatal sepsis. [24][25][26][27] However, CRP exhibited a low specificity owing to its physiological increase after birth or the presence of non-infection-related conditions. 11,28 PLTs are anucleate cells that play an important role in modulating haemostasis and developing thrombosis.…”

Section: Discussionmentioning

confidence: 99%

Clinical Value of C-Reactive Protein/Platelet Ratio in Neonatal Sepsis: A Cross-Sectional Study

Li¹,

Li²,

Wang³

et al. 2021

JIR

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Purpose: C-reactive protein (CRP) level and platelet (PLT) count have been demonstrated to be independent risk factor for neonatal sepsis. However, no data is currently available in regarding the association between CRP-to-PLT ratio (CPR) and neonatal sepsis. Methods: A total of 1048 neonates with suspected sepsis were enrolled in this study. Complete clinical and laboratory data were collected. CPR was calculated as CRP (mg/L)/ PLT (10 7 cells/L). Multivariate logistic regression analysis was performed to identify the potential independent risk factors of neonatal sepsis. Receiver operating characteristic (ROC) curve analysis was used to evaluate the prediction accuracy of CPR in predicting neonatal sepsis. Results: Neonates with sepsis had a higher CPR. CPR also showed a gradual increase in the infection, mild sepsis and severe sepsis groups. Multivariate analysis revealed that CPR was a significant independent predictor of the presence of neonatal sepsis (odds ratio [OR], 1.015; 95% confidence interval [CI], 1.008-1.022, P < 0.001) and severe sepsis (OR, 1.002; 95% CI, 1.000-1.003, P = 0.007). ROC curve revealed showed that CPR had a welldiscriminatory power in predicting sepsis (area under curve [AUC], 0.68; 95% CI, 0.65-0.72, P < 0.001) and severe sepsis (AUC, 0.68; 95% CI, 0.65-0.72, P < 0.001). Conclusion:The present study demonstrated that a higher CPR is an independent predictor of the presence and severity of neonatal sepsis.

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Predictive Value of C-Reactive Protein-to-Albumin Ratio for Neonatal Sepsis

Cited by 31 publications

References 43 publications

Platelet-to-Albumin Ratio: A Novel IgA Nephropathy Prognosis Predictor

Platelet-to-Albumin Ratio: A Novel IgA Nephropathy Prognosis Predictor

Clinical Value of Prognostic Nutritional Index in Prediction of the Presence and Severity of Neonatal Sepsis

Clinical Value of C-Reactive Protein/Platelet Ratio in Neonatal Sepsis: A Cross-Sectional Study

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