Predictive value of cathepsin D and Ki-67 expression at the deepest penetration site for lymph node metastases in gastric cancer.

Clinicopathological variables associated with lymph node metastasis in submucosal invasive gastric cancer

“…Because lymph node metastases are present in 10%-25% of patients with submucosal tumors, it is important to assess the presence of lymph node metastasis when we are operating on submucosal gastric cancer and to devise a treatment strategy for nodal metastasis. Many studies have already attempted to defi ne the risk factors for lymph node metastasis of submucosal gastric cancer; these factors include a larger tumor size, deep invasion of the submucosa, tumor ulceration, and lymphatic involvement [1][2][3]. In our study, lymph node metastasis of submucosal gastric cancer was clinicopathologically related to tumor size, the depth of submucosal invasion, lymphatic invasion, and venous invasion.…”

“…For this study, we investigated 38 consecutive patients with lymph node metastasis and 153 patients without lymph node metastasis. We compared the following immunohistochemical features in relation to lymph node metastasis: p53 expression [1], Ki67 expression [2,3], VEGF expression [7,14,15], α-fetoprotein expression [4,5], sLe a expression [6], and DC expression [10][11][12][13][14][15]. Immunohistochemical staining was performed by the streptavidin-biotinperoxidase complex method with a LSAB2 kit (Dako Cytomation, Denmark) and diaminobenzideine (DAB) to visualize the substrate.…”

“…Even in patients with early gastric carcinoma, lymph node metastasis is regarded as having a signifi cant infl uence on the prognosis and the selection of treatment. Several clinicopathological factors, such as the tumor size, tumor stage, lymphatic invasion, and penetrating growth, are known to be correlated with lymph node metastasis [1][2][3].…”

“…Recently, several biological markers have attracted attention because of their correlations with tumor invasion and metastasis [1][2][3][4][5][6][7][8]. Such biological markers may identify tumors with higher invasiveness and more aggressive biological behavior.…”

“…Such biological markers may identify tumors with higher invasiveness and more aggressive biological behavior. There have been many reports about a strong correlation between certain biological markers and the presence of regional lymph node metastasis [1][2][3][4][5][6][7][8].…”