Prognostic use of growth characteristics of early gastric cancer and expression patterns of apoptotic, cell proliferation, and cell adhesion proteins

Pan, Wensheng; Ishii, Hideaki; Ebihara, Yoshiro; Gobé, Glenda C.

doi:10.1002/jso.10204

Cited by 37 publications

(23 citation statements)

References 23 publications

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“…In the current case, immunohistochemical analyses were positive for p53 and Bcl2 protein, which is consistent with other results in the literature 8,9 . Early gastric cancers with low levels of apoptosis, increased Bcl2, and high levels of p53 expression are more likely to invade and metastasize 8 .…”

Section: Why Does the Lesion Fail To Invade The Muscularis Propria Dusupporting

confidence: 93%

Partial Cancerous Changes Eventually Developing into Superficial Spreading Cancer over 18 Months

et al. 2009

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In this report, we describe a patient presenting with the superficial spreading type of early gastric cancer (egc) accompanied by cancerous ulcers. Disease progression and treatment outcome are discussed. After symptoms persisted for more than 1 year, the patient underwent total gastrectomy with D2 lymph node dissection. The patient was diagnosed with superficial spreading cancer (ssc), accompanied by an extensive iic lesions. The progression of this patient suggests that the co-occurrence of cancerous ulcers may contribute to egc development to some extent. As is known, egc often develops into advanced gastric cancer with time. However, in our case, we observed a process during which partial cancerous changes developed into ssc over 18 months. Superficial spreading cancer should be considered an egc variant, which may have the ability to spread superficially along the stomach wall without invading the muscularis propria. But we speculate that, if gene expression changes for some reason, the malignant ssc cells may acquire the ability to grow deeply into the stomach wall. Eventually, Borrmann type iv gastric cancer may develop.

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Section: Why Does the Lesion Fail To Invade The Muscularis Propria Dusupporting

confidence: 93%

Partial Cancerous Changes Eventually Developing into Superficial Spreading Cancer over 18 Months

et al. 2009

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“…Over 50% of patients with gastric cancer operated in China had lymph node metastasis, which resulted in poor prognosis of these patients [10][11][12][13] . As yet, lymph node status has been considered as the major determinant of gastric cancer recurrence for patients undergoing a curative gastrectomy [14][15][16] . However, some authors suggested that the prognostic assessment of these patients by counting the number of positive lymph nodes related to tumor locations was too complicated to be used in routine practice.…”

Section: Discussionmentioning

confidence: 99%

“…However, some authors suggested that the prognostic assessment of these patients by counting the number of positive lymph nodes related to tumor locations was too complicated to be used in routine practice. A simple and easy system for lymph node staging has been considered to be urgently needed [14][15][16] . In the present study, we observed the effect of metastatic lymph node number on the survival years of gastric cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Correlation of tumor-positive ratio and number of perigastric lymph nodes with prognosis of gastric carcinoma in surgically-treated patients

Ding

Chen²,

Xia³

et al. 2004

WJG

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AIM:To evaluate the tumor-positive ratio and number of perigastric lymph nodes as prognostic factors of gastric carcinoma in surgically-treated patients. METHODS:The postoperative survival of 169 patients with gastric cancer who were performed D 2 curative gastrectomy was analyzed with regard to its lymph node metastasis ratio and number. Meanwhile correlation of tumor-positive ratio and number of perigastric lymph nodes with pathological parameters of these patients was studied. RESULTS:The overall 5-year survival rate of all the patients studied was 29.6%. The 5-year cumulative survival rate in patients with 1%-20% and more than 20% of tumor-positive lymph nodes was 70.6% and 12.0% respectively, and 46.6% and 17.4% in those with 1-5 and more than 5 of tumorpositive lymph nodes respectively, which were significantly decreased with the increment of involved lymph nodes assessed by either numbers or ratio (P<0.05). Multiple stepwise regression analysis showed that both the positive ratio and number of tumor-involved lymph nodes were sensitive prognostic factors in these surgically-treated patients, which were also significantly correlated with tumor size and depth of submucosal invasion (P<0.05). CONCLUSION:Tumor-positive ratio and number of perigastric lymph nodes are associated with cancer progression and five-year survival rate, and may serve as valuable prognostic factors of gastric cancer in surgically-treated patients.Ding YB, Chen GY, Xia JG, Zang XW, Yang HY, Yang L,Liu YX. Correlation of tumor-positive ratio and number of perigastric lymph nodes with prognosis of gastric carcinoma in surgicallytreated patients.

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“…Lymph node involvement is the most important indicator of overall survival (OS) of gastric cancer patients following curative resection, and the survival rates markedly decrease in relation to the increase in the number of metastatic-positive nodes (5-10). Furthermore, many investigators have demonstrated that lymph node metastasis is an independent risk factor of gastric cancer recurrence following curative resection (9,11,12). The overall postoperative survival of lymph node-negative gastric cancer patients is significantly longer than that of lymph nodepositive gastric cancer patients.…”

mentioning

confidence: 99%

Prognosis of Gastric Cancer Patients with Node-Negative Metastasis following Curative Resection: Outcomes of the Survival and Recurrence

Deng

Liang

Sun

et al. 2008

Canadian Journal of Gastroenterology

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of gastric cancer patients with node-negative metastasis following curative resection: Outcomes of the survival and recurrence. Can J Gastroenterol 2008;22(10):835-839.BACKGROUND: The purpose of the present study was to provide valuable prognostic information on lymph node-negative gastric cancer patients following curative resection. METHODS: Data from 112 lymph node-negative gastric cancer patients who underwent curative resection were reviewed to identify the independent factors of overall survival and recurrence. RESULTS: The five-year survival rate of lymph node-negative gastric cancer patients was 85.7%, and recurrence was identified in 25 patients after curative surgery. The five-year survival rate of lymph node-negative gastric cancer patients was higher than that of lymph node-positive gastric cancer patients (P<0.001). Recurrence in lymph node-negative gastric cancer patients was less than that of lymph node-positive gastric cancer patients (P=0.001). The median survival after recurrence of lymph node-negative gastric cancer patients was longer than that of lymph node-positive gastric cancer patients (P=0.021). Using multivariate analyses, the following results were determined for lymph node-negative gastric cancer patients: sex, operative type and the presence of serosal involvement were independent factors of overall survival; and lymphadenectomy, number of dissected nodes and the presence of serosal involvement were independent factors of recurrence. CONCLUSIONS: The prognosis of lymph node-negative gastric cancer patients was better than that of lymph node-positive gastric cancer patients. Male sex, subtotal gastrectomy and nonserosal involvement should be considered to be the favourable predictors of postoperative long-term survival of lymph node-negative gastric cancer patients. Conversely, limited lymphadenectomy, few dissected nodes and serosal involvement should be considered to be risk factors of postoperative recurrence of lymph node-negative gastric cancer patients.

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Prognostic use of growth characteristics of early gastric cancer and expression patterns of apoptotic, cell proliferation, and cell adhesion proteins

Abstract: Early gastric cancers with low levels of apoptosis, increased bcl-2, and high levels of p53 expression are more likely to invade and metastasize.

Cited by 37 publications

References 23 publications

Partial Cancerous Changes Eventually Developing into Superficial Spreading Cancer over 18 Months

Partial Cancerous Changes Eventually Developing into Superficial Spreading Cancer over 18 Months

Correlation of tumor-positive ratio and number of perigastric lymph nodes with prognosis of gastric carcinoma in surgically-treated patients

Prognosis of Gastric Cancer Patients with Node-Negative Metastasis following Curative Resection: Outcomes of the Survival and Recurrence

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