Predictive Value of Excision Repair Cross-complementing Rodent Repair Deficiency Complementation Group 1 and Ovarian Cancer Risk

He, Shan; Xu, Lin; Niu, Gang; Ke, Pei Qi; Feng, Miao Miao; Shen, Hong

doi:10.7314/apjcp.2012.13.5.1799

Cited by 9 publications

(6 citation statements)

References 12 publications

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“…Reports in Chinese patients are minimal. A recent hospital-based case-control study did not observe the significant association of rs11615 and rs3212986 with susceptibility to ovarian cancer (He et al, 2012), in line with the result of the present investigation. In contrast, reports in American (Krivak et al, 2008), Canadians (Weberpals et al, 2009)…”

Section: Discussionsupporting

confidence: 91%

Role of common ERCC1 polymorphisms in cisplatin‐resistant epithelial ovarian cancer patients: A study in Chinese cohort

Bao

Yang

Zhao

et al. 2020

Int J Immunogenetics

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Epithelial ovarian cancer (EOC) contributes the majority of death cases among various ovarian malignancies. Although a standard method of treatment is the surgical removal of malignant tissue followed by platinum‐based chemotherapy, a group of patients does not respond appropriately to cisplatin. An appropriate response to cisplatin has been linked with the nucleotide excision repair mechanism. The present study aims to investigate the role of polymorphisms in DNA repair genes, excision repair cross‐complementation group 1 (ERCC1) with susceptibility to EOC development and tumour response to platinum‐based chemotherapy in Chinese EOC patients. Patients (n = 559) reporting to the Department of Oncology and general surgery, the First Affiliated Hospital of Kunming Medical University, were enrolled in the study. Three hundred twenty‐three healthy controls hailing from similar geographical areas without a history of cancer enrolled as healthy controls. Excision repair cross‐complementation group 1 polymorphisms (rs11615, rs3212986, rs735482, rs2336219, rs3212980, rs3212964, rs3212961 and rs2298881) were genotyped by appropriate methods. Distribution of genotypes and allele for ERCC1 polymorphisms (rs11615, rs3212986, rs735482, rs2336219, rs3212980, rs3212964, rs3212961 and rs2298881) were comparable among healthy controls and EOC patients. Interestingly, homozygous mutant and the minor allele for rs11615 and rs3212986 polymorphisms were significantly higher in nonresponder EOC patients when compared to those with a proper response to cisplatin treatment. The prevalence of other SNPs was comparable among the two treated clinical categories. Furthermore, combined genotype revealed significant association of rs11615: TT/ rs3212986: AA genotype combination with cisplatin nonresponder. Variants of rs11615, rs3212986 polymorphisms are associated with cisplatin resistance in Chinese EOC patients. Combined rs11615 and rs3212986 genotypes can be used as a predictive biomarker for platinum‐based chemotherapy outcomes.

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Section: Discussionsupporting

confidence: 91%

Role of common ERCC1 polymorphisms in cisplatin‐resistant epithelial ovarian cancer patients: A study in Chinese cohort

Bao

Yang

Zhao

et al. 2020

Int J Immunogenetics

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“…It is well known that the only established environmental risk factor are ionizing radiation and ultraviolet rays (Sadetzki et al, 2005), these two types of radiation cause an accumulation of DNA damage. XRCC1 and XRCC3 participates in the DNA doublestrand break/recombination repair, previous studies showed these the polymorphisms of XRCC1 and XRCC3 have a role in the risk of various cancers, such as gastric cancer, ovarian cancer, pancreatic cancer, colorectal cancer and lung cancer (McWilliams et al, 2008;He et al, 2012;Liu et al, 2012;Wang et al, 2012;Wen et al, 2012;Zhao et al, 2012). Recently, several studies examined the association between rs1799782 in XRCC1 and rs861539 in XRCC3 and the risk of glioma (Felini et al, 2007;Kiuru et al, 2008;Hu et al, 2011;Zhou et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Study on Associations Between Nine SNPs and Glioma Risk

Liu

Peng²,

Dou³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Aim: Glioma cancer is the most common type of adult brain tumor. Recent genome-wide association studies (GWAS) have identified various new susceptibility regions and here we conducted an extensive analysis of associations between 12 single nucleotide polymorphisms (SNPs) and glioma risk. Methods: A total of 197 glioma cases and 197 health controls were selected, and 9 SNPs in 8 genes were analyzed using the Sequenom MassARRAY platform and Sequenom Assay Design 3.1 software. Results: We found the MAF among selected controls were consistent with the MAF from the NCBI SNP database. Among 9 SNPs in 8 genes, we identified four significant SNP genotypes associated with the risk of glioma, C/C genotype at rs730437 and T/T genotype at rs1468727 in ERGF were protective against glioma, whereas the T/T genotype at rs1799782 in XRCC1 and C/C genotype at rs861539 in XRCC3 conferred elevated risk. Conclusion: Our comprehensive analysis of nine SNPs in eight genes suggests that the rs730437 and rs1468727 in ERGF, rs1799782 in XRCC1 gene, and rs861539 in XRCC3 gene are associated with glioma risk. These findings indicate that genetic variants of various genes play a complex role in the development of glioma.

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“…For example, Jo et al [ 30 ] concluded that no association was found between ERCC1 rs11615 and ovarian cancer risk in Korean women. Moreover, another study investigated the impact of two SNPs in ERCC1 on ovarian cancer susceptibility in Chinese population, and also found that ERCC1 rs3212986 and rs11615 polymorphisms did not show significant association with ovarian cancer risk [ 31 ] The study by Ma et al . [ 32 ] also concluded that there was no relationship between the ERCC1 rs11615 and ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

The association of polymorphisms in nucleotide excision repair genes with ovarian cancer susceptibility

et al. 2018

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Nucleotide excision repair (NER), the core mechanism of DNA repair pathway, was commonly used to maintain genomic stability and prevent tumorigenesis. Previous investigations have demonstrated that single nucleotide polymorphisms (SNPs) of NER pathway genes were associated with various types of cancer. However, there was no research elucidating the genetic association of entire NER pathway with ovarian cancer susceptibility. Therefore, we conducted genotyping for 17 SNPs of six NER core genes (XPA, XPC, XPG, ERCC1, ERCC2, and ERCC4) in 89 ovarian cancer cases and 356 cancer-free controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to describe the strength of association. The result showed that both ERCC1 rs11615 and XPC rs2228000 were significantly associated with reduced risk of ovarian cancer under dominant genetic model (adjusted OR = 0.35, 95% CI = 0.20–0.61, P=0.0002 and adjusted OR = 0.49, 95% CI = 0.30–0.81, P=0.005 respectively). In addition, XPC rs2228001 and ERCC2 rs238406 had statistically significant association with the increased risk of ovarian cancer under dominant genetic model (adjusted OR = 1.72, 95% CI = 1.02–2.92, P=0.043 and adjusted OR = 2.07, 95% CI = 1.07–4.01, P=0.032 respectively). ERCC1 rs3212986 were related with the increased risk of ovarian cancer under recessive model (adjusted OR = 2.40, 95% CI = 1.30–4.44, P=0.005). In conclusion, our results indicated that ERCC1, XPC and ERCC2 might influence ovarian cancer susceptibility. Further research with large sample size is warranted to validate the reliability and accuracy of our results.

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Predictive Value of Excision Repair Cross-complementing Rodent Repair Deficiency Complementation Group 1 and Ovarian Cancer Risk

Cited by 9 publications

References 12 publications

Role of common ERCC1 polymorphisms in cisplatin‐resistant epithelial ovarian cancer patients: A study in Chinese cohort

Role of common ERCC1 polymorphisms in cisplatin‐resistant epithelial ovarian cancer patients: A study in Chinese cohort

Comprehensive Study on Associations Between Nine SNPs and Glioma Risk

The association of polymorphisms in nucleotide excision repair genes with ovarian cancer susceptibility

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