Predictive value of neutrophil to lymphocyte ratio in long‐term outcomes of left main and/or three‐vessel disease in patients with acute myocardial infarction

Xu, Na; Tang, Xiaofang; Yao, Yi; Zhao, Xueyan; Chen, Jue; Gao, Zhan; Yang, Yuejin; Gao, Runlin; Xu, Bo; Yuan, Jinqing

doi:10.1002/ccd.27495

Cited by 41 publications

(31 citation statements)

References 25 publications

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“…In stable coronary artery disease and acute coronary syndrome, NLR is independently associated with mortality 16, 17. A recent study showed that patients with left main disease or triple-vessel disease at NLR ≥ 3.39 have significantly higher incidence of 2-year MACEs, including stroke 21 . Furthermore, a meta-analysis of eight cohort studies demonstrated a higher NLR as a predictor of MACE in patients undergoing coronary angiography or revascularization 22 .…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-lymphocyte ratio predicts heart failure readmissions and outcomes in patients undergoing transcatheter aortic valve replacement

Khalil

Pham

Sawant

et al. 2018

Indian Heart Journal

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ObjectiveNeutrophil-to-lymphocyte ratio (NLR) has prognostic value in acute coronary syndromes. We investigated its utility for predicting heart failure (HF) admissions and major adverse cardiac outcomes in patients undergoing transcatheter aortic valve replacement (TAVR).MethodsData on clinical, laboratory, procedural, HF admissions, and major adverse cardiac events (MACEs) (all-cause mortality, recurrence of myocardial infarction requiring intervention, stroke) for 298 consecutive patients who underwent TAVR between 2012 and 2016 in our tertiary center were collected.ResultsAnalysis included 298 patients. The mean age was 83 ± 8 years, 51% were males, and 95% were Caucasians. The median Society of Thoracic Surgeons risk score was 9 (interquartile range: 6.3–11.8). Receiver-operating curve analysis identified a cutoff value of NLR of 4.0 for MACE after TAVR and sensitivity of 68% and specificity of 68% {area under the curve [AUC] = 0.65 [95% confidence interval (CI): 0.51–0.79], p = 0.03}. An NLR of 4.0 for HF hospitalizations after TAVR and sensitivity of 60% and specificity of 57% [AUC = 0.61 (95% CI: 0.53–0.69), p = 0.01]. NLR ≥4.0 before TAVR significantly predicted MACE after TAVR (68.4% vs. 31.6%, p = 0.02) and HF hospitalizations (58.3% vs. 41.7%, p = 0.03). NLR with TAVR risk score increased the predictive value for MACE after TAVR from AUC = 0.61 (95% CI: 0.50–0.72, p = 0.06) to AUC = 0.69 (95% CI: 0.57–0.80, p = 0.007).ConclusionNLR predicts all-cause mortality, MACE, and HF hospitalization 1 year after TAVR. NLR with TAVR risk score improved predictability for MACE. Further studies for prognostication using NLR are warranted.

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Section: Discussionmentioning

confidence: 99%

Neutrophil-to-lymphocyte ratio predicts heart failure readmissions and outcomes in patients undergoing transcatheter aortic valve replacement

Khalil

Pham

Sawant

et al. 2018

Indian Heart Journal

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“…15–17 Indeed, the NLR and PLR were shown to be significantly altered in diseases including hypertension, chronic heart failure, ischemic stroke, peripheral arterial disease, coronary artery disease, and rheumatoid disease. 7,18,19…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of the blood monocyte–lymphocyte ratio in knee osteoarthritis

Gao

Zhu²,

Liu

et al. 2019

J Int Med Res

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Objective Knee osteoarthritis (KOA) is a chronic inflammatory disease. The monocyte–lymphocyte ratio (MLR) was reported to be a non-invasive, cost-effective marker in various systemic diseases, but it has not yet been investigated in KOA. This cross-sectional study evaluated the diagnostic value of MLR in KOA. Methods Two hundred and five KOA patients and 120 healthy control subjects were enrolled. Patient data, including age, sex, blood cell counts, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels, red blood cell distribution width, and the Kellgren–Lawrence (KL) score were recorded. Results One hundred nineteen patients (55 men, 64 women) were included, with a mean age of 55.47 ± 9.23 years. KOA patients showed a significantly higher MLR, neutrophil–lymphocyte ratio (NLR), and platelet–lymphocyte ratio (PLR) than controls. The MLR area under the curve was 0.81, which was higher than that of NLR and PLR. Multiple logistic regression analysis revealed blood MLR as an independent predictor of KOA. Correlation analysis showed that MLR was positively correlated with ESR and CRP levels. MLR and NLR were significantly higher in KL4 patients than in KL1–3 patients. Conclusions MLR has a high diagnostic value for KOA, so could be a reliable disease marker.

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“…9,10 As the pathophysiology of BP is due to in ammatory mechanism, both Neutrophil to Lymphocyte ratio (NLR) and Platelet to Lymphocyte Ratio (PLR) are high in Bell's palsy patients. 3 Atan et al reported mean NLR and PLR values to be 4.3 and 137.5 respectively in Bell's palsy group which was statistically signi cant when compared to control group. 11 Eryilimaz et al reported mean NLR to be 1.78 (0.93-4.8) among pediatric patients with Bell's palsy which was signi cantly higher when compared to normal pediatric population.…”

Section: Discussionmentioning

confidence: 93%

“…NLR is used to monitor the risk and prognosis patients with cardiovascular disease and cancer. [3][4][5][6] PLR is high in vascular diseases like peripheral and coronary artery diseases and malignancies like gynecological and hepatobiliary cancer. 7 Bell's palsy can lead to signi cant facial asymmetry.…”

Section: Both Neutrophil To Lymphocyte Ratio (Nlr) Andmentioning

confidence: 99%

Predictive Factors of Bell’s Palsy: Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio

Pokharel

Mayya

2020

Preprint

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Objectives: Inflammation plays an important role in the pathogenesis of Bell’s palsy. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are indicators of inflammation. The aim of this study was to find the prevalence of Bell's palsy and the mean of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio among them. Result: Out of all patients who visited ENT outpatient department during the study period, the overall prevalence of Bell’s palsy was 0.6% (117) at a 95% confidence interval (0.5-0.72%). Among them, the mean neutrophil to lymphocyte ratio was 5.014±1.63, and the mean platelet to lymphocyte ratio was 207.38±54.59.Both NLR and PLR values were raised in Bell’s palsy. Therefore, NLR and PLR can be used as auxiliary parameters in the management of Bell’s palsy.

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Predictive value of neutrophil to lymphocyte ratio in long‐term outcomes of left main and/or three‐vessel disease in patients with acute myocardial infarction

Abstract: The admission NLR as relatively inexpensive marker of inflammation may aid in the risk stratification and prognosis of patients diagnosed with LMD/3VD.

Cited by 41 publications

References 25 publications

Neutrophil-to-lymphocyte ratio predicts heart failure readmissions and outcomes in patients undergoing transcatheter aortic valve replacement

Neutrophil-to-lymphocyte ratio predicts heart failure readmissions and outcomes in patients undergoing transcatheter aortic valve replacement

Diagnostic value of the blood monocyte–lymphocyte ratio in knee osteoarthritis

Predictive Factors of Bell’s Palsy: Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio

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