Predictive value of peripheral blood lymphocyte count in breast cancer patients treated with primary chemotherapy

Conesa, M.A. Vicente; García‐Martínez, Elena; Billalabeitia, E. González; Benito, Asunción Chaves; García, Teresa; García, V.; Peña, Francisco Ayala de la

doi:10.1016/j.breast.2011.11.002

Cited by 58 publications

(42 citation statements)

References 40 publications

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“…It has also been reported that low cholesterol level is correlated with poor prognosis in various malignancies as the cholesterol may affect the caloric intake and cell membrane formation 40,41 . What is more, low peripheral lymphocyte count is an indicator for the inadequate host immune response and is correlated to undesirable prognosis in various cancers, including breast cancer 9,42,43 . Thus, the combination of these three parameters could integrate the accuracy of each parameter to assess for the general condition.…”

Section: Discussionmentioning

confidence: 99%

Controlling Nutritional Status (CONUT) score is a prognostic factor in patients with resected breast cancer

Li²,

Wang

et al. 2020

Sci Rep

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CONUT could easily be calculated from blood examination data. Recently, it has been shown that CONUT is an independent prognostic marker in malignant pleural mesothelioma 22 , resected lung squamous cell carcinoma 23 , gastric cancer 4 , and head and neck cancer 24. However, its role in breast cancer has not been reported. To our knowledge, we firstly attempted to assess the prognostic significance of CONUT in breast cancer patients who received curative resection based on a large study. Materials and Methods Patients and follow-up. A total of 1,364 breast cancer patients who received surgical resection from 2007 to 2010 in West China Hospital of Sichuan University were recruited (Supplementary Dataset 1). The complete preoperative blood cell count was procured within seven days before surgery. The exclusion criteria were as follows: (1) patients who received chemotherapy or radiotherapy before the surgery; (2) patients with inflammatory disease or autoimmune disease; (3) patients who lacked detailed clinicopathological information; (4) male breast cancer patients. Finally, 861 cases were included in the present retrospective study. All the patients were followed up every three months in the first three years, every six months for five years, and annually within 6-10 years after the operation. Clinical checkup , laboratory examination and radiological assessment were included in the follow-up investigations.

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Section: Discussionmentioning

confidence: 99%

Controlling Nutritional Status (CONUT) score is a prognostic factor in patients with resected breast cancer

Li²,

Wang

et al. 2020

Sci Rep

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“…It is well established that breast cancer cell metastasis to the axillary lymph node is associated with increased mortality [1, 2]. Notably, the immune status of patients can influence its clinical course [3]. For instance, decreased infiltration of CD8 + cytotoxic T-lymphocytes (CTLs) in tumor has been associated with lymph node metastasis and poor response to neoadjuvant chemotherapy [4–6], while the activation of immune responses has been related to improved overall survival in patients with breast cancer [7].…”

Section: Introductionmentioning

confidence: 99%

The Clinical Significance of CD169-Positive Lymph Node Macrophage in Patients with Breast Cancer

et al. 2016

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The immune status of patients can impact on the clinical course of cancer. Lymph node (LN) macrophages play critical roles in anti-cancer immunity via the activation of cytotoxic T-lymphocytes (CTLs). In this study, the prognostic significance of CD169+ LN macrophages was examined in patients with breast cancer. For this purpose the number of CD169+ cells and their ratio relative to total macrophages (CD68+) in regional LNs (RLNs), as well as the number of CD8+ CTLs in tumor tissues, were investigated using immunohistochemistry of paraffin-embedded tissue samples from 146 patients with breast cancer. The association of these data with clinicopathological factors was then analyzed. The number of cells positive for the pan-macrophage marker CD68 remained relatively uniform, while the number of CD169+ cells varied across all cases. Moreover, a high density of CD169+ cells correlated with early clinical stage and no LN metastasis, while a higher CD169+ to CD68+ ratio was significantly associated with small tumor size and a low Ki-67+ rate. There was also a significant correlation between the number of CD8+ CTLs and that of CD169+ macrophages in high grade breast cancer cases with a Ki-67 index greater than 40%. However, neither the density nor the ratio of CD169+ cells, nor the density of CD8+ CTLs, were associated with relapse-free survival, distant relapse-free survival, or breast cancer-specific survival. These findings suggest that CD169+ macrophages in RLNs might be a useful marker for assessing clinical stage, including LN states, in patients with breast cancer.

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“…Various reports found a relationship between ALC, NLR and PLR and prognosis of breast cancer, most of the studies focusing on LRBP of baseline. [6][7][8][9][10] However, only a few studies focused on the impact of radiotherapy on LRBP in relation to prognosis. And in these research, time points of LRBP were artificial selection, and most of them were before or after radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5] Lymphocyte-related blood parameters (LRBP), including absolute lymphocyte counts (ALC), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), representatives of inflammatory factors, can reflect the immune system status. [6][7][8] Various reports found a relationship between ALC, NLR, and PLR and prognosis of breast cancer. [6][7][8][9][10] Most of the studies focused on baseline LRBP.…”

Section: Introductionmentioning

confidence: 99%

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<p>Predictive Value of Lymphocyte-Related Blood Parameters at the Time Point of Lymphocyte Nadir During Radiotherapy in Breast Cancer</p>

Liu¹,

Ma²,

Sun³

et al. 2020

OTT

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Purpose: Various reports found a relationship between lymphocyte-related blood parameters (LRBP), including absolute lymphocyte counts (ALC), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) and prognosis of breast cancer. Most of the studies focused on LRBP pre-treatment. Seldom have studies focused on LRBP during radiotherapy. We intended to perform a retrospective cohort study on the prognostic value of LRBP at the time point of lowest ALC during radiotherapy for breast cancer. Patients and methods: A total of 158 female patients were included in radiotherapy group because of the strict limitation standards of complete routine blood test results at pretreatment and pre-operation, and at least once a week during radiotherapy. Besides 221 patients, including the 158 patients of radiotherapy group, were adopted in pre-treatment group and pre-operation group. Results: ALC and PLR at the time point of lowest ALC during radiotherapy are prognostic predictors of breast cancer, and lower ALC and higher PLR are independent significant predictors of poor DFS. Besides, lower ALC, higher NLR and higher PLR at both pretreatment and pre-operation were found to be independent variables for predicting poor DFS. Conclusion: LRBP at pre-treatment, pre-operation, and during radiotherapy may serve as predictors of outcomes of breast cancer.

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Predictive value of peripheral blood lymphocyte count in breast cancer patients treated with primary chemotherapy

Cited by 58 publications

References 40 publications

Controlling Nutritional Status (CONUT) score is a prognostic factor in patients with resected breast cancer

Controlling Nutritional Status (CONUT) score is a prognostic factor in patients with resected breast cancer

The Clinical Significance of CD169-Positive Lymph Node Macrophage in Patients with Breast Cancer

<p>Predictive Value of Lymphocyte-Related Blood Parameters at the Time Point of Lymphocyte Nadir During Radiotherapy in Breast Cancer</p>

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