Predictive value of placebo methylphenidate

Children with ADHD and motor dysfunction compared with children with ADHD only

“…Methylphenidate leads to improved motor functioning, specifically fine motor control and writing (Senger and Hallum 1974;Lerer and Lerer 1976;Lerer et al 1977Lerer et al , 1979Tirosh et al 1993, Peeples et al 1995. Anecdotally, some parents did report fewer problems with coordination during medication periods of the trial.…”

The acute effect of methylphenidate in Brazilian male children and adolescents with ADHD: A randomized clinical trial

“…Although significant differences were found between ratings of children's behavior pre-and postmedication, no differences were found between placebo and MPH treatment periods. Tirosh, Elhasid, Kamah, & Cohen (1993) also evaluated the MPH effect in a double-blind, placebo-controlled design in 20 Israeli children with ADHD. They found a significantly higher improvement with MPH through multiple measures.…”

Attention-Deficit Hyperactivity Disorder in Children and Youth: A Quantitative Systematic Review of the Efficacy of Different Management Strategies

“…The majority ofstudies (n = 17) had reasonably good methodological quality (that is, a score of 3 or more) ( Table 1). Twenty-two studies were described as randomized (29-42, 44-46,48-51,26), 22 as double-blind (28)(29)(30)32,33,(35)(36)(37)(38)(39)(41)(42)(43)(45)(46)(47)(48)(49)(50)(51)(52)(53), and 13 provided a statement on withdrawals (31,(35)(36)(37)(40)(41)(42)(44)(45)(46)(49)(50)(51).…”

“…Subjects were diagnosed as having ADD, ADD-H, or ADHD using DSM-III criteria in 14 studies (28)(29)(30)32,33,36,38,41,43,45,47,49,52,53), DSM-III-R criteria in 8 studies (35,37,39,40,46,48,50,51) or a combination ofclinical evaluation and a clinically significant score on a behaviour rating scale in 4 studies (31,34,42,44). Eleven studies reported the presence of a comorbid condition, most frequently conduct disorder Arnold and others (29) Barkley and others (30) Bloomquist and others 31Brown and Sexson 32Brown and others 33Brown and others (34) Buitelaar and others 35Donnelly and others (36) DuPaul and others (37) DuPaul and Rapport (38) Evans and Pelham 39Fehlings and others 40Firestone and others 41Fischer and Newby 42Fitzpatrick and others (43) KJonnan and others (44) McBride and others (45) M usten and others 46Pelham and others 47Rapport and others 48Rapport and others…”