Predictive Value of Platelet-To-Lymphocyte Ratio in Patients with Sarcoidosis

Yalnız, Enver; Karadeniz, Gülistan; Üçsular, Fatma Demirci; Polat, Gülru; Şahin, Görkem Vayısoğlu

doi:10.2217/bmm-2018-0252

Cited by 6 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dirican et al [9] suggested that MPV values were higher in sarcoidosis patients compared to the control group and there was no significant difference in the MPV values of the stages of sarcoidosis.…”

Section: Discussionmentioning

confidence: 97%

“…Mirsaeidi et al [9] reported that the cut-off value was around 3.5 while sensitivity and specificity were 50.0% and 78.0%, respectively. It was concluded in same study that NLR and PLR values of sarcoidosis patients with parenchymal involvement were significantly higher, and cut off values were 2.4 and 158, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Platelet/lymphocyte ratio (PLR) was investigated in sarcoidosis patients, and a significant relationship was detected between the diagnosis of sarcoidosis and lung parenchymal involvement [9].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A novel approach in the diagnosis and follow-up of sarcoidosis

Balcı¹,

Aydın²

2020

Journal of Surgery and Medicine

View full text Add to dashboard Cite

Aim: Sarcoidosis is characterized by the presence of non-caseous granulomas that can involve all organs, especially the lungs and mediastinal lymph nodes. No biomarker investigated in recent years appears to be specific for sarcoidosis. We aimed to investigate and evaluate the relationship between neutrophil-lymphocyte ratios (NLR), platelet-lymphocyte ratios (PLR), monocyte-lymphocyte ratios (MLR), eosinophil-lymphocyte ratios (ELR), and blood count parameters in sarcoidosis patients. Methods: A total of 150 individuals comprising 97 sarcoidosis patients, and 53 controls, were included in the study. The data were recorded retrospectively. Chest X-ray findings were analyzed with regards to age, gender, body mass index, modified medical research concept (MMRC) dyspnea scale and respiratory function parameters. Blood count, NLR, PLR, MLR, eosinophil/basophil ratio (EBR) were evaluated in patients with sarcoidosis. Results: Hemoglobin (g/dl) and lymphocyte count (103 /UL) values were significantly lower in sarcoidosis patients, while red blood cell distribution width standard deviation (RDW SD) (fl), neutrophil count (103 /UL), monocyte count (103 /UL), basophil count (103 /UL), NLR, PLR, MLR values were significantly higher compared to the control group. However, platelet (103 /UL), MPV and EBR values were similar. Conclusion: Our study showed that MLR value, which was not previously used in sarcoidosis patients, is an important biomarker in the diagnosis of sarcoidosis, just as NLR.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A novel approach in the diagnosis and follow-up of sarcoidosis

Balcı¹,

Aydın²

2020

Journal of Surgery and Medicine

View full text Add to dashboard Cite

show abstract

“…9 In a retrospective study on the levels of platelet/lymphocyte ratios of patients with sarcoidosis, it was reported that there was a significant increase in PLR levels in correlation with the involvement of the lung parenchyma in patients with sarcoidosis. 10 It is thought that NLR and PLR studies with hematological parameters will provide a great advantage in the diagnosis of sarcoidosis, which is mainly manifested by lung involvement. In 2020, in a study by Korkmaz et al, it was found that in sarcoidosis patients, PLR and NLR levels were weakly positively correlated with CRP, while there was a moderate positive correlation between NLR levels and blood CD4/CD8 levels.…”

Section: Discussionmentioning

confidence: 99%

“…In various clinical situations, neutrophil/lymphocyte (NLR) and platelet/lymphocyte (PLR) ratios are increased in malignancies, respiratory diseases, cardiovascular diseases, and many inflammatory diseases, and it has been shown that high levels are associated with the poor prognosis and low levels are associated with the good prognosis. 4 Neutrophils play a role in the pathogenesis of many important inflammatory diseases. Neutrophils perform their antimicrobial activities by regulating tissue factor production and thrombocyte activation through oxygen radicals.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of Thrombocyte Aggregates in Sarcoidosis by Flow Cytometric Analysis

2021

JSTR

View full text Add to dashboard Cite

Sarcoidosis is a granulomatous disease characterized by a multisystemic, hyperimmune response that can frequently involve the lung and lymphatic system, but has the potential to involve all organs in the body. A type IV hypersensitivity reaction, in which T cells play a role, is seen with cellular immune response. In addition to clinical and radiological findings, non-caseous granulation seen in biopsy material is used in its diagnosis. In addition, it has been shown that the CD4/CD8 ratio in the bronchoalveolar lavage fluid can be used together with other parameters in the diagnosis of the disease. In this study, it was aimed to evaluate the role of the presence of aggregates in monocyte-neutrophil cell lines in the diagnosis of the disease and the usability of the CD4/CD8 ratio in peripheral blood in patients diagnosed with sarcoidosis. 15 patients with sarcoidosis and 15 healthy individuals were included in the study. Analysis of the samples was carried out in a flow cytometry device (BD, FacsCalibur) using dyes suitable for lymphocyte surface markers CD4-8 and platelet surface markers CD41a-61-14. In the study, no difference was found between CD4/CD8 ratios. In the monocytic series, there was a significant difference between the patient and control groups in terms of CD14-CD61(p<0.001), CD41a(p=0.045) and CD61(p<0.001) values. In addition, a significant difference was found in CD41a (p=0.035) and CD61 (p<0.001) values in neutrophils when comparing patient and control groups (p<0.05). By using the data of the study, further studies are planned that are thought to contribute to the parameters that can be used in the diagnosis of sarcoidosis.

show abstract