Predictive Value of Two Endogenicity Measures

D’Haenen, Hugo; Weert, D De; Feyaerts, Monique

doi:10.1159/000284653

Cited by 3 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yet clinicians are still unable to predict who will respond to a particular antidepressant (1)(2)(3)(4)(5)(6). Yet clinicians are still unable to predict who will respond to a particular antidepressant (1)(2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

“…An immense amount of research effort continues to go into the development of new and better antidepressant medications. Yet clinicians are still unable to predict who will respond to a particular antidepressant (1)(2)(3)(4)(5)(6). A 6-week trial is often recommended before deciding that a patient will not respond to a particular compound (7).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical significance of early non‐response in depressed patients

Boyer

Feighner²

1994

Depression

View full text Add to dashboard Cite

Many authorities recommend a 6-week trial of an antidepressant befire deciding whether the patient will have a favorable response. However, this length of time is fiequently impractical, especially f o r hospitalized patients. Some data suggests that ultimate response to a tricyclic antidepressant may be predicted fiom improvement within the first few weeks. To investigate this issue the authors analyzed data fiom six 6-week double-blind, controlled trials of selective serotonin reuptake inhibitors. Five studies included a placebo control group and all had a n active antidepressant control. Overall the data showed that if there is no improvement early in treatment the chance of meaningfkl response by week 6 is poor. If a patient on active drug does not have at least a 20% improvement in the HAMD score at any point during the first 4 weeks the chance of 6-week response was 3.7%. I f a patient did not have a 20% improvement at 4 weeks but did at one or more previous weeks the chance of 6-week response was 23.1%. The overall response rate f o r the whole sample was 60.7%. Ery similar results were obtained using the Clinical Global Impressions Scale. These data suggest that a f i l l 6-week trial of an antdepressant is usually not warranted i f there is not at least some improvement during the first 4 weeks of the trial. Depression 232-35 (1994). 0 1994 Wiley-Liss, Inc.

show abstract