Predictors of 90-Day Readmission and in-Hospital Mortality in Takotsubo Cardiomyopathy: An Analysis of 28,079 Index Admissions

Yerasi, Charan; Tripathi, Byomesh; Banga, Sandeep; McNown, Camila; Jonnalagadda, Anil Kumar; Al-Qaisi, Saifuldeen; Miryala, Varun; Nafisi, Sina; Waksman, Ron; Ben‐Dor, Itsik

doi:10.1016/j.carrev.2019.08.004

Cited by 22 publications

(32 citation statements)

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“… 4 Another retrospective study showed that DM was an predictor of 90‐day TCM readmission (OR:1.36, 95%CI:1.27–1.47, p < .001). 28 In a prospective study of 826 TCM patients, the mortality was significantly higher in DM‐TCM group than non‐DM‐TCM group (31.4% vs. 16.5%, p < .001) after on average 2.5 years follow up. 21 In the same study, DM was also an independent predictor of adverse outcomes (HR:1.66, 95%CI:1.16–2.39, p = .006).…”

Section: Resultsmentioning

confidence: 95%

“…A 3.8 years follow‐up study showed that DM was an predictor of long‐term mortality (HR:2.11, 95%CI:1.23–3.65, p < .01) 4 . Another retrospective study showed that DM was an predictor of 90‐day TCM readmission (OR:1.36, 95%CI:1.27–1.47, p < .001) 28 . In a prospective study of 826 TCM patients, the mortality was significantly higher in DM‐TCM group than non‐DM‐TCM group (31.4% vs. 16.5%, p < .001) after on average 2.5 years follow up 21 .…”

Section: Resultsmentioning

confidence: 99%

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Conventional cardiovascular risk factors associated with Takotsubo cardiomyopathy: A comprehensive review

Liang

Zhang

et al. 2021

Clinical Cardiology

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Takotsubo cardiomyopathy (TCM), characterized by transient left ventricular dysfunction, was first reported in Japan in 1990. Current research suggests that TCM can be affected by conventional cardiovascular factors such as hypertension (HTN), diabetes, hyperlipidemia (HLD), and obesity. Despite the increasing interest in this disease, research on TCM remains limited. Conventional cardiovascular factors are clinically related to the outcome of TCM. We reviewed the publications published in PubMed database between January 01 2010 and January 15 2021, and summarized the most current available evidence on the correlation between TCM and the conventional cardiovascular factors. TCM patients are predominantly postmenopausal women. Men and young patients are less commonly seen, but are prone to acute adverse complications and poor prognosis. HTN is common in patients with recurrent TCM. Existing evidence suggests that obesity and chronic kidney disease are related to poor prognosis in TCM. HLD is reported to be associated with fewer complications, though current evidence is limited. Finally, the relationship between diabetes and TCM prognosis is ambivalent. Current evidence suggests conventional cardiovascular risk factors are associated with the outcome of TCM, especially with mortality and complications. More prospective studies are needed to clarify the relationship between each risk factor and the prognosis of TCM.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Conventional cardiovascular risk factors associated with Takotsubo cardiomyopathy: A comprehensive review

Liang

Zhang

et al. 2021

Clinical Cardiology

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show abstract

“…20 In patients with TCM, the association between anemia and the in-hospital complications remains unclear; one study reported that anemia had no association with the in-hospital mortality in patients with TCM. 21…”

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confidence: 99%

Anemia Is Associated With Poor Clinical Outcomes in Hospitalized Patients With Takotsubo Cardiomyopathy

Teng

et al. 2021

Angiology

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The association between anemia and Takotsubo cardiomyopathy (TCM) has not been well studied. To assess the effect of anemia on patients hospitalized with TCM, we identified 4733 patients with a primary diagnosis of TCM from the 2016 to 2018 National Inpatient Sample (NIS) database (the United States) using the International Classification of Diseases, 10th edition, Clinical Modification ( ICD-10-CM) code. Of these, 603 (12.7%) patients had a comorbidity of anemia and 4130 did not. After propensity score matching, we compared the in-hospital outcomes between the 2 groups (anemia vs nonanemia, n = 594 vs 1137). Patients with TCM with anemia had significantly higher rates of in-hospital complications, including cardiogenic shock (11.4% vs 4.0%, P < .001), ventricular arrhythmia (6.6% vs 3.6%, P = .008), acute kidney injury (22.7% vs 13.1%, P < .001), acute respiratory failure (22.6% vs 13.1%, P < .001), longer length of hospital stay (5.6 ± 5.8 days vs 3.6 ± 3.6 days, P < .001), and higher total charges (US$79 586 ± 10 2436 vs US$50 711 ± 42 639, P < .001). In conclusion, patients with anemia who were admitted for TCM were associated with a higher incidence of in-hospital complications compared with those without anemia.

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“…Previous data from the US Nationwide Readmission Database showed that patients with TS were likely to exhibit early hospital readmissions, just within the first month after discharge, and causes of readmissions were mostly cardiac, respiratory, and infective complications. 10 However, on multivariate analysis, anemia was one of the significant predictors of readmission, together with age, cancer, and severe chronic comorbidities, such as diabetes, HF, chronic pulmonary disease, and peripheral vascular disease. 10 On the other hand, recent evidence showed that patients with TS had also a poor long-term prognosis, with an overall mortality of 39% within 4 years.…”

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confidence: 99%

“…10 However, on multivariate analysis, anemia was one of the significant predictors of readmission, together with age, cancer, and severe chronic comorbidities, such as diabetes, HF, chronic pulmonary disease, and peripheral vascular disease. 10 On the other hand, recent evidence showed that patients with TS had also a poor long-term prognosis, with an overall mortality of 39% within 4 years. 11 Once again, in multivariate analysis, anemia was a strong predictor for long-term mortality (OR: 3.93, 95% CI: 1.02-2.08, P = .015).…”

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confidence: 99%

Anemia: Another Stone in the Wall of Takotsubo Outcomes?

2021

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Predictors of 90-Day Readmission and in-Hospital Mortality in Takotsubo Cardiomyopathy: An Analysis of 28,079 Index Admissions

Cited by 22 publications

References 21 publications

Conventional cardiovascular risk factors associated with Takotsubo cardiomyopathy: A comprehensive review

Conventional cardiovascular risk factors associated with Takotsubo cardiomyopathy: A comprehensive review

Anemia Is Associated With Poor Clinical Outcomes in Hospitalized Patients With Takotsubo Cardiomyopathy

Anemia: Another Stone in the Wall of Takotsubo Outcomes?

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