Predictors of adverse perinatal outcomes in intrahepatic cholestasis of pregnancy

Abstract

Objectives:Our objective was to evaluate in our clinic the perinatal outcomes of patients diagnosed with ICP based on pre-treatment maternal serum bile acid levels, attempt to identify the risk group and review the literature in light of this information. Material and methods:In total, 370 patients diagnosed with ICP were included in the study, divided into two groups based on the fasting total serum bile acid level before UDCA (Group 1: 10 ≥ 40 μmol/L, and Group 2: ≥ 40 μmol/L). The groups were examined for clinical characteristics and pregnancy outcomes.Results: It was found that preterm delivery and neonatal intensive care need increased at a serum bile acid cut-off value of 34 μmol/L. Regardless of serum bile acid, significantly higher rates of meconium-stained amniotic fluid and foetal distress were observed in patients whose diagnoses were made before 34 weeks of gestation. Conclusions:Foetal complications over 40 μmol/L of serum bile acid were significantly increased. However, slightly lower levels cut-off values (34 μmol/L) were obtained in terms of preterm birth and neonatal intensive care need. The incidence of meconium-stained amniotic fluid and foetal distress was higher in patients whose diagnosis were made before 34 weeks of gestation.

A Study on Intrahepatic Cholestasis in Pregnancy to Evaluate Risk factors for Adverse Perinatal Outcome: An Experience from a Tertiary Care Center of East India

“…Mean age of women was 25.25 ± 3.61 years in the study group. In a similar study, Renu et al [6] and Celik et al [13] described that mean age of 26.42 ± 5.79 years and 27.7 ± 5.3 years was found in their study subjects. Their findings were consistent with the finding found in the present study.…”

The Impact of Assisted Reproductive Technology in Twin Pregnancies Complicated by Intrahepatic Cholestasis of Pregnancy: a Retrospective Cohort Study

“…Although many studies have shown that a high level of serum bile acid causes adverse perinatal outcomes in singleton pregnancies [5][6][7][8][9][10][11], few studies exist on cholestasis in multiple pregnancies. This study aimed to compare the perinatal outcomes of normal twin pregnancies and twin pregnancies involving ICP in a group of 700 participants.…”

Intrahepatic cholestasis of pregnancy: Is fetoplacental doppler ultrasound useful in the diagnosis and follow-up?

“…In spite of the use of biophysical profile and Doppler, babies may die [15]. Premature rates in obstetric cholestasis vary from 19% to 66% [16,17]. In our study, this rate was determined to be 34%.…”