Predictors of anxiety and depression in patients with obstructive sleep apnea

Daabis, Rasha; Gharraf, Heba Said

doi:10.1016/j.ejcdt.2012.10.032

Cited by 13 publications

(7 citation statements)

References 35 publications

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“…Hence to find a correlation between depressiveness and severity of OSAS we may need 66 subjects (r = 0.342, power 80%, α = 0.05). Daabis et al [12] found even greater correlation between depressiveness (HADS-D score) and ESS r = 0.8 (p = 0.002).…”

Section: Conflicts Of Interestmentioning

confidence: 93%

“…Moreover, OSA is currently -regarded as an additional factor contributing to the pathogenesis of obesityrelated comorbidities [8]. Multiple comorbid conditions such as metabolic complications (e.g., obesity, cardiovascular risk factors, ischemic heart disease and atrial fibrillation, impaired lipid levels, insulin resistance or type 2 diabetes mellitus and non-alcoholic fatty liver disease (NAFLD)), insomnia, depression (up to 35% [9]) or accelerated aging are particularly prevalent in individuals with OSA [3,5,[10][11][12][13]. Among OSA patients there are those with extremely high prescription of antidepressants, anxiolytics, hypnotics and sedatives [3].…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, it was established that atypical depression was a risk factor for OSAS in young adults [4]. In particular, patients with OSA and excessive daytime sleepiness (EDS) are more likely to have depressive symptoms as compared to controls [9,11,12,16,17]. Also, the reduced quality of life (QoL) is a strong predictor of psychiatric symptoms in OSAS patients [12].…”

Section: Introductionmentioning

confidence: 99%

“…In particular, patients with OSA and excessive daytime sleepiness (EDS) are more likely to have depressive symptoms as compared to controls [9,11,12,16,17]. Also, the reduced quality of life (QoL) is a strong predictor of psychiatric symptoms in OSAS patients [12]. In contrast, no correlation was observed between the overall severity of OSA and depression scores [9].…”

Section: Introductionmentioning

confidence: 99%

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“Leaky Gut” as a Keystone of the Connection between Depression and Obstructive Sleep Apnea Syndrome? A Rationale and Study Design

et al. 2022

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Obstructive sleep apnea (OSA) and depression are highly comorbid. Immune alterations, oxidative stress or microbiota dysfunction have been proposed as some mechanisms underlying this association. The aim of the proposed study is to assess the severity and profile of OSA and depressive symptoms in the context of serum microbiota metabolites, biomarkers of intestinal permeability, inflammation and oxidative stress in adult patients diagnosed with OSA syndrome. The study population consists of 200 subjects. An apnoea-hypopnoea index ≥ 5/hour is used for the diagnosis. Depressive symptoms are assessed with Beck Depression Inventory. Measured serum markers are: tumour necrosis factor–alpha and interleukin-6 for inflammation, total antioxidant capacity and malondialdehyde concentration for oxidative stress, zonulin, calprotectin, lipopolisaccharide-binding protein and intestinal fatty acids-binding protein for intestinal permeability. All of the above will be measured by enzyme-linked immunosorbent assay (ELISA). Associations between clinical symptoms profile and severity and the above markers levels will be tested. It would be valuable to seek for overlap indicators of depression and OSA to create this endophenotype possible biomarkers and form new prophylactic or therapeutic methods. The results may be useful to establish a subpopulation of patients sensitive to microbiota therapeutic interventions (probiotics, prebiotics, and microbiota transplantation).

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Section: Conflicts Of Interestmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

“Leaky Gut” as a Keystone of the Connection between Depression and Obstructive Sleep Apnea Syndrome? A Rationale and Study Design

et al. 2022

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“…According to Daabis and Gharraf (79), anxiety coexisting with depression in patients with OSAS and no CPAP treatment is associated with the general population, while depressive symptoms are highly prevalent in patients with moderate to severe OSAS and high BMI (80). Moreover, depression relate to functional decrease of serotoninergic neurotransmission, responsible for the alterations in sleep (79). Serotonin delivery to upper airway dilatator motor neurons reduce in dependency of the vigilance state, and lead to reductions in dilator muscle activity specifically during sleep (81).…”

Section: Anxiety and Mood Disordersmentioning

confidence: 99%

Obstructive Sleep Apnea Syndrome: The Effect of Acute and Chronic Responses of Exercise

et al. 2021

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Obstructive Sleep Apnea Syndrome (OSAS) is a sleep disorder with high prevalence in general population, but alarmingly low in clinicians' differential diagnosis. We reviewed the literature on PubMed and Scopus from June 1980–2021 in order to describe the altered systematic pathophysiologic mechanisms in OSAS patients as well as to propose an exercise program for these patients. Exercise prevents a dysregulation of both daytime and nighttime cardiovascular autonomic function, reduces body weight, halts the onset and progress of insulin resistance, while it ameliorates excessive daytime sleepiness, cognitive decline, and mood disturbances, contributing to an overall greater sleep quality and quality of life.

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