Predictors of Clinical Success Among a National Veterans Affairs Cohort With Methicillin-Resistant Staphylococcus aureus Pneumonia

Caffrey, Aisling R.; Morrill, Haley J.; Puzniak, Laura; LaPlante, Kerry L.

doi:10.1016/j.clinthera.2014.02.013

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…Our study did not corroborate any of their findings, specifically, the favorable impact of macrolides, amoxicillin/clavulanate, amoxicillin, or linezolid. 8,13,14 However, we chose to use ICD-9 codes to define a diagnosis of pneumonia, although this is likely an overly broad definition, to capture a "realworld" use of antibiotics. In addition, we included all patients admitted to our hospital with a diagnosis of pneumonia, including patients from nursing facilities and those with recent hospitalizations or antibiotic use.…”

Section: Discussionmentioning

confidence: 99%

Impact of Antibiotic Choice on Pneumonia Readmission Rates

Hemenway

Naretta

2017

American Journal of Therapeutics

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There are many patient and institutional variables associated with a higher risk of rehospitalization within 30 days of an admission for community-acquired pneumonia. However, less is known regarding the impact of antibiotics. A retrospective cohort study of 271 patients was performed to determine whether, when controlling for known factors for readmission, the choice of antibiotic affects 30-day rehospitalization after an index admission of pneumonia. Multivariate logistic regression analysis was performed to determine correlation between antibiotic choice and readmission rates. Empiric tobramycin was associated with a 31.2% increased risk of readmission for any reason (P < 0.01). Empiric and treatment aztreonam were associated with a 13.7% and 13.5% increased risk of readmission with recurrent pneumonia, respectively (both P < 0.05). Further research evaluating these associations is warranted.

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Section: Discussionmentioning

confidence: 99%