Predictors of Coronary Atherosclerosis at Men With the Metabolic Syndrome

Рудакова, Д. М.; Веселовская, Н. Г.; Чумакова, Г. А.; Osipova, Elena S.

doi:10.17802/2306-1278-2017-6-3-84-92

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…(1,2) Lipid abnormality is one of the major risk factors for atherosclerosis. Immune and inflammatory mediators have a complex role in the initiation and progression of atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Markers of Oxidative Stress in Patients with Coronary Heart Disease

Kotova¹,

Зуйкова²,

Пашков³

et al. 2018

IJBM

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The aim of this research was to study the blood levels of protein oxidation products and superoxide dismutase (SOD) activity and their relationship with lipid profile parameters in patients with coronary heart disease (CHD). In CHD patients, against a background of low SOD activity, the protein carbonyl content (PCC) level was significantly higher than in the control group. In addition, significant correlations were found between the indices of PCC, SOD activity, and lipid profile parameters.

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“…(1,2) Lipid abnormality is one of the major risk factors for atherosclerosis. Immune and inflammatory mediators have a complex role in the initiation and progression of atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Markers of Oxidative Stress in Patients with Coronary Heart Disease

Kotova¹,

Зуйкова²,

Пашков³

et al. 2018

IJBM

View full text Add to dashboard Cite

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Diagnostic, prognostic and therapeutic aspects of apelin in cardiovascular diseases

Alieva,

Teplova,

Reznik

et al. 2024

Russian Medicine

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Biological markers have been thoroughly incorporated into clinical practice as a convenient and simple method for diagnosing and monitoring the condition of patients. The analysis of biomarkers has found its niche in oncology; however, their application in cardiovascular diseases is still in its infancy. Studies on apelin indicate the potential diagnostic and prognostic significance of the assessment of this marker in patients with cardiovascular diseases. The beneficial effect of apelin on the heart and blood vessels allows us to consider this marker as a therapeutic target. The combination of apelin with other biological markers, particularly brain natriuretic peptide and its precursor, may increase the predictive value of apelin.

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Role of markers of inflammation and endothelial dysfunction in the prognosis of the development of cardiovascular complications in patients with coronary artery disease and metabolic syndrome after coronary stenting

et al. 2020

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Aim To study the role of inflammation markers and endothelial dysfunction in predicting the risk of cardiovascular event following a percutaneous coronary intervention (PCI) in patients with ischemic heart disease (IHD) and metabolic syndrome (MS).Materials and methods 80 patients (72 men; median age, 56 (50;63) years) with IHD and PCI were evaluated. Based on the presence of MS according to NCEP-ATP III criteria, patients were divided into two groups, group 1 without MS (n=32) and group 2 with MS (n=48). The control age- and sex-matched group included 15 people without cardiovascular diseases. Serum concentrations of tumor necrosis factor α (TNFα), interleukin 6 (IL-6), IL-10, lipoprotein-associated phospholipase A2 (LP-PLA2), and endothelin 1 were measured by enzyme-linked immunosorbent assay (ELISA). Patients were followed up for 12 months after PCI with evaluation of the incidence of adverse cardiovascular events. Statistical analysis was performed with Statistica 10.0 and Medcalc 19.2.6 software. Differences between variables were considered statistically significant at р<0.05. Potential predictors were determined by the ROC analysis with construction of ROC curves, calculation of AUC (area under the curve), identification of COP (cut-off point by the Youden’s index), and sensitivity (Se) and specificity corresponding to the COP.Results Patients with MS had statistically significantly higher serum levels of inflammatory markers than patients of the control group. Concentration of the intravascular inflammation marker, PL-PLA2, was 2.7 times higher in group 1 and 5.1 times higher in group 2 than in the control group (р<0.001). Concentrations of endothelin 1 were 1.9 times higher in group 1 and 3.7 times higher in the MS group compared to the control. At one year after PCI, the incidence of adverse outcomes in the form of cardiovascular events was higher for patients with MS: 10 (20.8 %) cases of stent restenosis and 13 (27.1 %) episodes of coronary atherosclerosis progression according to results of repeated coronarography vs. 2 (6.3%) restenosis cases (χ2–10.853; р=0.002) and 2 (6.3%) episodes of atherosclerosis progression (χ2–23.651; р=0.001) for patients without MS. The groups did not differ in rates of myocardial infarction and cardiac death. The most significant predictors of unfavorable prognosis were LP-PLA2 concentration >983.83 ng/ml (area under the ROC curve, 0.867; sensitivity, 80 %; specificity, 100%; р<0.001) and endothelin 1 overexpression >0.852 fmol/ml (area under the ROC curve, 0.885; sensitivity, 85.5 %; specificity, 83.6 %; р<0.001).Conclusion Patients with MS were characterized by more pronounced imbalance of pro- and anti-inflammatory factors. Concentrations of LP-PLA2 >983.83 ng/ml and endothelin 1 >0.852 fmol/ml were shown to be predictors of unfavorable prognosis for patients with IHD and MS after PCI with coronary stenting.

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Predictors of Coronary Atherosclerosis at Men With the Metabolic Syndrome

Cited by 3 publications

References 11 publications

Markers of Oxidative Stress in Patients with Coronary Heart Disease

Markers of Oxidative Stress in Patients with Coronary Heart Disease

Diagnostic, prognostic and therapeutic aspects of apelin in cardiovascular diseases

Role of markers of inflammation and endothelial dysfunction in the prognosis of the development of cardiovascular complications in patients with coronary artery disease and metabolic syndrome after coronary stenting

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