Predictors of Death and Transplant in Patients With a Mechanical Circulatory Support Device: A Multi-institutional Study

Holman, William L.; Kormos, Robert L.; Naftel, David C.; Miller, Marissa A.; Pagani, Francis D.; Blume, Elizabeth D.; Cleeton, Timothy S.; Koenig, Steven C.; Edwards, Leah B.; Kirklin, James K.

doi:10.1016/j.healun.2008.10.011

Cited by 191 publications

(122 citation statements)

References 22 publications

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“…This result is consistent with findings presented by The Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS), which found that the INTERMACS Level 1 category, characterized by cardiogenic shock with life-threatening hypoperfusion, is one of the risk factors for death after LVAD implantation. 2 In the present series, mean arterial pressure was maintained at 71±16 mmHg and serum lactate level was also stabilized at 1.6±1.1 mmol/L during PCPS (normal <2.0 mmol/L). All but 1 recovered from anuria or oliguria and their urine output was maintained at 662±349 ml for the last 6 h before LVAD implantation, and serum creatine level improved from 3.4±2.0 mg/dl to 1.6±1.3 mg/dl during PCPS (P=0.0173).…”

Section: Discussionsupporting

confidence: 53%

Impact of Preoperative Percutaneous Cardiopulmonary Support on Outcome Following Left Ventricular Assist Device Implantation

Toda

Fujita

Kobayashi

et al. 2012

Circ J

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Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp echanical circulatory support with a left ventricular assist device (LVAD) has become a well-established procedure for patients with end-stage heart failure. Patient selection and timing of implantation, however, remain critical issues. Although several studies have identified pre-implantation risk factors in regard to mortality, 1,2 most are limited by the fact that few of the reported patients were supported by an LVAD for a prolonged period. Because prolonged LVAD support has become prevalent not only as a bridge to transplantation but also for destination therapy, it is important to find preoperative risk factors for patients supported by an LVAD for a prolonged period. Preoperative cardiogenic shock is recognized as one of the significant risk factors for mortality after LVAD implantation, 2,3 and percutaneous cardiopulmonary support (PCPS), has been utilized for patients in cardiogenic shock to improve and stabilize the preoperative condition of LVAD candidates. 4,5 Although those studies demonstrated that PCPS can effectively act as a bridge to LVAD therapy for patients in cardiogenic shock, the duration of LVAD support in previous studies was relatively short, and the impact of preoperative PCPS on long-term LVAD support is not known. In Japan, because of a severe donor shortage, the average LVAD support period before heart transplantation is >2 years, 6 which provides a unique opportunity to observe LVAD patients for prolonged periods. In the present study we retrospectively reviewed 103 consecutive patients to clarify the impact of preoperative PCPS on long-term survival following implantation of an LVAD. Methods PatientsThis study was conducted as a retrospective analysis of 103 consecutive cardiomyopathy patients who underwent LVAD implantation as a bridge to heart transplantation at National Cerebral and Cardiovascular Center, Osaka, between May Background: The purpose of the present study was to determine the impact of preoperative percutaneous cardiopulmonary support (PCPS) on long-term survival following implantation of a left ventricular assist device (LVAD).

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Section: Discussionsupporting

confidence: 53%

Impact of Preoperative Percutaneous Cardiopulmonary Support on Outcome Following Left Ventricular Assist Device Implantation

Toda

Fujita

Kobayashi

et al. 2012

Circ J

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“…Device therapies are not problemfree; postoperative mortality associated with multiple organ failure, stroke, infection, hemorrhage, and even device malfunction remains high. 21,[25][26][27][28] Survival rates for patients who receive VADs as destination therapy are varied and depending on associated risk factors, range between 11% (very high risk) and 81% (low risk). 26,29,30 Examples of commonly used VADs include the HeartMate VE and XVE and HeartMate II.…”

Section: Authorsmentioning

confidence: 99%

Edgar Allan Poe, “The Pit and the Pendulum,” and Ventricular Assist Devices

Zambroski

Combs

Cronin

et al. 2009

Critical Care Nurse

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“…These significant pre-implant variables were selected based on prior studies. [16][17][18] All tests were 2 sided, and P values <0.05 were considered statistically significant. All analyses were performed using SAS version 8.2 (SAS Institute, Cary, NC).…”

Section: Discussionmentioning

confidence: 99%

Regional Differences in Utilization and Outcomes of Left Ventricular Assist Devices: Insights from the INTERMACS Registry

Krim

Vivo

Campbell

et al. 2014

The Journal of Heart and Lung Transplantation

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Predictors of Death and Transplant in Patients With a Mechanical Circulatory Support Device: A Multi-institutional Study

Cited by 191 publications

References 22 publications

Impact of Preoperative Percutaneous Cardiopulmonary Support on Outcome Following Left Ventricular Assist Device Implantation

Impact of Preoperative Percutaneous Cardiopulmonary Support on Outcome Following Left Ventricular Assist Device Implantation

Edgar Allan Poe, “The Pit and the Pendulum,” and Ventricular Assist Devices

Regional Differences in Utilization and Outcomes of Left Ventricular Assist Devices: Insights from the INTERMACS Registry

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