Predictors of Functional and Radiographic Abnormalities 6 Months Post COVID-19 Illness

Klapholz, J.; Heyman, B.; Sunseri, M.; Witzl, A.; Vakil, R.; Young, I.R.; Condos, R.

doi:10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4043

Cited by 1 publication

(5 citation statements)

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“…[12] Persistent inflammatory response is considered to be a key mediator in the formation of long-term sequelae. [8,28] In this study, 44.0% of patients had radiological abnormalities at 2 months, which decreased to 6.5% at 5 months. In a prospective study, the baseline median CT severity score was significantly higher than that at 12 months, supporting radiological improvement.…”

Section: Discussionmentioning

confidence: 47%

“…Another important finding of the current study is that patients with radiological abnormalities at 2 months had significantly lower median FEV1 and FVC levels measured at 5 months. Klapholz et al [8] reported a significant correlation between CT abnormalities and spirometry parameters measured 6 months later. In another study, patients with severe COVID-19 pneumonia had lower lung diffusing capacity for carbon monoxide/alveolar ventilation (DLCO)/VA), total lung capacity (TLC) and FVC at 4 months compared to those with mild pneumonia.…”

Section: Discussionmentioning

confidence: 99%

“…[7] Pulmonary sequelae may permanently affect the physical capacity and functions of individuals later in life; therefore, identifying risk factors that lead to lung injury and taking precautions for these risk factors can contribute to the management of COVID-19-related morbidity and mortality. [2,8,9] Studies dealing with the longitudinal aspect of COVID-19 have mostly investigated dyspnea, radiological findings, pulmonary dysfunction and physical capacity impairment. [5,10,11] Although not enough time has passed to enable conclusions regarding long-term effects, the adverse impacts on the lungs seem to last for months, years, and may perhaps become permanent.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, in other studies including a variety of patients, follow-up periods were often short. [2,5,8] In this study, we aimed to assess the frequency of dyspnea, radiological findings, pulmonary functions and physical capacity change over time among NCPs, and to investigate factors associated with the development of post-COVID-19 radiological abnormalities.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, in other studies including a variety of patients, follow-up periods were often short. [2,5,8]…”

Section: Introductionmentioning

confidence: 99%

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One-year follow-up evaluation of radiological and respiratory findings and functional capacity in COVID-19 survivors without comorbidities

et al. 2023

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The aim of this study was to assess clinical findings, radiological data, pulmonary functions and physical capacity change over time and to investigate factors associated with radiological abnormalities after coronavirus disease 2019 (COVID-19) in non-comorbid patients. This prospective cohort study was conducted between April 2020 and June 2020. A total of 62 symptomatic in non-comorbid patients with COVID-19 pneumonia were included in the study. At baseline and the 2nd, 5th and 12th months, patients were scheduled for follow-up. Males represented 51.6% of the participants and overall mean age was 51.60 ± 12.45 years. The percentage of patients with radiological abnormalities at 2 months was significantly higher than at 5 months (P < .001). At 12 months, dyspnea frequency (P = .008), 6-minute walk test (6MWT) distance (P = .045), BORG-dyspnea (P < .001) and BORG-fatigue (P < .001) scores was significantly lower, while median SpO2 after 6MWT (P < .001) was significantly higher compared to results at 2 months. The presence of radiological abnormalities at 2 months was associated with the following values measured at 5 months: advanced age (P = .006), lung involvement at baseline (P = .046), low forced expiratory volume in 1 second (P = .018) and low forced vital capacity (P = .006). Even in COVID-19 patients without comorbidities, control computed tomography at 2 months and pulmonary rehabilitation may be beneficial, especially in COVID-19 patients with advanced age and greater baseline lung involvement.

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Section: Discussionmentioning

confidence: 47%

Section: Discussionmentioning

confidence: 99%