Predictors of hormonal and metabolic disorders of arterial hypertension and type 2 diabetes mellitus comorbidity

Біловол, Олександр Миколайович

doi:10.20517/2574-1209.2016.11

Cited by 8 publications

(5 citation statements)

References 4 publications

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“…DNA from blood leukocyte samples was isolated using a phenol-chloroform method [13,14,[23][24][25] . DNA amplicons containing the investigated regions of 11 mitochondrial genome mutations (m.12315G>A, m.652delG, m.5178C>A, m.14459G>A, m.3336T>C, 652insG, m.3256C>T, m.1555A>G, m.15059G>A, m.13513G>A, m.14846G>A) were pyrosequenced.…”

Section: Methodsmentioning

confidence: 99%

Mitochondrial mutations associated with cardiac angina

Рыжкова¹,

Sinyov²,

Sazonova³

et al. 2019

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Aim: Cardiac angina is a disease in which discomfort or retrosternal pain may occur. Atherosclerosis of coronary arteries is one of the main risk factors for cardiac angina. The aim of the investigation was to analyze the association of 11 mitochondrial genome mutations with cardiac angina. In our preliminary studies an association of these mutations with atherosclerosis, a risk factor for cardiac angina, was found. Methods: We used samples of white blood cells collected from 192 patients with cardiac angina and 201 conventionally healthy study participants. DNA from blood leukocyte samples was isolated using a phenol-chloroform method. DNA amplicons containing the investigated regions of 11 mitochondrial genome mutations (m.

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Section: Methodsmentioning

confidence: 99%

Mitochondrial mutations associated with cardiac angina

Рыжкова¹,

Sinyov²,

Sazonova³

et al. 2019

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“…Íàéá³ëüøå çíà÷åííÿ ï³äâèùåíîãî àðòåð³àëüíîãî òèñêó ñïîñòåð³ãàºòüñÿ íà ïî÷àòêîâèõ åòàïàõ ðîçâèòêó ÀÑ, îñ-ê³ëüêè çì³íè â äèíàì³ö³ êðîâîòîêó ïðèçâîäÿòü äî ïîøêîäaeåííÿ êëàïàíà íà ñòîðîí³ àîðòè -ä³ëÿíêà, ÿêà ñõèëüíà äî á³ëüø ñèëüíîãî âïëèâó. Ïîÿâà äåôåêò³â åíäîòåë³þ ó öèõ ì³ñöÿõ ïðèçâîäèòü äî ³í³ö³àö³¿ îêñèäàòèâíîãî ñòðåñó òà çàïàëüíèõ ïðîöåñ³â [1]. Â³äîìî, ùî ñòðåñ ìîaeå ïðèçâîäèòè äî òðàíçèòîðíîãî ï³äâèùåííÿ ÀÒ [2,3].…”

Section: âñòóïunclassified

“…The appearance of endothelial defects in these areas leads to the initiation of oxidative stress and inflammatory processes. [1] Bilivol It is known that stress can lead to transient hypertension [4,5]. However, the exact nature of the stimulus, the duration of the stimulus action so that it can lead to serious consequences, the approach used to determine its connection with the increase of blood pressure (BP), or the method of a quantitative assessment of its strength have not been studied sufficiently [9][10][11].…”

Section: Impact Of Vitamin E and Selenium Intake On Antioxidant Prote...mentioning

confidence: 99%

Impact of Vitamin E and Selenium Intake on Antioxidant Protection Indicators During Physical Exertion in Individuals With Hypertension

Dronyk,

Dutka,

Chmyr

et al. 2023

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Hypertension remains one of the main problems in modern medicine since it is a pathogenetic factor leading to a large number of cardiovascular diseases and premature death. The aim of the study is to measure and compare the levels of sulfhydryl groups in plasma and blood as well as reduced glutathione of erythrocytes in patients with stage II hypertension before and after engaging in a controlled physical exercise taking into account the intake of vitamin E and selenium. Material and Methods. There were 60 patients with stage II hypertension and 30 relatively healthy individuals. The individuals under observation performed a two-stage physical exercise on a stationary bicycle ergometer with the intensity, corresponding to 50 and 75% of the maximum oxygen consumption by the body. The overall duration of each stage of the physical exercise accounted for 5 minutes with a three-minute break to rest in between. Blood was taken from the ulnar vein before the cardiac stress test and 5 minutes after it. The content of sulfhydryl groups in plasma and erythrocytes, as well as reduced glutathione of erythrocytes was measured in patients before and after the physical exercise. The examination was conducted twice - before and after the intake of vitamin E and selenium. Results and Discussion. Since the immediate response to a cardiac stress test performed on a stationary bicycle is shown by changes in the level of non-protein-bound sulfhydryl groups of erythrocytes (the level decreases), it can be assumed that they are involved in the formation of the primary compensatory reaction in response to physical exercise in individuals suffering from arterial hypertension. Conclusion. Thus, the decrease in the level of non-protein-bound sulfhydryl groups of erythrocytes enables to assess the degree of stress that affects the human body, as well as the antioxidant protection enhancement in patients with hypertension after taking vitamin E and selenium both before and after engaging in physical exercise.

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“…The problem of atherosclerosis progression in women after menopause has been extensively studied in a number of large-scale clinical studies over the past decades [1][2][3][4][5][6]. In the industrialized countries, atherosclerosis plays a key role in the development of cardiovascular diseases that account for the largest part in the structure of mortality [7].…”

Section: Introductionmentioning

confidence: 99%

Carotid Atherosclerosis Progression in Postmenopausal Women Receiving a Mixed Phytoestrogen Regimen: Plausible Parallels with Kronos Early Estrogen Replacement Study

Kirichenko

Myasoedova

Ravani

et al. 2020

Biology

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This randomized double-blinded, placebo-controlled clinical trial evaluated the progression of intima-media thickness of common carotid artery (cIMT) and the effect of phytoestrogen therapy on atherosclerosis development in early and late postmenopausal women. The 2-year cIMT progression was evaluated in 315 early postmenopausal women aged 40–55 years and in 231 late postmenopausal women aged 60–69 years free of cardiovascular disease. B-mode ultrasound was done at baseline and after 12 and 24 months of follow-up. The study revealed no significant changes in the rate of cIMT progression in 315 early postmenopausal women. By contrast, a statistically significant difference in the rate of atherosclerosis development was observed in late postmenopausal women treated with phytoestrogens compared to placebo (p = 0.008). The rate of cIMT progression in the placebo group was 0.019 mm/year led to a significant increase of cIMT during the observation period (p = 0.012), while the rate of cIMT progression in phytoestrogen late postmenopausal recipients was 0.011 mm/year, and total change did not reach statistical significance during the follow-up period (p = 0.101). These results suggest that late postmenopausal women can be a suitable cohort for trials assessing the anti-atherosclerosis effects of phytoestrogen preparations. In particular, the beneficial effect of phytoestrogens on cIMT progression was demonstrated in late postmenopausal women.

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Predictors of hormonal and metabolic disorders of arterial hypertension and type 2 diabetes mellitus comorbidity

Cited by 8 publications

References 4 publications

Mitochondrial mutations associated with cardiac angina

Mitochondrial mutations associated with cardiac angina

Impact of Vitamin E and Selenium Intake on Antioxidant Protection Indicators During Physical Exertion in Individuals With Hypertension

Carotid Atherosclerosis Progression in Postmenopausal Women Receiving a Mixed Phytoestrogen Regimen: Plausible Parallels with Kronos Early Estrogen Replacement Study

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