Predictors of lung entrapment in malignant pleural effusion

Trovisco, Rita; Freitas, Cláudia; Serino, Mariana; Ferreira, Pestana; Martins, B.; Coelho, D.; Melo, N.; Fernandes, Gabriela; Magalhães, Adriana; Bastos, Hélder Novais

doi:10.1016/j.pulmoe.2022.08.001

Cited by 5 publications

(5 citation statements)

References 25 publications

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“…We found no differences in dyspnoea or symptom burden between patients with and without NEL despite using a comprehensive collection of recognised PROMs concerning malignancy or pleural effusions. The NEL group displayed typical characteristics shown in earlier studies such as lower pleural volume removed [ 32 ], lower symptoms relief with large thoracentesis volumes [ 30 ], and a greater degree of incompletely drained effusions, as well as lower levels of pleural fluid albumin and protein, and elevated lactate dehydrogenase (LDH) [ 32 ]. This would support our NEL cohort being comparable to previous studies [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 98%

“…The NEL group displayed typical characteristics shown in earlier studies such as lower pleural volume removed [ 32 ], lower symptoms relief with large thoracentesis volumes [ 30 ], and a greater degree of incompletely drained effusions, as well as lower levels of pleural fluid albumin and protein, and elevated lactate dehydrogenase (LDH) [ 32 ]. This would support our NEL cohort being comparable to previous studies [ 32 , 33 ]. We expected a higher degree of baseline symptom burden in patients with NEL and MPE, as these patients—in addition to diaphragm immobility induced by pleural effusion—also suffer from impaired lung movement due to NEL [ 34 ].…”

Section: Discussionmentioning

confidence: 98%

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Patient-Reported Outcome Measures in Patients with and without Non-Expandable Lung Secondary to Malignant Pleural Effusion—A Single-Centre Observational Study

Petersen,

Fjaellegaard,

Rasmussen

et al. 2024

Diagnostics

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Background: Malignant pleural effusion (MPE) affects up to 15% of patients with malignancy, and the prevalence is increasing. Non-expandable lung (NEL) complicates MPE in up to 30% of cases. However, it is not known if patients with malignant pleural effusion and NEL are more symptomatic in activities of daily living compared to patients with MPE with expandable lung. Methods: This was an observational study on consecutively recruited patients with MPE from our pleural clinic. Before thoracentesis, patients completed patient-reported outcomes on cancer symptoms (ESAS), health-related quality of life (5Q-5D-5L), and dyspnoea scores. Following thoracentesis, patients scored dyspnoea relief and symptoms during thoracentesis. Data on focused lung ultrasound and pleural effusion biochemistry were collected. The non-expandable lung diagnosis was made by pleural experts based on radiological and clinical information. Results: We recruited 43 patients, including 12 with NEL (28%). The NEL cohort resembled those from previous studies concerning ultrasonography, pleural fluid biochemistry, and fewer cases with high volume thoracentesis. Patients with and without NEL were comparable concerning baseline demography. The 5Q-5D-5L utility scores were 0.836 (0.691–0.906) and 0.806 (0.409–0.866), respectively, for patients with and without NEL. We observed no between-group differences in symptom burden or health-related quality of life. Conclusion: While the presence of NEL affects the clinical management of recurrent MPE, the presence of NEL seems not to affect patients’ overall symptom burden in patients with MPE.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Patient-Reported Outcome Measures in Patients with and without Non-Expandable Lung Secondary to Malignant Pleural Effusion—A Single-Centre Observational Study

Petersen,

Fjaellegaard,

Rasmussen

et al. 2024

Diagnostics

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“…In a study conducted on a group of 365 patients diagnosed with MPE, T rovisco et al . [ 81 ] demonstrate a correlation between the frequency of NEL and lung cancer as the cause of pleural fluid (70.6% of patients with NEL). Furthermore, the occurrence of NEL was higher in patients with identified loculated fluid in the pleural cavity (67% of patients with NEL).…”

Section: Imaging In Prediction Of Pleural Outcomesmentioning

confidence: 99%

Imaging of pleural disease

Hassan,

Touman,

Grabczak

et al. 2024

Breathe

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The pleural space is a “potential” anatomical space which is formed of two layers: visceral and parietal. It normally contains a trace of fluid (∼10 mL in each hemithorax). Diseases of the pleura can manifest with thickening of the pleural membranes or by abnormal accumulation of air or liquid. Chest radiographs are often the first imaging tests to point to a pleural pathology. With the exception of pneumothorax, and due to the inherent limitations of chest radiographs, ultrasound and/or computed tomography are usually required to further characterise the pleural pathology and guide management. This review summarises the utility of different imaging tools in the management of pleural disease and discusses new and evolving tools in imaging of the pleura.

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“… 1 An overall survival of 3 months has recently been reported in patients with MPE, regardless of lung expandability. 3 Indwelling pleural catheters (IPCs) are the primary modality of treatment in MPE patients with nonexpandable lung (NEL) and symptomatic recurrence. Multiple studies have established the effectiveness of IPCs in achieving the palliation of symptoms.…”

Section: To the Editormentioning

confidence: 99%

“…(1) Foi recentemente relatada uma sobrevida global de 3 meses em pacientes com DPM, independentemente da expansibilidade pulmonar. (3) Os cateteres pleurais de longa permanência (CPLP) são a principal modalidade de tratamento em pacientes com DPM que apresentam encarceramento pulmonar e recorrência sintomática. Múltiplos estudos demonstram que os CPLP são eficazes para paliar os sintomas.…”

Section: Ao Editorunclassified

Management and prognosis of malignant pleural effusions managed with indwelling pleural catheters

Martins1,

Serino1,

Viana-Machado1

et al. 2023

J Bras Pneumol.

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Predictors of lung entrapment in malignant pleural effusion

Cited by 5 publications

References 25 publications

Patient-Reported Outcome Measures in Patients with and without Non-Expandable Lung Secondary to Malignant Pleural Effusion—A Single-Centre Observational Study

Patient-Reported Outcome Measures in Patients with and without Non-Expandable Lung Secondary to Malignant Pleural Effusion—A Single-Centre Observational Study

Imaging of pleural disease

Management and prognosis of malignant pleural effusions managed with indwelling pleural catheters

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