Predictors of Malnutrition in Children with Cystic Fibrosis

Dhochak, Nitin; Jat, Kana Ram; Sankar, Jhuma; Lodha, Rakesh; Kabra, Sushil Kumar

doi:10.1007/s13312-019-1607-2

Cited by 10 publications

(9 citation statements)

References 16 publications

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“…For low body weight the authors assumed Wt more than 2 standard deviations below the mean for age (z-score Wt < − 2). The authors also adopted a similar criterion when assessing malnutrition 34 . In the subject literature, short stature is defined as a Ht more than 2 standard deviations below the mean for age (less than the 3rd percentile) 31 , 32 , 35 .…”

Section: Methodsmentioning

confidence: 99%

Microsomic and macrosomic body structure in children and adolescents affected by syndromes or diseases associated with neurodysfunction

Perenc

Guzik

Podgórska‐Bednarz

et al. 2021

Sci Rep

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In Poland the issue of microsomic body structure (micro-SBS) and macrosomic body structure (macro-SBS) has so far been overlooked. Up until now only a small amount of data have been published, most often as an overview of the problem. The current study was designed to investigate the co-occurrence of microsomic/macrosomic body structure (micro/macro-SBS) and congenital nervous system disorders or neurological syndromes with symptoms visible from infancy, based on essential data acquired during admission procedures at a neurological rehabilitation ward for children and adolescents. The study applied a retrospective analysis of data collected during hospitalization of 327 children and adolescents, aged 4–18 years who had been affected since infancy by congenital disorders of the nervous system and/or neurological syndromes associated with a minimum of one neurodysfunction. To identify subjects with microsomic or macrosomic body structure in the group of children and adolescents, the adopted criteria took into account z-score values for body height (z-score Ht), body weight (z-score Wt), head circumference (z-score HC), BMI (z-score BMI) and head circumference index (z-score HCI). The rates of micro/macro-SBS in the study group amounted to 7.3% and 0.6%, respectively. The findings show a more frequent co-occurrence of, as well as statistically significant correlations between, micro/macro-SBS and type of spasticity (cerebral palsy) (p = 0.024) as well as hydrocephalus not treated surgically (p < 0.001). Macro-SBS was found to more frequently co-occur with hemiplegia and hydrocephalus not treated surgically.

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Section: Methodsmentioning

confidence: 99%

Microsomic and macrosomic body structure in children and adolescents affected by syndromes or diseases associated with neurodysfunction

Perenc

Guzik

Podgórska‐Bednarz

et al. 2021

Sci Rep

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“…At diagnosis, 89% of the subjects had moderate to severe malnutrition, similar to data reported from other parts of India. [ 11 ] In contrast, multiple studies from developed countries have proved the positive impact of NBS on short- and long-term nutritional and overall outcomes. [ 13 14 ]…”

Section: Discussionmentioning

confidence: 99%

“…Predictors of malnutrition in Indian children with CF have been described. [ 11 ] However, information on the nutritional recovery of infants from developing countries who are on CF treatment is lacking. The objectives of this study were to describe the early clinical manifestations of CF in infants, assess the response to nutritional therapy, and describe the challenges faced in nutritional management.…”

Section: Introductionmentioning

confidence: 99%

Effect of malnutrition in infants with cystic fibrosis in India

Thomas

John

Lionel

et al. 2021

Journal of Family Medicine and Primary Care

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Aims: To assess the clinical profile and nutritional status of infants with cystic fibrosis (CF) and track their nutritional outcomes with treatment. Materials and Methods: This retrospective study was conducted in a tertiary-care institute in South India. Demographic and clinical information were collected. The nutritional status and treatment outcome was assessed by Z-scores for weight-for-age (WAZ), length-for-age (LAZ), and weight-for-length (WLZ) at diagnosis and follow-up. Results: Nineteen infants with CF had mean follow-up duration of 9.7 ± 8.7 months. There was a mean delay of 2.9 ± 2.1 months from symptom onset to diagnosis, by which time infants were severely malnourished (mean WAZ -4.68 ± 1.8). Pneumonia, summer dehydration with electrolyte abnormalities (42.1%), and a combination of anemia, hypoalbuminemia, and malnutrition (42.1%) were the predominant features. Significant weight loss had been recorded in undiagnosed infants by second month of life before symptom onset. At follow-up, there was a remarkable improvement in WAZ (P 0.001), but not LAZ and WLZ. There was a high mortality rate of 37% in these infants. Conclusions: Malnutrition is a significant morbidity in infants with CF in India. There was significant improvement of WAZ with treatment, but it lagged behind the recommended targets. There is an opportunity for identification of CF infants at the time of vaccination at six and ten weeks of age, by the primary care physician and pediatrician. Screening of young infants having failure to thrive in the immunization clinic may be a strategy for early diagnosis of infants with severe CF phenotype.

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“…Though initial reports demonstrated asymptomatic and mild SARS-CoV-2 infection in children with CF, larger series have described all degrees of severity including intensive care admission especially in post-transplant patients [ 1 – 3 ]. Children with CF from developing countries frequently have advanced lung disease [ 4 ]. The authors’ unit runs a weekly CF clinic with nearly 200 children in regular follow-up cared by clinical specialists, physiotherapist, nutritionist, and specialist nurse.…”

Section: Introductionmentioning

confidence: 99%

Poor Respiratory Health Following Relapsing SARS-CoV-2 Infection in Children with Cystic Fibrosis

et al. 2022

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Children with cystic fibrosis (CF) constitute a high-risk group for COVID-19 with underlying chronic lung disease. COVID-19 severity varying from mild infection to need of intensive care has been described in children with CF. Two children with significant underlying pulmonary morbidity are described here, who developed severe disease following SARS-CoV-2 infection. Case 1 (a 9-y-old boy) had pneumonia with respiratory failure requiring noninvasive ventilation support. He had delayed clearance of SARS-CoV-2, with recurrence of symptomatic disease with short asymptomatic period in between. He was also diagnosed with CF-related diabetes and allergic bronchopulmonary aspergillosis during the second episode. Case 2 (an 18-mo-old boy) had two episodes of SARS-CoV-2–related severe lower respiratory infection within a period of 2 mo, requiring high-flow nasal oxygen support. Both children had 3 rd pulmonary exacerbation but SARS-CoV-2 was not detected in respiratory secretions. To conclude, children with CF with underlying pulmonary morbidity, can develop severe COVID-19 and prolonged SARS-CoV-2 shedding. Supplementary Information The online version contains supplementary material available at 10.1007/s12098-021-04057-0.

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Predictors of Malnutrition in Children with Cystic Fibrosis

Cited by 10 publications

References 16 publications

Microsomic and macrosomic body structure in children and adolescents affected by syndromes or diseases associated with neurodysfunction

Microsomic and macrosomic body structure in children and adolescents affected by syndromes or diseases associated with neurodysfunction

Effect of malnutrition in infants with cystic fibrosis in India

Poor Respiratory Health Following Relapsing SARS-CoV-2 Infection in Children with Cystic Fibrosis

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