Introduction The current study examined whether achieving a sense of meaning in life moderated the association between experienced homophobic stigmatization and coping styles in emerging adult offspring of lesbian mothers. In the sixth wave of the U S National Longitudinal Lesbian Family Study, completed in 2017, the 76 participating offspring were 25 years old. Methods The offspring completed an online survey containing questions about homophobic stigmatization, coping styles (problem-focused, active emotional, and avoidant emotional coping), and meaning in life. Results The interaction between homophobic stigmatization and meaning in life was significant for problem-focused and avoidant emotional coping. Further analyses showed that for participants with low levels of meaning in life, exposure to homophobic stigmatization was associated with less problem-focused coping and more avoidant emotional coping. Discussion The social policy implications of these findings suggest that achieving a sense of meaning in life can serve as a protective factor in reducing the negative influence of homophobic stigmatization on coping styles. Social Policy Implications Thus homophobia associated with being raised by sexual minority parents may affect offspring as adults, even after these offspring no longer live with their parents. This finding illuminates the importance of developing a sense of meaning in life by encouraging self-efficacy on the part of schools and community organizations.