Predictors of mortality and ICU requirement in hospitalized COVID‐19 patients with diabetes: A multicentre study

Asaduzzaman, Md; Bhuia, Mohammad Romel; Bari, Mohammad Zabed Jillul; Alam, Zhm Nazmul; Rahman, Khalidur; Hossain, Enayet; Alam, Munsi Mohammad Jahangir

doi:10.1002/nop2.1567

Cited by 4 publications

References 87 publications

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Hospital admissions for pyoderma gangrenosum in Spain (1999–2021): Epidemiological and clinical characteristics, temporal trends, and factors associated with poor prognosis and higher cost

Belinchón‐Romero,

Sánchez‐Martínez,

Ramos‐Belinchón

et al. 2024

Health Science Reports

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Background and AimsPyoderma gangrenosum (PG) is a neutrophilic inflammatory dermatosis that can be idiopathic or associated with other diseases. The aim was to analyze the epidemiological and clinical characteristics, temporal trends, risk factors for poor prognosis, and admission costs associated with PG in Spain.MethodsWe conducted a retrospective study, based on the Hospital Discharge Registry of the Spanish National Health System in Spain from 1999 to 2021.ResultsOf 82,161,670 admissions during the study period, 4901 were for PG (hospitalization rate of 59.7/1,000,000 admissions). PG hospitalizations increased from 28.8/1,00,000 in 1999 to 91.9/1,000,000 in 2021. PG was a primary cause of admission in 60.5% of cases, and 58.4% of patients were women. The main PG‐related comorbidities were inflammatory bowel disease (15.7%) and neoplasms (10%). There was a significant increase over the years in admissions for inflammatory bowel disease, monoclonal gammopathy of undetermined significance, and lymphoma, as well as an increase in diseases unrelated to PG, such as hypertension, diabetes, and chronic kidney disease. The hospital mortality rate was 5.6%. Death was associated with PG being a primary diagnosis, older age, leukemia, neoplasms, diabetes, and chronic kidney disease. The cost of treatment increased over the years and was higher in older people.ConclusionPG cases in the inpatient setting in Spain over the past 23 years make up a tiny proportion of all hospital admissions, although the rate of hospitalization for PG has increased in the last two decades.

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Hospital admissions for pyoderma gangrenosum in Spain (1999–2021): Epidemiological and clinical characteristics, temporal trends, and factors associated with poor prognosis and higher cost

Belinchón‐Romero,

Sánchez‐Martínez,

Ramos‐Belinchón

et al. 2024

Health Science Reports

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Predictors of mortality and ICU requirement in hospitalized COVID‐19 patients with diabetes: A multicentre study

et al. 2022

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Aim This study aimed to identify the predictors of mortality and ICU requirements in hospitalized COVID‐19 Patients with Diabetes. Design Cross‐sectional study. Methods It was a retrospective study of patients hospitalized with COVID‐19 infection from October 2020–February 2021 in four hospitals in Sylhet, Bangladesh. Logistic regression analysis was applied to explore the predictors of ICU requirement and in‐hospital mortality. Results In the whole cohort (n = 500), 11% of patients died and 24% of patients required intensive care unit (ICU) support. Non‐survivors had significantly higher prevalence of lymphopenia, thrombocytopenia and leukocytosis. Significant predictors of in‐hospital mortality were older age, neutrophil count, platelet count and admission peripheral capillary oxygen saturation (SpO2). Older age, ischemic heart disease, WBC count, D‐dimer and admission SpO2 were identified as significant predictors for ICU requirement. Patient or Public Contribution No.

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The Role of Diabetes on the mortality rate of Patients with COVID-19: A systematic review

Saki,

Nemati,

Ebrahimi

et al. 2023

Preprint

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Background: Type 2 Diabetes Mellitus (T2DM) as a burgeoning health concern in the context of COVID-19 emphasizes the need for solicitous attention and tailored preventive strategies to reduce morbidity and mortality risk. Consistent with this attitude, this systematic review aimed to highlight a wide range of predictive factors that could be related to worse outcomes in COVID-19_DM patients. Methods: The search was done in Pub Med, Web of Sciences, and Science Direct databases using keywords Diabetes, COVID-19, and mortality rates from September 2020 until April 2022 to identify and evaluate the numerous possible prognostic factors that are associated with significant mortality rates in COVID-19_DM patients. Results: Among more than 1200 Studies, 10 articles were considered eligible for more evaluation and were taken forward to the full-text review. Additionally, among more than 25000 COVID-19 patients and more than 6000 COVID-19_DM patients, older age and male gender were the most important mortality-related predictors in COVID-19_DM patients which were pointed out in 5 and 4 studies respectively. It should be noted, that high D-dimer and blood glucose levels could potentiate the risk of death in COVID-19_DM patients. Conclusion: In conclusion and in addition to older age, male gender, high D-dimer, and blood glucose levels, there were several determinant factors like high ferritin, Procalcitonin, A1C (HBA1C), White Blood Cell (WBC), C-Reactive Protein (CRP) level, and also lower Oxygen (O2) saturation and lymphocyte count that are related with the mortality risk in patients. Likewise, pulmonary involvement and some medications like exogenous insulin could result in a debilitating condition in COVID-19_DM patients.

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Predictors of mortality and ICU requirement in hospitalized COVID‐19 patients with diabetes: A multicentre study

Cited by 4 publications

References 87 publications

Hospital admissions for pyoderma gangrenosum in Spain (1999–2021): Epidemiological and clinical characteristics, temporal trends, and factors associated with poor prognosis and higher cost

Hospital admissions for pyoderma gangrenosum in Spain (1999–2021): Epidemiological and clinical characteristics, temporal trends, and factors associated with poor prognosis and higher cost

Predictors of mortality and ICU requirement in hospitalized COVID‐19 patients with diabetes: A multicentre study

The Role of Diabetes on the mortality rate of Patients with COVID-19: A systematic review

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