Predictors of necrotizing enterocolitis in preterm growth-restricted neonates

Manogura, Anita; Turan, Özhan; Kush, Michelle; Berg, Christoph; Bhide, A.; Turan, Şifa; Moyano, Dolores; Bower, Sarah; Nicolaides, Kypros H.; Galan, Henry L.; Müller, Thomas; Thilaganathan, B.; Gembruch, Ulrich; Harman, Christopher; Baschat, Ahmet

doi:10.1016/j.ajog.2007.11.048

Cited by 65 publications

(62 citation statements)

References 26 publications

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“…In presence of severe hypoxia, the diastolic flow reverses and this strongly correlates with gross acidemia and impending neonatal necrotizing enterocolitis due to severe mesenteric ischemia 21 .…”

Section: J Obstet Gynecol India July / August 2010mentioning

confidence: 99%

Colour Doppler in IUGR- Where are we and where do we go?

Lulla

Garg

2010

J Obstet Gynecol India

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Intra-uterine growth restriction (IUGR) is an important perinatal problem giving rise to increased morbidity and mortality in the growth restricted fetus. The aim of fetal medicine today, is to prevent the mere occurrence of IUGR in high risk pregnancies and to deliver the fetuses already afflicted with growth restriction, before they have suffered from the effects of hypoxia. The use of Doppler provides this information, which is not readily obtained from the other conventional tests of fetal well being. The Doppler patterns follow a longitudinal trend in the arterial and venous circulation of the fetus as well as the placental vasculature guiding management decisions regarding the appropriate time of delivery. Progressive knowledge of the fetal circulation and its adaptation when the fetus is subjected to hypoxia, has helped us recognize the early signs of IUGR thereby improving the prognosis of these complicated pregnancies. It has therefore become the gold standard in the management of the growth-restricted fetus.

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Section: J Obstet Gynecol India July / August 2010mentioning

confidence: 99%

Colour Doppler in IUGR- Where are we and where do we go?

Lulla

Garg

2010

J Obstet Gynecol India

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“…Manogura et al reviewed 404 infants affected by growth restriction due to placental disease. 49 Thirty-nine developed NEC, giving an incidence of 9.7% across all gestations; in addition, birth weight ,790 g remained a predominant risk factor for NEC. A recent meta-analysis investigating the outcomes of preterm infants affected by growth restriction compared with those without growth restriction found that the incidence of NEC was at least 2.5 times higher in preterm infants with growth restriction.…”

Section: Intrauterine Growth Restrictionmentioning

confidence: 99%

“…[48][49][50] In a large retrospective analysis, Garite et al reviewed the outcomes of almost 30,000 premature infants born before 34 weeks of gestation. 48 Infants were categorized into three groups: small for gestational age (birth weight below the 10th centile); antenatally diagnosed intrauterine growth restriction (IUGR) and small for gestational age; and antenatally diagnosed IUGR but a birth weight above the 10th centile.…”

Section: Intrauterine Growth Restrictionmentioning

confidence: 99%

Necrotizing enterocolitis: current perspectives

Yajamanyam

Rasiah²,

Ewer³

2014

RRN

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Necrotizing enterocolitis is the most common gastrointestinal emergency in neonates, particularly in those born very preterm. It is a leading cause of morbidity and mortality, especially in extremely low birth weight infants. Despite extensive research, the pathophysiology of necrotizing enterocolitis remains unclear and therapeutic options are limited. Multiple risk factors have been reported, but most are associated with prematurity and its complications. This makes management very challenging in vulnerable preterm infants. In this review, we focus on the risk factors and some of the current research in this area, particularly studies aimed at early detection and potential preventive measures for this potentially lethal condition.

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“…[7][8][9][10] As a consequence of gut ischemia/hypoxia, IUGR infants are thought to have impaired gut function after birth, which may result in intestinal disturbances, ranging from temporary intolerance of enteral feeding to full-blown NEC. 7,8,9,11 Although the exact etiology and pathogenesis of NEC remains elusive, it is well established that NEC is a complex, multi-factorial disease. Besides pre-maturity, research suggests that other potential predisposing factors are hypoxic-ischemic injury, feeding with formula milk and colonization by pathological bacteria.…”

mentioning

confidence: 99%