Predictors of participation in risk-based prostate cancer screening

Koitsalu, Marie; Eklund, Martin; Adolfsson, Jan; Sprangers, Mirjam A. G.; Grönberg, Henrik; Brandberg, Yvonne

doi:10.1371/journal.pone.0200409

Cited by 15 publications

(17 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Low perception of self-vulnerability to PC reported among this at-risk population has been reported in previous studies (16)(17)(18). Perception of self-vulnerability is critical in enhancing the uptake of screening (19). Targeted programs involving clinicians to reach at-risk men to enhance PC awareness and risk perception in the health care facilities and communities are urgently required.…”

Section: Discussionmentioning

confidence: 64%

Barriers and Facilitators to Uptake of Prostate Cancer Screening in a Kenyan Rural Community

Mbugua¹,

Karanja²,

Oluchina³

2021

Ann Afr Surg.

View full text Add to dashboard Cite

Background: Prostate cancer (PC) is curable with early detection, yet it remains a major public health problem globally and a leading cause of mortality among men. The objective of the study was to explore the barriers and facilitators to the uptake of prostate cancer screening among men aged 40–69 years in a rural community in Kenya. Methods: We utilized an explorative qualitative design and purposive sampling to select participants. Six focus group discussions (FGDs) and seven in-depth interviews were conducted among 59 men aged 40–69 years and key informants in Kiambu County, Kenya. Data was collected using a semi-structured guide and content analysis was done. Results: The facilitators of screening included experience of symptoms, proximity and prominence of cancer, accessibility, and advocacy. The barriers to screening included lack of knowledge, fatalistic beliefs, low risk perception, stigma, and male dominance factors. Conclusion: This study provides vital information for the development of interventions to enhance shared decision-making in regard to PC screening. Capacity building of clinicians, task shifting and provision of well-coordinated affordable culturally sensitive screening services should be explored. The concerted effort among policy makers and all health care workers to overcome the stated barriers to screening is highly recommended.

show abstract

Section: Discussionmentioning

confidence: 64%

Barriers and Facilitators to Uptake of Prostate Cancer Screening in a Kenyan Rural Community

Mbugua¹,

Karanja²,

Oluchina³

2021

Ann Afr Surg.

View full text Add to dashboard Cite

show abstract

“…[2,28] Increase in awareness on PC among African men is therefore imperative as it has been associated with participation in PC risk-based screening. [29,30] The study findings indicate the existence of myths and misconceptions which associated PC with sexual behavior. The predominant cause of PC cited during the discussions by the participants was the denial of conjugal rights.…”

Section: Discussionmentioning

confidence: 74%

Prostate cancer awareness and screening among men in a rural community in Kenya: a cross-sectional study

2021

View full text Add to dashboard Cite

Background Globally, prostate cancer ranks as the second most frequently diagnosed cancer among men with the highest mortality rates being in Asia and Africa. The screening rates have been very low among men from developing countries with the majority presenting in advanced stages of the disease. The study aimed to assess the awareness of prostate cancer and screening among men aged 40–69 years in a rural community in Kenya. Methods This cross-sectional mixed-method survey was conducted among men aged 40–69 years. Data were collected using a pretested questionnaire among 576 men and a Focus Group Discussion guide among 44 men. The study was conducted in all the community units in Gatundu North and Kiambu Sub-counties, Kenya. Results Five hundred and seventy-six men participated with a response rate of 100%. Of the men interviewed, 84% had ever heard of prostate cancer. Slightly below half (40.6%) of the respondents had ever heard of prostate cancer screening. There was the existence of myths and misconceptions which predominantly associated prostate cancer with sexual behaviors. Overall, 57.3% of the respondents had a low level of awareness of prostate cancer. The prevalence of prostate cancer screening was 5%. Willingness to undergo screening in the future was high (81%) among the participants. The most frequently cited (56.9%) reason for lack of willingness to screen was the participant’s belief that they were well. Participants who were aware of prostate cancer screening were more likely to take up screening (OR = 8.472; 95% CI: 1.554- 46.186; P = 0.014). Conclusion Awareness of prostate cancer symptoms, treatment, and screening was low with the existence of myths and misconceptions. The level of prostate cancer screening was abysmally low. It is vital for the Ministry of Health, county governments, and other stakeholders to consider the use of multifaceted approaches to increase public awareness on prostate cancer to enhance informed shared decision making. The study provides relevant information for designing prevention and control programs for prostate cancer.

show abstract

“…For each policy 100 million life histories were simulated. We assumed that preferences for PSA testing did not change with the introduction of regular testing, such that only men who would undertake testing under current testing would participate in regular testing [19, 20]. Our modelling of organised screening specifically addresses the effect of screening intensity for the targeted age groups.…”

Section: Resultsmentioning

confidence: 99%

A natural history model for planning prostate cancer testing: Calibration and validation using Swedish registry data

et al. 2019

Self Cite

View full text Add to dashboard Cite

Recent prostate cancer screening trials have given conflicting results and it is unclear how to reduce prostate cancer mortality while minimising overdiagnosis and overtreatment. Prostate cancer testing is a partially observable process, and planning for testing requires either extrapolation from randomised controlled trials or, more flexibly, modelling of the cancer natural history. An existing US prostate cancer natural history model (Gulati et al, Biostatistics 2010;11:707-719) did not model for differences in survival between Gleason 6 and 7 cancers and predicted too few Gleason 7 cancers for contemporary Sweden. We re-implemented and re-calibrated the US model to Sweden. We extended the model to more finely describe the disease states, their time to biopsy-detectable cancer and prostate cancer survival. We first calibrated the model to the incidence rate ratio observed in the European Randomised Study of Screening for Prostate Cancer (ERSPC) together with age-specific cancer staging observed in the Stockholm PSA (prostate-specific antigen) and Biopsy Register; we then calibrated age-specific survival by disease states under contemporary testing and treatment using the Swedish National Prostate Cancer Register. After calibration, we were able to closely match observed prostate cancer incidence trends in Sweden. Assuming that patients detected at an earlier stage by screening receive a commensurate survival improvement, we find that the calibrated model replicates the observed mortality reduction in a simulation of ERSPC. Using the resulting model, we predicted incidence and mortality following the introduction of regular testing. Compared with a model of the current testing pattern, organised 8 yearly testing for men aged 55–69 years was predicted to reduce prostate cancer incidence by 14% and increase prostate cancer mortality by 2%. The model is open source and suitable for planning for effective prostate cancer screening into the future.

show abstract

Predictors of participation in risk-based prostate cancer screening

Cited by 15 publications

References 27 publications

Barriers and Facilitators to Uptake of Prostate Cancer Screening in a Kenyan Rural Community

Barriers and Facilitators to Uptake of Prostate Cancer Screening in a Kenyan Rural Community

Prostate cancer awareness and screening among men in a rural community in Kenya: a cross-sectional study

A natural history model for planning prostate cancer testing: Calibration and validation using Swedish registry data

Contact Info

Product

Resources

About