Predictors of refractoriness in a Turkish status epilepticus data bank

Ağan, Kadriye; Afşar, Nazire; Midi, İpek; Us, Önder; Aktan, Sevinç; Aykut-Bingöl, Canan

doi:10.1016/j.yebeh.2009.02.008

Cited by 39 publications

(48 citation statements)

References 43 publications

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“…Low levels have been identified as predictors of mortality in stroke and coronary heart disease underscoring the impact of inflammation in critically ill patients. Characteristics in both cohorts were similar to prior studies regarding RSE risk factors with the exception of a slightly higher proportion with treatment refractoriness, 45%–46.6% vs. 20%–43% in prior studies . Median age in both cohorts was similar to prior SE studies and short‐term mortality was similar to population‐based and single‐center SE studies .…”

Section: Discussionsupporting

confidence: 74%

Early predictors of refractory status epilepticus: an international two‐center study

Sutter

Kaplan

Marsch

et al. 2014

Euro J of Neurology

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Section: Discussionsupporting

confidence: 74%

Early predictors of refractory status epilepticus: an international two‐center study

Sutter

Kaplan

Marsch

et al. 2014

Euro J of Neurology

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“…Whether age contributes to the progression of RSE/SRSE is still controversial. Some scholars proposed age as a high risk factor of RSE [19, 20], while others did not find an association between age and occurrence of RSE [12]. In our study, we noted a significant difference in the average age of the 2 groups, strongly suggesting that age is an independent risk factor for RSE.…”

Section: Discussioncontrasting

confidence: 47%

The Clinical Characteristics and Prognostic Analysis of Status Epilepticus in Northeast China

2017

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Objective: Status epilepticus (SE) is a neurological emergency that may cause severe neurological deficiency and even death. The aim of this study was to analyze the clinical characteristics and prognosis of SE in northeast China. Additionally, the etiology and classification are discussed. Materials and Methods: We retrospectively collected the clinical profiles of patients diagnosed with SE in the Epilepsy Center of Jilin University between January 2011 and May 2015. The causes and clinical courses were investigated. The individuals were followed up by visit or telephone, and the prognoses were analyzed. Results: A total of 223 patients with SE were enrolled, including 134 cases with non-refractory SE (NRSE) and 89 cases with refractory or super-refractory SE (RSE/SRSE). Fifteen patients died during hospitalization, yielding a mortality of 6.73%; 11 of them succumbed to multiple organ dysfunction syndrome (MODS). Statistical analysis showed significant differences in age, family history of epilepsy, and the incidence of non-convulsive SE (NCSE) between the NRSE group and RSE/SRSE group (p < 0.05). We found no significant differences in the causes of SE (central nervous system infection, autoimmune encephalitis, and epilepsy) between these 2 groups. Conclusion: In northeast China, SE is associated with relatively lower mortality, and MODS is the major cause of death. Older age and NCSE are risk factors predicting potential progression to RSE. Central nervous system infection, autoimmune encephalitis, and epilepsy were common causes of SE, but there was no significant association between any of these causes and the occurrence of RSE.

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“…This comment should be interpreted very cautiously because worsening of the ongoing sepsis or additional problems due to IVAD could not be excluded. It is debatable whether NCSE is directly associated with higher mortality rates or poor cognitive and neurologic outcomes, although it is known that NCSE is associated with refractoriness(Agan et al, 2009; Mayer et al, 2002). Nevertheless, there is a need to address this ongoing debate with further studies that isolate the effectiveness of IVAD in refractory NCSE(Fountain and Fugate, 2014; Sutter and Kaplan, 2015).…”

Section: Discussionmentioning

confidence: 99%

Intravenous anesthesia in treatment of nonconvulsive status epilepticus: Characteristics and outcomes

et al. 2015

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Objective To determine factors associated with continuous anesthetic drug (IVAD) use in nonconvulsive status epilepticus (NCSE). Methods Retrospective cohort study of patients who met clinical and EEG criteria of NCSE from 2009 to 2014 at a tertiary academic medical center. Patients were categorized according to IVAD use. Outcome variables were response to treatment and in-hospital death. We used descriptive analyses for baseline characteristics and outcome variable differences among patients who did and did not receive IVAD. Results Forty-three patients had a total of 45 NCSE episodes. IVAD was used in 69% of the episodes. Patients treated with IVAD were younger (53.1±14.1 vs 64.1±13.3, p=0.019). The episodes treated with IVAD occurred more frequently in patients with an acute neurologic pathology (58% vs 21%, p=0.024) and those presenting in a coma (39% vs 7%, p=0.030). NCSE resolved in 74% of the patients who received IVAD. Duration of NCSE did not differ significantly by treatment group. There were total 13 in-hospital deaths: ten in IVAD users vs three in the no-IVAD group (p > 0.05). Only one in-hospital death appeared to be a direct consequence of IVAD use. Mortality was more common among episodes that were not treated according to the published status epilepticus treatment guidelines compared to the episodes where guidelines were followed. Conclusion Our findings showed that factors such as younger age, acute neurologic pathology and coma at presentation were associated with IVAD use in patients with NCSE. These factors should be controlled in the future outcome and effectiveness studies to determine the effect of IVAD use on outcome of NCSE.

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Predictors of refractoriness in a Turkish status epilepticus data bank

Cited by 39 publications

References 43 publications

Early predictors of refractory status epilepticus: an international two‐center study

Early predictors of refractory status epilepticus: an international two‐center study

The Clinical Characteristics and Prognostic Analysis of Status Epilepticus in Northeast China

Intravenous anesthesia in treatment of nonconvulsive status epilepticus: Characteristics and outcomes

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